Author(s):
Pankti Patel, Pushti Patel, Taufik Mulla
Email(s):
mullataufik@gmail.com
DOI:
10.52711/0974-4150.2025.00061 
Address:
Pankti Patel, Pushti Patel, Taufik Mulla*
Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Parul University, P.O. Limda, Tal. Waghodia - 391760, Dist. Vadodara, Gujarat (India).
*Corresponding Author
Published In:
Volume - 18,
Issue - 6,
Year - 2025
ABSTRACT:
Green chemistry, often referred to as sustainable chemistry, aims to design chemical products and processes that minimize or eliminate the use and generation of hazardous substances. In the pharmaceutical industry, where large volumes of reagents, solvents, and energy are used, green chemistry has emerged as a critical approach to achieving environmental, economic, and regulatory goals. The integration of green chemistry principles in pharmaceutical synthesis enhances the efficiency and safety of drug development while reducing waste, toxicity, and energy consumption. This review explores the key green chemistry principles applied in pharmaceutical synthesis, such as atom economy, use of renewable feedstocks, reduction of solvent usage, and energy-efficient methodologies. Particular emphasis is placed on the use of biocatalysis, flow chemistry, solvent-free reactions, and microwave-assisted synthesis as environmentally friendly alternatives to traditional methods. Additionally, the replacement of toxic reagents with greener substitutes, as well as advancements in catalyst design for selective transformations, are discussed. The role of regulatory guidelines and green metrics such as E-factor and process mass intensity (PMI) in guiding greener processes is also reviewed. Ultimately, the adoption of green chemistry in pharmaceutical synthesis not only fosters environmental stewardship but also aligns with cost-effectiveness and innovation in drug manufacturing.
Cite this article:
Pankti Patel, Pushti Patel, Taufik Mulla. Green Chemistry Approaches in Pharmaceutical Synthesis. Asian Journal of Research in Chemistry. 2025; 18(6):401-8. doi: 10.52711/0974-4150.2025.00061
Cite(Electronic):
Pankti Patel, Pushti Patel, Taufik Mulla. Green Chemistry Approaches in Pharmaceutical Synthesis. Asian Journal of Research in Chemistry. 2025; 18(6):401-8. doi: 10.52711/0974-4150.2025.00061 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2025-18-6-6
10. REFERENCE:
1. Priyanka M. Patel, Alka A. Patil, Manisha D. Patil, Pinal S. Patil, S.L.Borse. Green Chemistry -An Overview. Asian J. Research Chem. 2013; 6(7): 705-709.
2. S.Sharma, Tania Bansal, Radhika, Sandeep Kaur, Jyoti. Green Chemistry: An Overview. Asian J. Research Chem. 2013; 6(11): 1075-1084.
3. Surya Prakash BN Gupta, Neeraj Upmanyu, Gopal Garg. Rising Importance of Green Chemistry in India: A Study. Research J. Pharm. and Tech. 2010; 3(2): 627-628.
4. Constable DJC, Curzons AD, Cunningham VL. Metrics to ‘green’ chemistry – which are the best? Green Chem. 2002; 4(6): 521–7.
5. Roschangar F, Sheldon RA, Senanayake CH. Overcoming barriers to green chemistry in the pharmaceutical industry—the Green Aspiration Level™. Green Chem. 2015; 17(2): 752–68.
6. Ahmed I. Hassan. Green Chemistry Approach for Determination of H2-receptor Antagonists in Their Pharmaceutical Dosage Forms with an Optical Probe. Asian J. Pharm. Ana. 2019; 9(1): 19-24.
7. Anastas PT, Warner JC. Green Chemistry: Theory and Practice. Oxford University Press; 1998.
8. Anastas PT, Kirchhoff MM. Origins, current status, and future challenges of green chemistry. Acc Chem Res. 2002; 35(9): 686–94.
9. Sheldon RA. Fundamentals of green chemistry: efficiency in reaction design. Chem Soc Rev. 2012; 41(4): 1437–51.
10. Capello C, Fischer U, Hungerbühler K. What is a green solvent? A comprehensive framework for the environmental assessment of solvents. Green Chem. 2007; 9(9): 927–34.
11. Tufvesson L, Lima-Ramos J, Nordblad M, Woodley JM. Guidelines and cost analysis for catalyst production in biocatalytic processes. Green Chem. 2011; 13(10): 3000–05.
12. Atul R. Bendale, Jayk Khunt, Sushil P. Narkhede, Sachin B. Narkhede, Anil G. Jadhav, G. Vidyasagar. Mechanochemistry - A New Era in Synthesis for Pharmaceutical Researchers. Asian J. Research Chem. 2011; 4(6): 851-856.
13. Li CJ, Chen L. Organic reactions in aqueous media with a focus on carbon–carbon bond formations: A decade update. Chem Soc Rev. 2006; 35(1): 68–82.
14. Jessop PG, Ikariya T, Noyori R. Homogeneous catalysis in supercritical fluids. Chem Rev. 1999; 99(2): 475–93.
15. M. Kavya, D. Priya. Green Chemistry approach for the synthesis of some Benzimidazole derivatives and their Biological Evaluation. Research J. Pharm. and Tech. 2019; 12(3): 1023-1030.
16. Smith EL, Abbott AP, Ryder KS. Deep eutectic solvents (DESs) and their applications. Chem Rev. 2014; 114(21): 11060–82.
17. Bornscheuer UT, Kazlauskas RJ. Catalytic promiscuity in biocatalysis: Using old enzymes to form new bonds and follow new pathways. Angew Chem Int Ed Engl. 2004; 43(45): 6032–40.
18. MacMillan DWC. The advent and development of organocatalysis. Nature. 2008; 455(7211): 304–8.
19. Sourabh D. Jain, Anuja Awasthi, Arun K. Gupta. Green Chemistry: A Sustainable Path to Environmental Responsibility and Innovation. Asian Journal of Research in Pharmaceutical Sciences. Sci. 2024; 14(1): 51-5.
20. Kappe CO. Controlled microwave heating in modern organic synthesis. Angew Chem Int Ed. 2004; 43(46): 6250–85.
21. Mason TJ, Lorimer JP. Applied Sonochemistry: Uses of Power Ultrasound in Chemistry and Processing. Wiley-VCH; 2002.
22. Akshay R. Yadav, Shrinivas K. Mohite. Green Chemistry approach for Microwave assisted synthesis of some Traditional Reactions. Asian J. Research Chem. 2020; 13(4):261-264.
23. Plutschack MB, Pieber B, Gilmore K, Seeberger PH. The Hitchhiker’s Guide to Flow Chemistry. Chem Rev. 2017; 117(18): 11796–893.
24. Patel RN. Biocatalysis: Synthesis of key intermediates for development of pharmaceuticals. ACS Catal. 2011; 1(9): 1056–74.
25. Huffman MA, Fryszkowska A, Alvizo O, et al. Design of an in vitro biocatalytic cascade for the manufacture of sitagliptin. Science. 2010; 328(5981): 1251–55.
26. Schrittwieser JH, Velikogne S, Kroutil W. Biocatalysis: A forward-looking solution in pharmaceutical synthesis. ACS Catal. 2021; 11(5): 2376–91.
27. Mote Bhagyashree, Patil Anuja, Nikam Amit, Rushikesh Sonawane. A Review: Green Chemistry Importance and applications in practice Laboratory. Asian J. Research Chem. 2020; 13(6): 494-496.
28. Tan D, Friščić T. Mechanochemistry for organic chemists: An update. Eur J Org Chem. 2018; 2018(1): 18–33.
29. James SL, Adams CJ, Bolm C, et al. Mechanochemistry: Opportunities for new and cleaner synthesis. Chem Soc Rev. 2012; 41(1): 413–47.
30. Howard JL, Cao Q, Browne DL. Mechanochemistry as an emerging tool for molecular synthesis: What can it offer? Chem Sci. 2018; 9(12): 3080–94.
31. Bolm C, Hernández JG. Mechanochemistry of Gaseous Reactants. Chem Sus Chem. 2018;11(8):1410–19.
32. Do JL, Friščić T. Mechanochemistry: A force of synthesis. ACS Cent Sci. 2017; 3(1): 13–19.
33. Sheldon RA. The E-factor 25 years on: the rise of green chemistry and sustainability. Green Chem. 2017; 19(1): 18–43.
34. Roschangar F, Sheldon RA, Senanayake CH. Overcoming barriers to green chemistry in the pharmaceutical industry. Green Chem. 2015; 17(2): 752–68.
35. Van Aken K, Strekowski L, Patiny L. EcoScale, a semi-quantitative tool to select an organic preparation based on economical and ecological parameters. Beilstein J Org Chem. 2006; 2: 3.
36. International Council for Harmonisation (ICH). ICH Guidelines Q8-Q11. https://www.ich.org
37. U.S. FDA. Emerging Technology Program. https://www.fda.gov
38. Capello C, Fischer U, Hungerbühler K. What is a green solvent? Green Chem. 2007; 9(9): 927–34.
39. Dunn PJ. The importance of green chemistry in process research and development. Chem Soc Rev. 2012; 41(4): 1452–61.
40. Constable DJC, Curzons AD, Cunningham VL. Metrics to ‘green’ chemistry–which are the best? Green Chem. 2002; 4(6): 521–7.
41. Hjeresen D, Boese JL, Schutt D. Green chemistry and education. J Chem Educ. 2000; 77(12): 1543–47.
42. Aishwarya A Jadhav, Rasika P. Devale. Review on Microwave, The General purpose in Microwave Assisted Synthesis for Green Chemistry. Asian Journal of Research in Chemistry. 2022; 15(2): 182-5.
43. Pollard DJ, Woodley JM. Biocatalysis for pharmaceutical intermediates: The future is now. Trends Biotechnol. 2007; 25(2): 66–73.
44. Norman J, Madurawe RD, Moore CMV, Khan MA, Khairuzzaman A. A new chapter in pharmaceutical manufacturing: 3D-printed drug products. Adv Drug Deliv Rev. 2017; 108: 39–50.
45. Bumb A, Rahman S, Khan I. Green chemistry: Future framework for sustainable pharmaceutical manufacturing. Ind Eng Chem Res. 2020; 59(30): 13496–13504.