Asian Journal of Research in Chemistry

ISSN

0974-4150 (Online)
0974-4169 (Print)


Submit Article

Structural and Biological Activity Studies on Metal Complexes Containing Thiosemicarbzone and Isatin Based Schiff Base: A Review

Author(s): Saddam Hossain, C. M. Zakaria, Kudrat-E-Zahan

Email(s): kudrat.chem@ru.ac.bd

DOI: 10.5958/0974-4150.2017.00002.5   

Address: Md. Saddam Hossain, C. M. Zakaria, Md. Kudrat-E-Zahan*
Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh.
*Corresponding Author

Published In:   Volume - 10,      Issue - 1,     Year - 2017

 View HTML        View PDF

ABSTRACT:
Thiosemicarbazones are Schiff base ligands which have achieved much attention by the scientist over the decades as potential drug agent. Isatin is an endogenous compound isolated in 1988 and reported to possess a wide range of structural and biological activities involving the central nervous system. The versatility and flexibility of Schiff base compounds having, acyl, aroyl and heteroacroyl ligands have additional donor sites >C=O, >C=N-, >C=S etc. have made the Schiff bases to act as good complexing agents that form a variety of complexes with various transition and inner transition metals which also emphasized the attention of many researchers. Azomethine linkage(-CH=N-) of Schiff base play an significant role in medical field with so many pharmacological applications such as antimicrobial, antiviral, anti-tubercularculosis, anti-HIV, anti-diuretic and anticancer activity. The potency of these pharmaceutically useful drugs in treatment of microbial infections and other activities inspired the scientist for the development of some more potent and significant compounds and metal complexes over the years. Schiff base ligands are considered privileged ligands because they are easily prepared by a simple condensation reaction of an aldehyde and primary amines. In this review, the synthesis, biological activities along with application of Schiff base derived from isatin and thiosemicarbazides and their metal complexes are summarized.


Keywords:

Cite this article:
Saddam Hossain, C. M. Zakaria, Kudrat-E-Zahan. Structural and Biological Activity Studies on Metal Complexes Containing Thiosemicarbzone and Isatin Based Schiff Base: A Review. Asian J. Research Chem. 2017; 10(1):6-13. doi: 10.5958/0974-4150.2017.00002.5

Cite(Electronic):
Saddam Hossain, C. M. Zakaria, Kudrat-E-Zahan. Structural and Biological Activity Studies on Metal Complexes Containing Thiosemicarbzone and Isatin Based Schiff Base: A Review. Asian J. Research Chem. 2017; 10(1):6-13. doi: 10.5958/0974-4150.2017.00002.5   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2017-10-1-2


Recomonded Articles:

Synthesis, Characterization and Biological Study of Some Chalcones derived from Terphthaldehyde

Author(s): Suha K. Al-Mosawi, Hanan A. Al-Hazam, Abbas F. Abbas

DOI: 10.5958/0974-4150.2019.00031.2         Access: Open Access Read More

Synthesis, Characterisation, DNA binding/cleavage, anticancer and antimicrobial activity of Ternary Copper(II) Complexes

Author(s): S. Dhakshanamoorthy, M. Murali Krishnan, M.N. Arumugham

DOI: 10.5958/0974-4150.2017.00052.9         Access: Open Access Read More

Structural and Biological Activity Studies on Metal Complexes Containing Thiosemicarbzone and Isatin Based Schiff Base: A Review

Author(s): Saddam Hossain, C. M. Zakaria, Kudrat-E-Zahan

DOI: 10.5958/0974-4150.2017.00002.5         Access: Open Access Read More

Latest Strategy of Medicinal Chemistry Implements In-silico After In-Vivo and In-Vitro

Author(s): Ravi N. Patel, Urviben Y. Patel, Kiran M. Patel, Jimit S. Patel, Ankit D. Patel, Dhrubo Jyoti Sen

DOI:         Access: Open Access Read More

Synthesis and antimicrobial evaluation of Azetidinone derivatives of pyridine containing hydrazides

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Synthesis of Some Chalcone and Their Heterocyclic Derivatives as Potential Antimicrobial Agents: A Review.

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Phytochemical, Pharmacological and Therapeutic Potential of Hordeum vulgare Linn. - A Review

Author(s): Anshul Sinha, A. K. Meena, P. Panda, Bhavana Srivastava, M. D. Gupta, M. M. Padhi

DOI:         Access: Open Access Read More

A Review on Recent Trends in the Bioactive Studies of Pyrazole Derivatives

Author(s): Maddineni Aruna Kumari, Chunduri Venkatarao

DOI: 10.5958/0974-4150.2020.00072.3         Access: Open Access Read More

Schiff base metal complexes: Synthesis, Characterization, Thermal Analysis and Antibacterial Activity

Author(s): Tuly Paul, Faruk Hossen, Kudrat-E-Zahan, Masuqul Haque, Saddam Hossain, Rausan Zamir, Ali Asraf

DOI: 10.5958/0974-4150.2020.00052.8         Access: Open Access Read More

Review on Discovery Studio: An important Tool for Molecular Docking

Author(s): Shravani S. Pawar, Sachin H. Rohane

DOI: 10.5958/0974-4150.2021.00014.6         Access: Open Access Read More

Synthesis and Biological Activities of Some Benzothiazole Derivatives

Author(s): Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S

DOI:         Access: Open Access Read More

Reduction of Schiff Bases with Sodium Borohydride Possessing Antibacterial Activity

Author(s): S.B. Junne, Archana B. Kadam, Archana Y. Vibhute, S.L. Shinde, R.B. Patil, Y.B. Vibhute

DOI:         Access: Open Access Read More

Antibacterial Screening of Clerodendrum infortunatum leaves: Experimental and Molecular docking studies

Author(s): Sindhu. T. J, Akhilesh K. J, Anju. Jose, Binsiya K. P, Blessy Thomas, Elizabeth Wilson

DOI: 10.5958/0974-4150.2020.00026.7         Access: Open Access Read More

Synthesis and In Vitro Antimicrobial Activity of Some New 4-Amino-N-(1,3- Benzothiazol-2-yl) benzenesulphonamide Derivatives

Author(s): KP Bhusari, ND Amnerkar, PB Khedekar, MK Kale, RP Bhole

DOI:         Access: Open Access Read More

Synthesis and Biological Screening of Novel Aminoalkyl Substituted Azaphenothiazine

Author(s): P. Valentina, K. Ilango, Deepak Jain, Prerna Shukla

DOI:         Access: Open Access Read More

Synthesis, spectral and biological studies of Cd (II) complex of Schiff base ligand derived from 3-hydrazinylquinoxalin-2(1H)-one and 2-hydroxy-3-methoxybenzaldehyde

Author(s): P. Sukanya, Ch. Venkata Ramana Reddy

DOI: 10.5958/0974-4150.2017.00010.4         Access: Open Access Read More

Synthesis, characterization and pharmacological evaluation of novel spiro heterocyclic compounds as anti diabetic agents

Author(s): K. Kishore Kumar, R.S.K. Sharma, P. Chanti Babu, M. Sreenivasa Rao, K. Durga Prasadu, D. Ravi Kumar

DOI: 10.5958/0974-4150.2017.00067.0         Access: Open Access Read More

Design, Synthesis, Structural Elucidation and Antimicrobial Screening of Novel 1, 5-Benzothiazepine derivatives Derived from Thieno [3, 2-d] Pyrimidine Nucleus

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, J. Latha, B.Venkateswarlu

DOI: 10.5958/0974-4150.2017.00011.6         Access: Open Access Read More

Synthesis and Characterization of Schiff Base CoII, NiII and CuII Complexes derived from 2-Hydroxy-1-naphthaldehyde and Ethylenediamine

Author(s): Kadhiravansivasamy, S. Sivajiganesan, T. Periyathambi, V. Nandhakumar, M. Pugazhenthi

DOI: 10.5958/0974-4150.2017.00016.5         Access: Open Access Read More

Biodiversity of Oxazolone Derivatives in Medicinal Chemistry: A Review

Author(s): Suman Bala, Minaxi Saini, Sunil Kamboj, Goldie Uppal, Ashok Kumar

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Quick Links


Latest Issues

Popular Articles


Recent Articles



Analysis the Water Quality Parameters of Ground sample with Special Reference to Fluoride in different Locations of Malpura (Tonk District, Rajasthan, India)
A Comprehensive Review for Drug Target on Terminalia arjuna (Roxb.): Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical Significance
Gastro Retentive Drug Delivery System: A Review
A Concise Review on role of QSAR in Drug Design
A Review on the Ethnopharmacology, Phytochemistry and Pharmacology of Natural Phytochemicals used for Ameliorating/preventing SARS-CoV-2
Synthesis and Characterization of Novel Isoxazole derivatives
Chitosan: An Efficient and Eco‐friendly catalyst for one-pot multicomponent access to dihydro-1H-indeno[1,2-b] pyridines
Optimization of Synthetic Condition for 2’hydroxy Chalcone by using Mixture Design
Out-of-Trend Statistics in The Pharmaceutical Industry: A Gain Leap in Assuring the Quality of The product
Determination of the Presence, Concentration, and effects of Formalin on Raw milk around Nyeri Municipality
Triphenylphosphine as an efficient and reusable organocatalyst for the synthesis of substituted pyrano[2,3-c]pyrazoles
Caffeine: An efficient and Reusable catalyst for the multicomponent synthesis of 2-amino-3-cyano-6-methyl-4-aryl-4H-pyrans
In-vitro studies based on Natural compounds with Antitumor properties used for Ameliorating/ Preventing Cancer
Green Analytical UV-VIS Spectrophotometric Method Development of Valsartan by using Hydrotropic agent
Validation of Molnupiravir by Application of Reactive Dyes from Pharmaceutical Dosages
Determination, Method Development and Validation of Six Nitrosamine Impurities in Purified water by using LC-MS/MS
Exploring DNA Binding of Benzothiazole-based Known Drugs: A Molecular Docking Investigation
Application of Chitosan Nanoparticles in the Adsorption of Heavy Metals from Wastewater: A Concise Review
Ethnopharmacological Overview on Natural Lignan and Neolignan for the Treatment of Cardiovascular Diseases and their Potential Pharmacological Mechanism
Conditioning and Germination Control bio-assays of Quercus suber L. acorns under the Allopathic and Residual effects of Volatile Oils and Hydrolates from Aromatic Plants in Northeastern Algeria

Tags


About Journal

Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
Read More  

Visitors

Today: 277
Yesterday: 802
Total: 1224629