ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Gopal Muthuboopathi, Thirumurthi Rajendran, Samina Shanawaz, Dhivya Moorthi, Janani Thirunavukkarasu, Nandhini, Vani Saminathan

Email(s): muthubhupathi@gmail.com , saminashammu.92@gmail.com

DOI: 10.52711/0974-4150.2022.00063   

Address: Gopal Muthuboopathi*, Thirumurthi Rajendran, Samina Shanawaz, Dhivya Moorthi, Janani Thirunavukkarasu, Nandhini, Vani Saminathan
Department of Pharmaceutical Chemistry, Vivekananda Pharmacy College for Women, Sankari – 637303.
*Corresponding Author

Published In:   Volume - 15,      Issue - 5,     Year - 2022


ABSTRACT:
Contemporary pharmaceutical chemistry faces several challenges in different directions, including the need for both the potency and specificity of any therapeutic agent. The increasingly demanding low toxicity requirements observed in all patients treated and the need for novelty in intellectual property, given the extensive use of benzenoid and heteroaromatic ring systems in many patents. Such challenges are increasingly met by moving to new and / or unusual ring systems (scaffolds) that lie outside the realm of (hetero) aromatic systems. This critical review examines the biological activities of Thiazolidine derivatives like anti-microbial, anti-cancer, anti-diabetics, antiobesity, anti-oxidant by giving mechanistic insights of the given atypical scaffolds from mainly drawn from the literature of the last five years, which have found applications in modern bioorganic chemistry and Medicinal Chemistry.


Cite this article:
Gopal Muthuboopathi, Thirumurthi Rajendran, Samina Shanawaz, Dhivya Moorthi, Janani Thirunavukkarasu, Nandhini, Vani Saminathan. Research Critique of Thiazolidine Analogues. Asian Journal of Research in Chemistry. 2022; 15(5):351-7. doi: 10.52711/0974-4150.2022.00063

Cite(Electronic):
Gopal Muthuboopathi, Thirumurthi Rajendran, Samina Shanawaz, Dhivya Moorthi, Janani Thirunavukkarasu, Nandhini, Vani Saminathan. Research Critique of Thiazolidine Analogues. Asian Journal of Research in Chemistry. 2022; 15(5):351-7. doi: 10.52711/0974-4150.2022.00063   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2022-15-5-9


