Colostrum is the first fluid yielded from the mammary glands of mammals after parturition and is intended for ingestion by the newborn during the first hours of life. It is a complex biological fluid, contains immune and growth factors which helps in the development of immunity in the newborn. It contains Immunoglobulin’s that act as natural anti-microbial agents to actively stimulate the maturation of an infant’s immune system. It is used for treatment of many GIT diseases, Respiratory diseases, Cardiovascular and Metabolic disorders. Colostrum shows great beneficial effect as immunomodulator and anticancer agent. As antiviral agent there is a great scope in colostrum supplements. In this article, the current understanding of the composition of colostrum, i.e. carbohydrates, proteins, growth factors, enzymes, enzyme inhibitors, nucleotides and nucleosides, cytokines, fats, vitamins and minerals, is reviewed. Besides providing immune support, colostrum has remarkable muscular-skeletal repair and growth capabilities. These growth factors have significant muscle and cartilage repair characteristics. They promote wound healing with practical implications for trauma and surgical patients. Colostrum growth factors have multiple regenerative effects that extend to all structural body cells, such as the gut. Colostrum also provides immunological balance, increases energy and reduces inflammation and illness.
Cite this article:
Vipul Singh, Sanjay Kumar Kushwaha. Colostrum: A New Golden Era in Health and Disease. Asian Journal of Research in Chemistry. 2021; 14(3):208-6. doi: 10.52711/0974-4150.2021.00037
Vipul Singh, Sanjay Kumar Kushwaha. Colostrum: A New Golden Era in Health and Disease. Asian Journal of Research in Chemistry. 2021; 14(3):208-6. doi: 10.52711/0974-4150.2021.00037 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2021-14-3-9
1. Jolly A, et al. Evaluation of Hyaluronic Acid in Cattle: Physiological Variations Related to Age, Periparturition and in Clinical Cases of Paratuberculosis. J Vet Sci Technol. 2016; 7:342.
2. Offer Erez and Moshe Mazor. The Role of Late Amniocentesis in the Management of Preterm Parturition. J Women's Health Care. 2013; 2: 109.
3. Gopal PK and Gill HS. Oligosaccharides and glycoconjugates in bovine milk and colostrums. Br. J. Nutr. 2000; 84: 69-74.
4. Hyrslova I, et al. Goat and Bovine Colostrum as a Basis for New Probiotic Functional Foods and Dietary supplements. J Microb Biochem Technol. 2016; 8: 056-059.
5. Shimo SP, et al. The Influence of Heat Treatment in Liquid Whey at Various pH on Immunoglobulin G and Lactoferrin from Yak and Cows Colostrum/Milk. J Food Process Technol. 2015; 6:503.
6. Bakrrington JM, et al. Regulation of colostrogenesis in cattle. Livest. Prod. Sci. 2001; 70: 95-104.
7. Elmarsafy A, et al. Detection of Complications Following Intravenous Immunoglobulins Infusion in a Cohort of Egyptian Children. J Clin Cell Immunol. 2015; 6:321.
8. Maravic-Stojkovic V, et al. Experience with IgM-Enriched Immunoglobulins as Adjuvant Therapy in Septic Patient after Redo Cardiac Surgery. J Clin Exp Cardiolog.2015; 6: 63.
9. Lee G. Cancerous Immunoglobulins in Cancer Immunology. J Clin Cell Immunol.2014; 5: 79.
10. Justiz Vaillant AA, et al. Bacterial Proteins and Their Proposed Interactions with Fc or Fab Fragments of Immunoglobulins. Biochem Physiol. 2014; 3:43.
11. Stelwagen K, et al. Immune components of bovine colostrum and milk. Journal of animal science. 2009; 8: 7-13.
12. Uruakpa FO, Ismond MA, Akobundu EN. Colostrum and its benefits: a review. Nutrition Research. 2002 Jun 1; 22 (6): 755-67.
13. Saalfeld MH, Pereira DI, Valente JD, Borchardt JL, Weissheimer CF, Gularte MA, Leite FP. Effect of anaerobic bovine colostrum fermentation on bacteria growth inhibition. Ciência Rural. 2016; 46(12): 2152-57.
14. Ramezanalizadeh F, Aliasghari A, Khorasgani MR, Khoroushi M, Tahmourethpour A, Jabbari AR. Evaluation of hyperimmune colostrum production in bovine against cariogenic streptococci and its impact on growth and bacterial biofilm formation. Journal of Dental Medicine. 2017; 29 (4): 237-46.
15. Legrand D, Mazurier J. A critical review of the roles of host lactoferrin in immunity. Biometals. 2010 Jun 1; 23 (3): 365-76.
16. Mero A, Kahkonen J, Nykanen T, et al. IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training. J Appl Physiol. 2002; 93: 732–39.
17. Marchbank T, Davison G, Oakes JR, et al. The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. Am J Physiol Gastrointest Liver Physiol. 2011; 300 : G477–G484.
18. Davison G, Diment BC. Bovine colostrum supplementation attenuates the decrease of salivary lysozyme and enhances the recovery of neutrophil function after prolonged exercise. Br J Nutr. 2010; 103:1425–32.
19. Crooks CV, Wall CR, Cross ML, et al. The effect of bovine colostrum supplementation on salivary IgA in distance runners. Int J Sport Nutr Exerc Metab. 2006; 16:47–64.
20. Crooks C, Cross ML, Wall C, et al. Effect of bovine colostrum supplementation on respiratory tract mucosal defenses in swimmers. Int. J Sport Nutr Exerc Metab. 2010; 20:224–35.
21. Tian, X.; Li, C.; Huang, A.; Xia, S.; Lu, S.; Shi, Z.; Lu, L.; Jiang, S.; Yang, Z.; Wu, Y.; et al. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerg. Microbes Infect. 2020; 9: 382–85.
22. Lu, R.; Zhao, X.; Li, J.; Niu, P.; Yang, B.; Wu, H.; Wang, W.; Song, H.; Huang, B.; Zhu, N.; et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet. 2020; 395: 565–74.
23. Li, H.; Zhou, Y.; Zhang, M.; Wang, H.; Zhao, Q.; Liu, J. Updated Approaches against SARS-CoV-2. Antimicrob. Agents Chemother. 2020; 64.
24. Bolke E, Jehle PM, Hausmann F et al. Preoperative oral application of immunoglobulin-enriched colostrum milk and mediator response during abdominal surgery. 2002; 17: 9-12.
25. Steele J, Sponseller J, Schmidt D, et al. Hyperimmune bovine colostrum for treatment of GI infections. Hum Vaccin Immunother. 2013; 9: 1565–68.
26. Suresh A.S., Pawar Bhavna. A Study of Factors of Lifestyle and its impact on Nutraceutical Consumption: India Perspective. Asian Journal of Management. 2018; 9(1):203-11.
27. Lokhande Sarika S. Role of Nutraceuticals in Various Diseases: A Comprehensive Review. Asian J. Pharm. Res. 2018; 8(4): 236-40.
28. Patıroglu T, Kondolot M. The effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiency. Clin Respir J. 2013; 7:21–26.
29. Wyplosz, B et al. Correlation between Chlamydia pneumoniae Detection from Coronary Angioplasty Balloons and Atherosclerosis Severity, Journal of the American College of Cardiology. 2006; 470:1229–31.
30. Thakur Seema, Srivastava Neha. Nutraceuticals: A Review. Asian J. Res. Pharm. Sci. 2016; 6(2): 85-94.
31. Frystyk J, Ledet T, Moller N, Flyvbjerg A, Orskov H. Cardiovascular disease and insulin-like growth factor I. Circulation, 2002; (8):893–95.
32. Rathe M, Müller K, Sangild PT, et al. Clinical applications of bovine colostrum therapy: a systematic review. Nutr Rev 2014; 72:237–54.
33. Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002; 347:911–20.
34. Keech A. Novel immunologically active peptide fragments of a proline-rich polypeptide isolated from colostral mammalian fluids for treatment of viral and non-viral diseases or diseased conditions. US 20070212367 A1 2007.
35. Rathe M, Muller K, Sangild PT, Husby S. Clinical applications of bovine colostrum therapy: a systematic review. Nutr Rev 2014; 72: 237–54.
36. Kramski M, Center RJ, Wheatley AK, Jacobson JC, Alexander MR, Rawlin G, et al. Hyperimmune bovine colostrum as a low-cost, large-scale source of antibodies with broad neutralizing activity for HIV-1 envelope with potential use in microbicides. Antimicrob Agents Chemother. 2012; 56: 4310–19.
37. Shinde Namdeo, Bangar Bhaskar, Deshmukh Sunil, Kumbhar Pratik. Nutraceuticals: A Review on current status Research J. Pharm. and Tech. 7(1): Jan. 2014; Page 110-113.
38. Nitsch A, Nitsch FP. The clinical use of bovine colostrum. J Orthomol Med 1998; 13: 110–18.
39. Singh Vipul, Mahaur Sangeeta, Kushwaha Sanjay Kumar. Nutraceuticals: A New Golden Era in Health and Disease. Asian J. Research Chem. 2018; 11(3): 652-65.
40. Mohanty Sangeeta, Pal Abhisek, Sudam Chandra Sudam. Flavonoid as Nutraceuticals: A Therapeutic approach to Rheumatoid Arthritis. Research J. Pharm. and Tech 2020; 13(2):991-98.
41. Sura Narendra Kumar, Hiremath Lingayya. Hydroxycitric Acid (Hca)-A Potent Nutraceuticals. Research J. Pharm. and Tech. 2019; 12(7):3163-3168.
42. The Associated Press and Reuters, Clinton earmarks $50 million for Alzheimer's research. http://www.cnn.comI2000IHEALTHI07116Ialzheimers.disease.
43. Bele Archana A., khale Anubha. An approach to a Nutraceutical Research J. Pharms and Tech. 2013; 6(10): 1161-64
44. Song, M., Garrett, W. S. and Chan, A. T. Nutrients, foods, and colorectal cancer prevention. Gastroenterology. 2015; 148: 1244–60.
45. Kuipers, E. J., Rösch, T. and Bretthauer, M. Colorectal cancer screening — optimizing current strategies and new directions. Nat. Rev. Clin. Oncol.2013; 10: 130–42.
46. Papamichael, D. et al. Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013. Ann. Oncol.2014; 26: 463–76.
47. Baumrucker CR and Bruckmaier RM. 2014. Colostrogenesis: IgG1 transcytosis mechanisms. Journal of Mammary Gland Biology and Neoplasia. 19(1): 103-17.
48. Weaver DM, Tyler JW, Van Metre DC and Barrington GM. Passive transfer of colostral immunoglobulins in calves. Journal of Veterinary Internal Medicine. 2000; 14: 569-77.
49. Gajbhiye Vishal, Lahane Vishal. Nutraceutical lead to the new Era of Medicine and Health: Review Article. Res. J. Pharma. Dosage Forms and Tech.2019; 11(1): 39-42. Rebello Norma, Bhalerao Suhasini.
50. Formulation development of a Nutaceutical product comprising Manikara zapota fruit pulp. Res j. Pharm. Dosage Form. And Tech. 2016; 8(4): 255-60.
51. Jahantigh M, Atyabi N, Pourkabir M, Jebelli Javan A, Afshari M. The effect of dietary bovine colostrum supplementation on serum malondialdehyde levels and antioxidant activity in alloxan-induced diabetic rats. Int J Vet Res. 2011; 5: 63–67.
52. Pan D, Liu H. Preventive effect of ordinary and hyper-immune bovine colostrums on mice diabetes induced by alloxan. Afr J Biotechnol. 2008; 7: 4369–75.