ABSTRACT:
Pyrazole derivatives, an essential class of N-heterocycles, have gained significant attention in synthetic and medicinal chemistry due to their broad-spectrum biological activities, including anti-inflammatory, anticancer, antifungal, and antimicrobial properties. Over the years, various synthetic methodologies have been explored to improve the efficiency, selectivity, and sustainability of pyrazole synthesis. Modern approaches involve catalyst-assisted reactions, multicomponent reactions (MCRs), and eco-friendly strategies such as microwave-assisted synthesis, ultrasound-promoted reactions, and solvent-free techniques. The use of transition metals like copper, palladium, and iron has enabled regioselective functionalization of pyrazoles, while green chemistry approaches, including ionic liquid-mediated synthesis and biocatalysis, have enhanced reaction efficiency with reduced environmental impact. Recent advancements also explore the synthesis of pyrazole derivatives using novel catalysts, cascade reactions, and visible light-induced processes. This review provides an overview of the latest trends in pyrazole synthesis, highlighting the role of emerging methodologies in improving reaction yield, sustainability, and pharmaceutical applications.
Cite this article:
Waghamare Suresh. Recent Advances in N-Heterocyclic Chemistry: Innovative Strategies for Pyrazole Derivative Synthesis. Asian Journal of Research in Chemistry. 2025; 18(6):385-1. doi: 10.52711/0974-4150.2025.00059
Cite(Electronic):
Waghamare Suresh. Recent Advances in N-Heterocyclic Chemistry: Innovative Strategies for Pyrazole Derivative Synthesis. Asian Journal of Research in Chemistry. 2025; 18(6):385-1. doi: 10.52711/0974-4150.2025.00059 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2025-18-6-4
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