ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Lincy Joseph, Mathew George

Email(s): drlincyjoseph@gmail.com , mathewlincg@gmail.com

DOI: 10.52711/0974-4150.2023.00066   

Address: Lincy Joseph, Mathew George
Holy Queen College of Pharmaceutical Sciences and Research, Puthuruthy, Thrissur - 680623, Kerala.
*Corresponding Author

Published In:   Volume - 16,      Issue - 6,     Year - 2023


ABSTRACT:
Twenty five novel Isoxazole heterocycles are synthesized and characterized by IR, NMR and CHN analysis. Physico-chemical characteristics also notified. In the first step chalcones are synthesized by the reaction of aromatic aldehydes with aromatic ketones in aqueous alcoholic alkaline medium. These are made to react with hydroxylamine hydrochloride and sodium acetate to prepare title compounds. All synthesized compounds analyzed for obedience of Lipinsky’s rule. Six of the compounds showed slight violation to oral dosage form suitability. Most of the compounds were solid in nature and gave good yield.


Cite this article:
Lincy Joseph, Mathew George. Synthesis and Characterization of Novel Isoxazole derivatives. Asian Journal of Research in Chemistry. 2023; 16(6):409-1. doi: 10.52711/0974-4150.2023.00066

Cite(Electronic):
Lincy Joseph, Mathew George. Synthesis and Characterization of Novel Isoxazole derivatives. Asian Journal of Research in Chemistry. 2023; 16(6):409-1. doi: 10.52711/0974-4150.2023.00066   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2023-16-6-2


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