ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Kizito Onyedikachi Eberendu, Ifeanyi Edozie Otuokere

Email(s): eberendu.kizito@mouau.edu.ng , ifeanyiotuokere@mouau.edu.ng

DOI: 10.52711/0974-4150.2024.00045   

Address: Kizito Onyedikachi Eberendu1*, Ifeanyi Edozie Otuokere2
1Department of Chemical Sciences, Spiritan University, Nneochi Abia State, Nigeria.
2Department of Chemistry, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria.
*Corresponding Author

Published In:   Volume - 17,      Issue - 5,     Year - 2024


ABSTRACT:
A series of complexes of the type [ML2Cl2], where L=6-tert-butyl-4-{[1-(2-methoxyphenyl)ethylidene]amino}-3-(methylsulfanyl)-1,2,4-triazin-5(4H)-one (TBMO) and 4-{[(E)-(2-methoxyphenyl)methylidene]amino}-3-methyl-6-phenyl-1,2,4-triazin-5(4H)-one (MMAO), M=Cu(II), Co(II), Ni(II) and Zn(II), have been synthesized and characterized on the basis of elemental analysis, thermal analysis, molar conductivity, magnetic moment, electronic, infrared, 1H-NMR spectral studies. The findings are in accordance with bidentate chelation of the ligand using nitrogen donors from rings and azomethine. These Hydrazones and their complexes have also been screened for their antibacterial (Bacillus subtilis, Bacillus stearothermophilus, Escherichia coli and Salmonella typhi) and antifungal activities (Aspergillus niger and Aspergil- lus flavus).


Cite this article:
Kizito Onyedikachi Eberendu, Ifeanyi Edozie Otuokere. Synthesis, Characterization and Antimicrobial Studies of Transition Metal Complexes with Triazine-5-hydrazones of o-anisaldehydeAsian Journal of Research in Chemistry.2024; 17(5):257-3. doi: 10.52711/0974-4150.2024.00045

Cite(Electronic):
Kizito Onyedikachi Eberendu, Ifeanyi Edozie Otuokere. Synthesis, Characterization and Antimicrobial Studies of Transition Metal Complexes with Triazine-5-hydrazones of o-anisaldehydeAsian Journal of Research in Chemistry.2024; 17(5):257-3. doi: 10.52711/0974-4150.2024.00045   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2024-17-5-1


REFERENCES:
1.    Govindarao Kamala, N. Srinivasan, K. Ravi Shankar, R. Suresh. Synthesis, Characterization and Antimicrobial Evaluation of N-Mannich Bases of (2- Substituted Phenyl) Benzimidazole Derivatives. Asian J. Pharm. Res. 2018; 8(2): 87-93.
2.    Shao, B. and Aprahamian, I. Hydrazones as new molecular tools. Chem.2020; 6: 2162–2173.
3.    Otuokere, I.E. and Amadi, K.C. (2016). Synthesis, characterization and antidiabetic studies of Co(II) glimepiride complex. International Journal of Research in Engineering and Innovation. 2016; 1(3): 75-80.
4.    Dinda, S. Sultana, T. Sultana, S. Patra, S.C. Mitra, A.K. Roy, S. Pramanik, K. and Ganguly, S. Ruthenocycles of benzothiazolyl and pyridyl hydrazones with ancillary PAHs: Synthesis, structure, electrochemistry and antimicrobial activity. New J. Chem. 2020; 44: 11022–11034.
5.    H.H.S Zaidi, Abdul H., and Abo N.B.R. (2018). Properties and Uses of Substituted Hydrazones’. Journal of Pharmaceutical and Applied Chemistry. 2018; 4(1): 17-21. http://dx.doi.org/ 10.18576/jpac/040103
6.    J. Wahbeh, and Milkowski S.The Use of Hydrazones for Biomedical Applications. SLAS Technology. 2019; 24(2): 161–168. https://doi10.1177/2472630318822713.journals.sagepub.com/home/jla.
7.    Syeda Huma H. Zaidi, Abdul Hai and B. R. Abo Nawar (2018). Properties and Uses of Substituted Hydrazones. Journal of Pharmaceutical and Applied Chemistry. 2018; 4(1): 17-21
8.    R. S. Kalkotwar, R. B. Saudagar. Design, Synthesis and antimicrobial, anti-inflammatory, Antitubercular activities of some 2,4,5-trisubstituted imidazole derivatives. Asian J. Pharm. Res. 2013; 3(4):159-165.
9.    H. Sahebalzamani, Farshid S., and Elmira D. Theoretical Studies of Structure, Spectroscopy, and Properties of a New Hydrazine Derivative. Journal of Chemistry. 2013. https://doi.org/10.1155/ 2013/187974
10.    Fallas J. A., L. González, and I. Corral. Density functional theory rationalization of the substituent effects in trifluoromethyl-pyridinol derivatives. Tetrahedron. 2009; 65(1): 232–239.
11.    Liaw W. F., Lee N. H., Chen C. H., Lee C. M., Lee G. H., and Peng S. M. Dinuclear and mononuclear iron(II)-thiolate complexes with mixed CO/CN- ligands: synthetic advances for iron sites of [Fe]-only hydrogenases. Journal of the American Chemical Society. 2000; 122(3): 488–494.
12.    B. Rosmita, Kumar, A., De, A.K. and Lal, R.A. Synthesis, characterization and electrochemical properties of Copper (II) complexes Derived from Succinoyldihydrazine Schiff base ligands. Arabian Journal of Chemistry. 2015 https:// doi.20.10.1016/j.arabjc.2014.12.040
13.    Hitesh V. Shahare, Rakesh D. Amrutkar. Synthesis, Characterization and Antimicrobial Activity of Diphenylamino Isoxazoline Derivatives. Asian J. Pharm. Res. 2018; 8(3): 148-150.
14.    Mohapatra R. K., Mishra U. K., Mishra S. K., Mahapatra A., and Dash D. C. Synthesis and Characterization of Transition Metal Complexes with Benzimidazolyl-2-hydrazones of o-anisaldehyde and Furfural. Journal of the Korean Chemical Society. 201; 155(6): 926–931.
15.    K.O Eberendu. Spectrophotometric study of Stability Constants of 2z-2-Benzylidenehydrazinecarbothioamide-Mn Schiff Base Complex at Different Temperatures. Research Journal of Science and Technology. 2017; 9(2): 249-252. https://10.5958/2349-2988.2017.00045.6
16.    Eberendu, K.O. and Otuokere, I.E. Complexation Behavior of 1-Phenyl-2,3-dimethyl-4-(benzylamino) pyrazol-5-one Schiff Base Ligand with Manganese ion. Research J. Science and Tech. 2016; 8(4): 199-203
17.    Otuokere, I.E., Sokwaibe, C.E. and Omosun N.N. Iron (II) complex of 1-(5-hydroxyl-3-methyl-1-phenyl-1H-pyrazol-4-yl) octadecan-1-one: synthesis and anti-prostatic hyperplasia activity. ANACHEM Journal. 2017; 7(1): 1341 – 1349.
18.    Otuokere, I.E., Onyenze, U. A. I. Obike, A.I., Ahamefula, A.A., Okafor, G.U. Synthesis, characterization and antibacterial studies of Co(II) and Fe(II) mixed ligand complexes of ciprofloxacin and ascorbic acid. Journal of Environment and Life Sciences. 2017; 2 (1): 12-20.
19.    Otuokere, I.E, Onyinye, U.A, Nwadire, F.C, Nwankwo C.I, Nwachukwu, J.E, Wisdoma C. and Ogbonna A.B. GC-MS Profiling and In Silico Studies to Identify Potential SARS-CoV-2 Nonstructural Protein Inhibitors from Psidium guajava. African Scientific Reports. 2022; 1: 161–173
20.    Onyenze U., Otuokere, I.E and Igwe, J.C. Co(II) and Fe(II) mixed ligand complexes of Pefloxacin and Ascorbic acid: Synthesis, Characterization and Antibacterial Studies, Research J. Science and Tech. 2016; 8(4): 215-220.
21.    K.O Eberendu, Onwu F.K. Synergistic Effect of Halide Ions on the Corrosion Inhibition of Zinc in Hydrochloric Acid using Schiff base compound, 1-phenyl-2,3-dimethyl-4-(benzylamino)pyrazole-5-one. Research Journal of Science and Technology. 2017; 9(2): 244-248. https://10.5958/2349-2988.2017.00044.4
22.    Muhammad Raza Shah, Imdad Ali, Riaz Ullah. Peer Abdul Hannan, and Hidayat Hussain. Synthesis and Characterization of Novel Hydrazone Derivatives of Isonicotinic Hydrazide and Their Evaluation for Antibacterial and Cytotoxic Potential. Molecules, 2022; 27(19): 6770.
23.    M. Akbar Ali, and Livingstone, S.E., Metal complexes of sulphur-nitrogen chelating agents, Coordination Chemistry Reviews. 1974; 13(2–3): 101-132, https://doi.org/10.1016/S0010-8545(00)80253-2. Accessible from (https://www.sciencedirect.com/science/article/pii/S0010854500802532)
24.    R.K, Mohapatra, Mishra, U. K., Mishra, S. K., Mahapatra, A., and Dash, D. C. Synthesis and Characterization of Transition Metal Complexes with Benzimidazolyl-2-hydrazones of o-anisaldehyde and Furfural. Journal of the Korean Chemical Society. 2011; 55(6): 926–931. https://doi.org/10.5012/ JKCS.2011.55.6.926
25.    Masrat Bashir, Aijaz A. Dar, and Imtiyaz Yousuf. Syntheses, Structural Characterization, and Cytotoxicity Assessment of Novel Mn(II) and Zn(II) Complexes of Aroyl-Hydrazone Schiff Base Ligand. ACS Omega. 2023; 8(3): 3026–3042.
26.    Liu, R.X. Wu, Y.S. Liu, Y.C. Luo, R.Y. Yang, L.-D. Tang, M.-T. Chen, Z.-F. and Liang H. New anthrahydrazone derivatives and their cisplatin-like complexes: Synthesis, antitumor activity and structure–activity relationship. New J. Chem. 2019; 43: 18685–18694.
27.    Lima L.M, Frattani F.S, Dos Santos J.L, Castro H.C, Fraga C.A and Zingali R.B. Synthesis and anti‑platelet activity of novel arylsulfonate – Acylhydrazone derivatives, designed as antithrombotic candidates. European Journal of Medicinal Chemistry. 2008; 43: 348‑56.
28.    Kucukguzel S.G., Mazi A., Sahin F., Ozturk S, Stables J. P., Synthesis and biological activity of 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds “European Journal of Medicinal Chemistry. 2006; 38(11): 1005-1013.
29.    Ram Vishun Prasad, Ashutosh Singh. Synthesis, Characterization, Antibacterial and Antifungal study of Novel Co (II) metal complexes of bidentate 3-Formylchromone based Schiff bases. Asian Journal of Pharmaceutical Research. 2022; 12(3): 203-6.
30.    Khan K.M, Khan M, Ali M, Taha M, Rasheed S, Perveen S. and. (2009) Synthesis of bis‑Schiff bases of isatins and their antiglycation activity. Journal of Bioorganic and Medicinal Chemistry. 2009; 17: 7795‑801.
31.    Haba Pokpa, Farba Bouyagui Tamboura, Adama S.Y., Mamour Sarr, Madina Diallo Ba, Ibrahima Elhadji Thiam, Mohamed Gaye, Pascal Retailleau, and Javier Ellena. Synthesis, structural study and X-ray structure determination of transition metal complexes of 4-phenyl-1-(1-(pyridin-2-yl) ethylidene) thiosemicarbazide. Journal of Applied Chemistry (IOSR-JAC). 2019; 12(8): 2278-5736.
32.    Suaad M. Abuskhuna, Talal H. Zeglam, Omran N. R. Fhid, Asma O. Jebril. Antibacterial Activity of Hydroxyimidazole Derivatives. Asian J. Pharm. Tech. 2020; 10(1): 7-10.
33.    Swapna S Kulkarni, AP Mehere, Priyank A Shenoy. Synthesis and In-Vitro Antimicrobial Activity of 4-(Piperazin-1-Ylcarbonyl) Aniline – An Amide Derivative of P-Aminobenzoic Acid. Asian J. Research Chem. 2009; 2(3): 300-303.
34.    Kumawat Deepak, Goswami Raksha, Pathak Saurabh, Gupta Durgesh Kumari, Dwivedi Sunil Kumar, Chaturvedi S. C. Molecular Modeling Study of Some β-Ketoacyl-acyl Carrier Protein Synthase III Inhibitors as Antibacterial Agents. Asian J. Res. Pharm. Sci. 2019; 9(4): 253-259.
35.    Sindhu. T. J, Arathi. K. N, Akhila Devi, Aswathi. T. A, Noushida. M, Midhun. M, Sajil Saju Kuttiyil. Synthesis, Molecular Docking and Antibacterial Studies of Novel Azole derivatives as Enoyl ACP Reductase Inhibitor in Escherichia coli. Asian J. Res. Pharm. Sci. 2019; 9(3): 174-180.
36.    SN Pandeya, Vaishali Mishra, Alka Pandey, Ritu Srivastava. Synthesis and Biological Activity of N-(1-Alkyl-4-Phenyl-6-Thioxo-1, 6-Dihydro-1, 3, 5-Triazine-2-Yl)-N-Arylidine Hydrazine. Asian J. Research Chem. 2010; 3(1): 36-39.
37.    K.T. Joshi, J.M. Patel, A.M. Pancholi, D.A. Shukla. Thermodynamic Parameters of Some Transition Metal ion Complexes of Some Substituted Hydrazones and Their Antibacterial Activity. Asian J. Research Chem. 2011; 4(6): 932-935.
38.    S. Shanthi, J. Stella. Synthesis, Characterization and Antibacterial Activity of Complexes of Transition Metal Ions with Schiff Base Derived from Salicylaldehyde and p-Methoxy Aniline. Asian J. Research Chem. 2011; 4(1): 84-87.


Recomonded Articles:

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Author(s): Anupam Maurya, Subash C. Verma, Vijay Gupta, M. B. Shankar

DOI: 10.5958/0974-4150.2017.00142.0         Access: Open Access Read More

Author(s): Kumaraswamy Gullapelli, M. Ravichander, P. Bhaskar, K. Jagadeesh Babu, G. Brahmeshwari

DOI: 10.5958/0974-4150.2017.00083.9         Access: Open Access Read More

Author(s): Gandra Sandhya, Garepalli Ganga Sravanthi

DOI: 10.5958/0974-4150.2018.00022.6         Access: Open Access Read More

Author(s): Surendra Nath Pandeya, Rajeev Kumar, Gopal Nath, Ashish Kumar Pathak

DOI:         Access: Open Access Read More

Author(s): Mitali A. Patel, Niraj Vyas

DOI:         Access: Open Access Read More

Author(s): Dibyajyoti Saha, Milan Hait

DOI:         Access: Open Access Read More

Author(s): SN Pandeya, Vaishali Mishra, Alka Pandey, Ritu Srivastava

DOI:         Access: Open Access Read More

Author(s): Ankush Garg, Radhika Maheshwari, Pooja Chawla, Shubhini A. Saraf

DOI:         Access: Open Access Read More

Author(s): S. B. Jadhav, P. Y. Shirodkar

DOI:         Access: Open Access Read More

Author(s): Balaraju V,, Yadaiah S, Ramchander Merugu, M. Jyothi , Laxminarayana Eppakayala

DOI: 10.5958/0974-4150.2018.00108.6         Access: Open Access Read More

Author(s): Deepak Kumar Basedia, Birendra Shrivastava, B. K. Dubey, Pankaj Sharma

DOI:         Access: Open Access Read More

Author(s): Dilesh Indorkar, O.P. Chourasia, M. Ahirwar, S.N. Limaye

DOI:         Access: Open Access Read More

Author(s): Roopa H.R., Saravanan J., Mohan S., Rekha Parmesh

DOI:         Access: Open Access Read More

Author(s): H R Roopa, J. Saravanan

DOI:         Access: Open Access Read More

Author(s): Sachin Malik, Ashish Choudhary

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags