Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Synthesis, Characterization of Some Novel Schiff’s bases of 4-((2-methyl-4/5-nitro-1H-imidazol-1-yl) methyl) thiazol-2-amine and their Antimicrobial Activity

Author(s): A. A. Shaikh, M. G. Raghuwanshi

Email(s): arshadshaikh78@rediffmail.com

DOI: 10.5958/0974-4150.2016.00079.1   

Address: A. A. Shaikh1* , M. G. Raghuwanshi2
1Maulana Abulkalam Azad Residential High School and Jr. College, Akkalkuwa. Dist. Nandurbar-425415 (M.S.) India.
2Principal, Science Senior College, Akkalkuwa, Dist. Nandurbar-425415 (M.S.) India.
*Corresponding Author

Published In:   Volume - 9,      Issue - 11,     Year - 2016

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ABSTRACT:
The present work contend with the synthesis, characterization and antimicrobial activity of some novel Schiff’s bases of 4-substituted thiazol-2-amine as five membered heterocyclic compounds. 4-((2-methyl-5-nitro-1H-imidazol-1-yl) methyl) thiazol-2-amine (3) was synthesized by refluxing 1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl) propan-2-one (2) with thiourea using water as solvent. Compound (3) on reaction with substituted benzaldehyde afforded Schiff’s bases (4a-4k). Similarly 4-((2-methyl-4-nitro-1H-imidazol-1-yl) methyl) thiazol-2-amine (7) was synthesized by refluxing 1-chloro-3-(2-methyl-4-nitro-1H-imidazol-1-yl) propan-2-one (6) with thiourea using water as solvent. Compound (7) on reaction with substituted benzaldehyde afforded Schiff’s bases (8a-8k). The chemical structures of synthesized compounds were elucidated on the basis of IR and H-NMR and MASS spectral studies. The synthesized Schiff’s bases (4a-4k) and (8a-8k) were screened for their antibacterial activity against Bacillus subtilis, Pseudomonas aurius using cefixime as standard drug and antifungal activity against Aspergillus niger, Candida albicans, Aspergillus flavus using Clotrimazole as standard drug by agar well diffusion assay method.


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Cite this article:
A. A. Shaikh, M. G. Raghuwanshi. Synthesis, Characterization of Some Novel Schiff’s bases of 4-((2-methyl-4/5-nitro-1H-imidazol-1-yl) methyl) thiazol-2-amine and their Antimicrobial Activity. Asian J. Research Chem. 2016; 9(11): 587-596. doi: 10.5958/0974-4150.2016.00079.1

Cite(Electronic):
A. A. Shaikh, M. G. Raghuwanshi. Synthesis, Characterization of Some Novel Schiff’s bases of 4-((2-methyl-4/5-nitro-1H-imidazol-1-yl) methyl) thiazol-2-amine and their Antimicrobial Activity. Asian J. Research Chem. 2016; 9(11): 587-596. doi: 10.5958/0974-4150.2016.00079.1   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2016-9-11-5


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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