ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Wende-Konté Hazael Conania Nikiema, Yssouf Karanga, Ousmane Ilboudo, Téeda Hamidou Ganamé, Issa Tapsoba

Email(s): issa.tapsoba@gmail.com

DOI: 10.52711/0974-4150.2023.00043   

Address: Wende-Konté Hazael Conania Nikiema1, Yssouf Karanga1,2, Ousmane Ilboudo1, Téeda Hamidou Ganamé1, Issa Tapsoba1*
1Laboratoire de Chimie Analytique Environnementale et Bio-organique (LCAEBiO), Département de Chimie, Unite de Formation et de Recherche en Sciences Exactes et Appliquées (UFR/SEA),
Université Joseph KI-Zerbo, 03 BP 7021 Ouagadougou 03, Burkina Faso.
2Laboratoire de Chimie Analytique, de Physique Spatiale et Energétique (L@CAPSE) Université Norbert ZONGO, Avce Maurice Yameogo, Koudougou BP 376, Burkina Faso.
*Corresponding Author

Published In:   Volume - 16,      Issue - 4,     Year - 2023


ABSTRACT:
Medicinal plants are recognized as a source of active molecules that can treat several diseases. Cassia occidentalis (C. occidentalis) is a medicinal plant traditionally used in rural areas of Burkina Faso for the treatment of diabetes. The objective of this work is to evaluate the antioxidant and antidiabetic properties of the fractions of this plant. The antidiabetic activity was investigated by following the inhibitory effect of the different fractions of plant extract on a-glucosidase. The antioxidant activities were performed using 2, 2-diphenyl-1-picryl-hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods. TLC analysis revealed the presence of quercetin in the ethyl acetate fractions of stems and leaves of C. occidentalis. Ethyl acetate fractions of stems and leaves of C. occidentalis demonstrated significant antidiabetic properties with IC50 values ca. 0.274 ± 0.003 and 0.538 ± 0.011 mg/mL respectively compared to the reference acarbose with IC50 ca. 0.215 ± 0.004 mg/mL. The same fractions exhibited respectively the highest FRAP values close to 167.055 ± 0.008 and 128.490 ± 5.227 µg ET/mg and DPPH values of 114.062 ± 2.698 and 82.962 ± 3.189 µg ET/mg. Phytochemical screening revealed the presence of flavonoids, tannins and quinones. These results show that C. occidentalis possess molecules with interesting antidiabetic properties and demonstrate its use in the treatment of diabetes.


Cite this article:
Wende-Konté Hazael Conania Nikiema, Yssouf Karanga, Ousmane Ilboudo, Téeda Hamidou Ganamé, Issa Tapsoba. Inhibition of α-glucosidase activity by polyphenol compounds from C. occidentalis: Phytochemical screening and antidiabetic studies. Asian Journal of Research in Chemistry 2023; 16(4):257-4. doi: 10.52711/0974-4150.2023.00043

Cite(Electronic):
Wende-Konté Hazael Conania Nikiema, Yssouf Karanga, Ousmane Ilboudo, Téeda Hamidou Ganamé, Issa Tapsoba. Inhibition of α-glucosidase activity by polyphenol compounds from C. occidentalis: Phytochemical screening and antidiabetic studies. Asian Journal of Research in Chemistry 2023; 16(4):257-4. doi: 10.52711/0974-4150.2023.00043   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2023-16-4-2


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