ABSTRACT:
A simple rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of emtricitabine from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.999) between 10 % to 60 % of 200 mg of drug substance weight. The percentage recovery of emtricitabine in the optimized method was between 99.62 to 99.78 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
Cite this article:
Rajan V. Rele, Prathamesh P. Tiwatane. A Non-aqueous Potentiometric Titration Method for Validation of Emtricitabine from Pharmaceutical Dosages. Asian Journal of Research in Chemistry. 2024; 17(4):199-2. doi: 10.52711/0974-4150.2024.00036
Cite(Electronic):
Rajan V. Rele, Prathamesh P. Tiwatane. A Non-aqueous Potentiometric Titration Method for Validation of Emtricitabine from Pharmaceutical Dosages. Asian Journal of Research in Chemistry. 2024; 17(4):199-2. doi: 10.52711/0974-4150.2024.00036 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2024-17-4-3
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