ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sathish Kumar Mittapalli, J N Narendra Sharath Chandra, Jay Prakash Soni, Ram Babu Tripathi, Iffath Rizwana

Email(s): sattisuma@gmail.com

DOI: 10.52711/0974-4150.2024.00004   

Address: Sathish Kumar Mittapalli1*, J N Narendra Sharath Chandra2, Jay Prakash Soni1, Ram Babu Tripathi1, Iffath Rizwana2
1Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University, Gwalior, Madhya Pradesh, India 474020.
2Dean, School of Pharmacy G H Raisoni University, Amravati, Maharashtra, India 444701.
3Department of Pharmaceutical Chemistry, Deccan School of Pharmacy,
Nampally, Hyderabad, Telangana, India 500012.
*Corresponding Author

Published In:   Volume - 17,      Issue - 1,     Year - 2024


ABSTRACT:
More than 100 nations in Africa, the Americas and the Eastern Mediterranean have endemic dengue and malaria, and these bites have the potential to have inflammatory or infectious local or systemic effects. The mosquito repellents from various sources were examined and plant repellents, researchers frequently exaggerate toxicity of the mentioned compound, alleging that it poses a threat to human health or even the environment and reported by recent studies. The aim of the research article, the historical developmental strategies of synthetics and natural and those acts on certain targets as repellent property, target discovery aims to identify and validate appropriate pharmacological targets for therapeutic interventions and establishment of correlations between the molecule and its potency as repellent using various physicochemical parameters and in silico studies. From this study proved that some of the natural compounds were potent in comparison with the some of the standard insect repellents and the paradigm offers a wide variety of prospects that will fasten the lead molecular modifications influences the novel targets and ultimately result in the optimization of the molecular properties by considering the all the methodologies leads to design novel molecules.


Cite this article:
Sathish Kumar Mittapalli, J N Narendra Sharath Chandra, Jay Prakash Soni, Ram Babu Tripathi, Iffath Rizwana. Virtual Screening and Pharmacophore Modeling for discovery of Biologically Active Natural Products as Inhibitors of Odorant-binding Proteins. Asian Journal of Research in Chemistry. 2024; 17(1):17-4. doi: 10.52711/0974-4150.2024.00004

Cite(Electronic):
Sathish Kumar Mittapalli, J N Narendra Sharath Chandra, Jay Prakash Soni, Ram Babu Tripathi, Iffath Rizwana. Virtual Screening and Pharmacophore Modeling for discovery of Biologically Active Natural Products as Inhibitors of Odorant-binding Proteins. Asian Journal of Research in Chemistry. 2024; 17(1):17-4. doi: 10.52711/0974-4150.2024.00004   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2024-17-1-4


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