REFERENCE:
1.    Srikanth Kumar, K., Lakshmana Rao, A., and Sekhara Reddy, D. R. Design, Synthesis, Hypoglycemic Activity and Molecular Docking Studies of 3-substituted-5- [(furan-2-yl)-methylene]-thiazolidine-2,4-dione Derivatives. Indian Journal of Pharmaceutical Education and Research. 2021;55(1), 266–275. https://doi.org/10.55305/ijper.55.1.30
2.    National Center for Biotechnology Information. PubChem Compound Summary for CID 10444, Thiazolidine. (2021;https://pubchem.ncbi.nlm.nih.gov/compound/Thiazolidine.
3.    De Monte, C., Carradori, S., Bizzarri, B., Bolasco, A., Caprara, F., Mollica, A., Rivanera, D., Mari, E., Zicari, A., Akdemir, A., and Secci, D. Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives. European Journal of Medicinal Chemistry. 2016; 107, 82–96. https://doi.org/10.1016/j.ejmech.2015.10.048
4.    Sriram,D., Yogeeshwari,P., Kumar., A.TG. Microwave-assisted synthesis and anti YFV activity of 2,3-diaryl-1-3-thiazolidin-4-one. J Pharmaceut Sci. 2005;8 (3): 426-429.
5.    Pires Gouvea, D., Vasconcellos, F. A., dos Anjos Berwaldt, G., Neto, A. C. P. S., Fischer, G., Sakata, R. P., Almeida, W. P., and Cunico, W. 2-Aryl-3-(2-morpholinoethyl)thiazolidin-4-ones: Synthesis, anti-inflammatory in vivo, cytotoxicity in vitro and molecular docking studies. European Journal of Medicinal Chemistry. 2016;118, 259–265. https://doi.org/10.1016/j.ejmech.2016.04.028
6.    Sucheta, Tahlan, S., and Verma, P. K. Synthesis, SAR and in vitro therapeutic potentials of thiazolidine-2,4-diones. Chemistry Central Journal. 2018;12(1). https://doi.org/10.1186/s13065-018-0496-0
7.    Gayam, K. R., and Palaniappan, S. Design, Synthesis and Antimicrobial Activity of 2-Aromatic Substituted-1,3-Thaizolidine Derivatives. American Journal of Pharmacy and Health Research. 2019; 7(8), 22–36. https://doi.org/10.46624/ajphr.2019.v7.i8.003
8.    Shinde, P. N., and Raskar, M. A.Synthesis and Biological Evaluation of Spiro (Indole -Thiazolidine) Derivatives as Antimicrobial Agents. International Journal of Current Pharmaceutical Research. 2019; 71–74. https://doi.org/10.22159/ijcpr.2019v11i6.36346
9.    Marc, Araniciu, Oniga, Vlase, Pîrnău, Nadăș, Novac, Matei, Chifiriuc, Măruțescu, and Oniga. Design, Synthesis and Biological Evaluation of New Piperazin-4-yl-(acetyl-thiazolidine-2,4-dione) Norfloxacin Analogues as Antimicrobial Agents. Molecules. 2020; 24(21), 3959. https://doi.org/10.3390/molecules24213959
10.    Khedr, M. A., Al-Wabli, R. I., Almutairi, M. S., and Zaghary, W. A.. QSAR-based rational discovery of novel substituted-4′-iminospiro[indoline-3,3′-[1,2,5]thiadiazolidinyl]-2-one 1′,1′-dioxide with potent in vitro anticancer activity. BMC Chemistry. 2019;13(1). https://doi.org/10.1186/s13065-019-0520-z
11.    Kalpana Tilekar, K., Upadhyay, N., Hess, J. D., Macias, L. H., Mrowka, P., Aguilera, R. J., Meyer-Almes, F.-J., Iancu, C. V., Choe, J.-yong, and Ramaa, C. S. Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of Glut 1 and Glut 4, and evaluation of their anti-leukemic potential. European Journal of Medicinal Chemistry. 2022 ;02, 112603. DOI:10.1016/j.ejmech.2020.112603
12.    Abdellatif, K. R., Fadaly, W. A., Kamel, G. M., Elshaier, Y. A., and El-Magd, M. A. Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors. Bioorganic Chemistry. 2019;82, 86–99. DIO:10.1016/j.bioorg.2018.09.034
13.    Bansal, G., Thanikachalam, P. V., Maurya, R. K., Chawla, P., and Ramamurthy, S. An overview on medicinal perspective of thiazolidine-2,4-dione: A remarkable scaffold in the treatment of type 2 diabetes. Journal of Advanced Research. 2020;23, 163–205. DIO:10.1016/j.jare.2020.01.008
14.    Mohd Siddique, M. U., Thakur, A., Shilkar, D., Yasmin, S., Halakova, D., Kovacikova, L., Prnova, M. S., Stefek, M., Acevedo, O., Dasararaju, G., Devadasan, V., Mondal, S. K., and Jayaprakash,V.Non-carboxylic acid inhibitors of aldose reductase based on N? substituted thiazolidinedione derivatives. European Journal of Medicinal Chemistry. 2021;223, 113630. DOI: 10.1016/j.ejmech.2021.113630.
15.    Patel, S., Sen, A. K., Dash, D. K., Sadhu, P., Kumari, M., and Baile, S. B.Synthesis, Characterization and Biological Evaluation of Thiazolidinedione Derivative as Novel Antidiabetic Agents. Journal of Pharmaceutical Research International. 2021c; 123–133. DIO:10.9734/jpri/2021/v33i35a31881
16.    Incerti, M., Crascì, L., Vicini, P., Aki, E., Yalcin, I., Ertan-Bolelli, T., Cardile, V., Graziano, A., and amp; Panico, A.g. 4-thiazolidinone derivatives as MMP inhibitors in tissue damage: Synthesis, biological evaluation and Docking Studies. Molecules. 2018;23(2), 415. DOI :10.3390/molecules23020415.
17.    Vasincu, I. M., Apotrosoaei, M., Constantin, S., Butnaru, M., Vereștiuc, L., Lupușoru, C. E., Buron, F., Routier, S., Lupașcu, D., Taușer, R. G., and Profire, L. (2021). New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile. BMC Pharmacology and Toxicology. 2021; 22(1).DIO:10.1186/s40360-021-00475-0.
18.    Malik, Z., Abbas, M., Al Kury, L. T., Shah, F. A., Alam, M., Khan, A.-ullah, Nadeem, H., Alghamdi, S., Sahibzada, M. U., and Li, S.Thiazolidine derivatives attenuate carrageenan-induced inflammatory pain in mice. Drug Design, Development and Therapy. 2021; Volume15 369–384. DOI: 10.2147/dddt.s281559.
19.    Carradori, S., Secci, D., Bizzarri, B., Chimenti, P., De Monte, C., Guglielmi, P., Campestre, C., Rivanera, D., Bordón, C., and amp; Jones-Brando, L.. Synthesis and biological evaluation of anti-toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1), 746–758 DOI: 10.1080/14756366.2017.1316494.
20.    George, G., Auti, P. S., and amp; Paul, A. T.Design, synthesis, in silico molecular modelling studies and biological evaluation of novel indole-thiazolidinedione hybrid analogues as potential pancreatic lipase inhibitors. New Journal of Chemistry. 2020; 45(3), 1381–1394. DOI:10.1039/d0nj05649a.

Recomonded Articles:

Author(s): Kateryna Taran, Ayaou Abderrahim, Vera Kravchenko, Olena Novosel, Svitlana Taran

DOI: 10.5958/0974-4150.2020.00034.6         Access: Open Access Read More

Author(s): Ravi N. Patel, Urviben Y. Patel, Kiran M. Patel, Jimit S. Patel, Ankit D. Patel, Dhrubo Jyoti Sen

DOI:         Access: Open Access Read More

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Anshul Sinha, A. K. Meena, P. Panda, Bhavana Srivastava, M. D. Gupta, M. M. Padhi

DOI:         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags