ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): A. Lakshmana Rao, D. Suneetha

Email(s): dralrao@gmail.com

DOI: Not Available

Address: A. Lakshmana Rao1*and D. Suneetha2
1Vallabhaneni Venkatadri Institute of Pharmaceutical Sciences, Gudlavalleru- 521 356, A.P., India.
2A.K.R.G. College of Pharmacy, Nallajerla- 534 112, A.P., India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 2,     Year - 2012


ABSTRACT:
A simple, rapid, accurate and precise stability indicating RP-HPLC method was developed for the determination of gemifloxacin in pure and tablet dosage forms. Separation of the drug was achieved on a reverse phase Symmetry C18 column. The method showed a linear response for concentration in the range of 10-50 µg/ml using acetate buffer: methanol as the mobile phase in the ratio of 38:62 v/v with detection at 273 nm with a flow rate of 1 ml/min and retention time was 2.044 min. The method was statistically validated for accuracy, precision, linearity, ruggedness, robustness, forced degradation, solution stability and selectivity. Quantitative and recovery studies of the dosage form were also carried out and analyzed, the % RSD from recovery studies was found to be less than 1. Due to simplicity, rapidity and accuracy of the method, we believe that the method will be useful for routine quality control analysis of gemifloxacin in pharmaceutical formulation.


Cite this article:
A. Lakshmana Rao, D. Suneetha. Stability Indicating RP-HPLC Method for the Determination of Gemifloxacin in Pharmaceuticals. Asian J. Research Chem. 5(2): February 2012; Page 200-204.

Cite(Electronic):
A. Lakshmana Rao, D. Suneetha. Stability Indicating RP-HPLC Method for the Determination of Gemifloxacin in Pharmaceuticals. Asian J. Research Chem. 5(2): February 2012; Page 200-204.   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2012-5-2-9


Recomonded Articles:

Author(s): Ravi N. Patel, Urviben Y. Patel, Kiran M. Patel, Jimit S. Patel, Ankit D. Patel, Dhrubo Jyoti Sen

DOI:         Access: Open Access Read More

Author(s): Chavan Pooja Ajit, Avinash Mahadeo Bhagwat, Atul Prabhakar Chaudhari

DOI: 10.52711/0974-4150.2021.00061         Access: Open Access Read More

Author(s): Mukund Nagarnaik, Arun Sarjoshi, Ajay Bodkhe, Bhupendra Khanal, Mayuri Pise, Girish Pandya

DOI: 10.5958/0974-4150.2015.00102.9         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Prasanna Reddy Battu, MS Reddy

DOI:         Access: Open Access Read More

Author(s): Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy

DOI: 10.5958/0974-4150.2016.00076.6         Access: Open Access Read More

Author(s): Nachiket S. Dighe, Priyanka R. Varade, Ganesh S. Shinde, Priya S. Rao

DOI: 10.5958/0974-4150.2019.00028.2         Access: Open Access Read More

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): Sushil D. Patil, Tejashri Dugaje, Sanjay J. Kshirsagar

DOI: 10.5958/0974-4150.2019.00024.5         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags