ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Swathi N, Subrahmanyam CVS, Satyanarayana K

Email(s): swa.pharma@gmail.com

DOI: 10.5958/0974-4150.2015.00005.X   

Address: Swathi N1,2,*, Subrahmanyam CVS3 and Satyanarayana K4
1Department of Pharmaceutical Chemistry, Gokaraju Rangaraju College of Pharmacy, Hyderabad, 500090, Telangana, India
2Centre for Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, 500072, Telangana, India
3Faculty of Technology, Osmania University, Hyderabad, 500007, Telangana, India
4Natco Research Centre, Natco Pharma Ltd, B-13, Industrial Estate, Sanath Nagar, Hyderabad, 500018, Telangana, India
*Corresponding Author

Published In:   Volume - 8,      Issue - 1,     Year - 2015


ABSTRACT:
Three series of thiazolidine-2,4-dione analogues (1-17, 14a-h, 15a-h, 16a-h, 17a-h) were synthesized by Knoevenagel condensation/N-alkylation/combination of both the reactions. The structure of the compounds was established based on IR, 1H NMR and Mass spectral data analysis. In the in vitro antioxidant potential evaluation, the compound 14g bearing 4-hydroxyl,3-methoxyl substitution on 5-aryl functionality shown significant reducing power (IC50 22.7±0.43 µM). Descriptor-based QSAR analysis was utilized to study the structural contribution to the radical scavenging potential. Among various QSAR models, model 12 was found to be best and the R2 value 0.858 is indicative of good correlation between in vitro and in silico activity. The QSAR studies revealed the potential contribution of the descriptors HOMO, HBD, DM and SASA towards the antioxidant activity.


Cite this article:
Swathi N, Subrahmanyam CVS, Satyanarayana K. Synthesis and Quantitative Structure-Antioxidant Activity Relationship Analysis of Thiazolidine-2,4-dione Analogues. Asian J. Research Chem 8(1): January 2015; Page 21-26. doi: 10.5958/0974-4150.2015.00005.X

Cite(Electronic):
Swathi N, Subrahmanyam CVS, Satyanarayana K. Synthesis and Quantitative Structure-Antioxidant Activity Relationship Analysis of Thiazolidine-2,4-dione Analogues. Asian J. Research Chem 8(1): January 2015; Page 21-26. doi: 10.5958/0974-4150.2015.00005.X   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2015-8-1-5


Recomonded Articles:

Author(s): Shashikant P. Pawar, Tryambakrao J. Patil, Ratnamala S. Bendre

DOI: 10.5958/0974-4150.2018.00003.2         Access: Open Access Read More

Author(s): Sonu Jacob, Anil John J., Leena Thomas, Sabulal B.

DOI:         Access: Open Access Read More

Author(s): Suman Kumari, Vinita Gupta, Sanchita Singh3, Y.K. Gupta

DOI: 10.5958/0974-4150.2018.00153.0         Access: Open Access Read More

Author(s): Deepti Dongarwar Inamdar, Afeez M Dinakaran, Vadiraj D Kurdekar, Hemant R Jadhav

DOI:         Access: Open Access Read More

Author(s): S. J. Daharwal, S Prakash Rao, Vijay Kumar Singh, Chandraprakash Dwivedi, Veena D. Singh

DOI: 10.5958/0974-4150.2015.00070.X         Access: Open Access Read More

Author(s): Nikhat F, D.Satynarayana, Subhramanyam EVS

DOI:         Access: Open Access Read More

Author(s): Shyam R. Annapure, Rahul A. Waghmare, Shantilal D. Rathod, Narayan P. Adlinge

DOI: 10.5958/0974-4150.2017.00089.X         Access: Open Access Read More

Author(s): Amar Djemoui, Djamila Djemoui, Lahcene Souli, Ahmed Souadia, Messaoud Gouamid

DOI: 10.52711/0974-4150.2021.00032         Access: Open Access Read More

Author(s): Sudhanshu Dhar Dwivedi, Arpan Bharadwaj, Amit Shrivastava

DOI:         Access: Open Access Read More

Author(s): Ganatra S. H., Patle M. R, Bhagat G. K.

DOI:         Access: Open Access Read More

Author(s): Pawan Bajpai, Shelesh Jain, Ankur Choubey

DOI: 10.5958/0974-4150.2020.00055.3         Access: Open Access Read More

Author(s): T. Sharanya Nair, Meghana R, Shlini P

DOI: 10.5958/0974-4150.2019.00037.3 9         Access: Open Access Read More

Author(s): Suresh Rajput, Dharamveer Sisodia, Hemant Badwaik, Deepa Thakur, Kushagra Nagori

DOI:         Access: Open Access Read More

Author(s): Nikhat F., Satyanarayana D., Purohit M.G., Bharat, Moid A.

DOI:         Access: Open Access Read More

Author(s): Jiby Elias, Rajesh M.G., Anish N.P., Manu M.S., Iwin C. Varkey

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags