Author(s):
Abhijeet Shedmake, Priyanka Jadhav, Suvidha Mane, Vaibhavi Rao, Avinash Bhagwat, Vivekkumar Redasani
Email(s):
abhijeetshedmake570@gmail.com
DOI:
10.52711/0974-4150.2023.00061 
Address:
Abhijeet Shedmake*, Priyanka Jadhav, Suvidha Mane, Vaibhavi Rao, Avinash Bhagwat, Vivekkumar Redasani
Department of Pharmacy, YSPM’s, YTC, Faculty of Pharmacy, Satara, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 5,
Year - 2023
ABSTRACT:
N-nitroso dimethylamine (NDMA) and some other N-nitrosamines has been detected as potent mutagenic and carcinogenic arising in purified water due to the use of potable water required for production of purified water. The dominating precursors of N-nitrosamines formation during the purified water disinfection process are secondary and tertiary amines. NDMA is a disinfection of product found by the ozonation and chlorination of purified water. A high-performance liquid chromatography tandem mass spectrometry was developed to study the appearance of N-nitrosamines in purified water. The compounds were detected by Atmospheric Pressure Chemical Ionization (APCI) or Electrospray Ionization (ESI) which are the ionization modes with multiple reaction monitoring mode. Chromatographic separation was performed on a Phenomenex kinetex F5 column having the size 250 × 4.6mm, 5µ. This study proves that NMBA, NDMA, NDEA, NEIPA, NDIPA and NDBA detected in the purified water. Finally, the developed analytical method was strongly applied to the analysis of N-nitrosamines in purified water.
Cite this article:
Abhijeet Shedmake, Priyanka Jadhav, Suvidha Mane, Vaibhavi Rao, Avinash Bhagwat, Vivekkumar Redasani. Determination, Method Development and Validation of Six Nitrosamine Impurities in Purified water by using LC-MS/MS. Asian Journal of Research in Chemistry. 2023; 16(5):377-2. doi: 10.52711/0974-4150.2023.00061
Cite(Electronic):
Abhijeet Shedmake, Priyanka Jadhav, Suvidha Mane, Vaibhavi Rao, Avinash Bhagwat, Vivekkumar Redasani. Determination, Method Development and Validation of Six Nitrosamine Impurities in Purified water by using LC-MS/MS. Asian Journal of Research in Chemistry. 2023; 16(5):377-2. doi: 10.52711/0974-4150.2023.00061 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2023-16-5-11
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