Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Quantitative Structure Activity Relationship of Some Substituted 2-Aminopyridines and Fused Bicyclic Rings as inhibitors of Nitric Oxide Synthases

Author(s): Amol S. Sherikar

Email(s): amol.sherikar@rediffmail.com

DOI: Not Available

Address: Amol S. Sherikar*
Department of Pharmaceutical Chemistry, Tatyasaheb Kore College of Pharmacy, Warananagar, Tal- Panhala, Dist- Kolhapur, Maharashtra, India. 416 113.
*Corresponding Author

Published In:   Volume - 4,      Issue - 10,     Year - 2011

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ABSTRACT:
In the present work, QSAR study has been performed to explore physicochemical requirements of some substituted 2-aminopyridines and fused rings as inhibitors of Nitric Oxide Synthases. QSAR study has been carried out for two isoforms of the Nitric Oxide Synthases (eNOS and nNOS). QSAR models were derived by stepwise multiple regression analysis employing the method of least squares. The best QSAR model describing the Nitric Oxide Synthases inhibitory activity of 2- Aminopyridine and fused bicyclic ring system was selected on the basis of statistical significance and predictive ability as gauged by cross-validation procedure and external test-set method. The statistical quality of generated equations was evaluated considering parameters like correlation coefficient (r), standard error of estimation (SEE), Fischer ratio (F). The predictive ability of models was checked by external test set by calculating Q2. The result of present study may be useful for designing more potent aminopyridine analogues as inhibitors of nitric oxide synthases.


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Cite this article:
Amol S. Sherikar. Quantitative Structure Activity Relationship of Some Substituted 2-Aminopyridines and Fused Bicyclic Rings as inhibitors of Nitric Oxide Synthases. Asian J. Research Chem. 4(10): Oct., 2011; Page 1625-1629.

Cite(Electronic):
Amol S. Sherikar. Quantitative Structure Activity Relationship of Some Substituted 2-Aminopyridines and Fused Bicyclic Rings as inhibitors of Nitric Oxide Synthases. Asian J. Research Chem. 4(10): Oct., 2011; Page 1625-1629.   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2011-4-10-30


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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