ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): G. Muhubhupathi, M. Selvakumar, K. Mohanapriya, V. Amoga, KS. Aruna, S. Dhivya Priya, B. Dharshini Devi

Email(s): Email ID Not Available

DOI: 10.52711/0974-4150.2025.00013   

Address: G. Muhubhupathi*, M. Selvakumar, K. Mohanapriya, V. Amoga, KS. Aruna, S. Dhivya Priya, B. Dharshini Devi
*Department of Pharmaceutical Chemistry, Vivekanandha Pharmacy College for Women, Sankari, Salem - 637303. Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 18,      Issue - 2,     Year - 2025


ABSTRACT:
One of the many issues facing modern pharmaceutical chemistry is the requirement for any therapeutic agent to have both potency and specificity. Due to the widespread usage of benzenoid and hetero aromatic ring systems in intellectual property as well as the more stringent low toxicity standards seen in all patients treated moving to novel and/or typical ring systems (scaffolds) that fall outside the purview of (hetero) aromatic systems is becoming more and more common as a solution to these problems. By providing mechanistic insights of the given typical scaffolds, primarily derived from the literature of the last five years, this critical review investigates the biological activities of oxazolidine derivatives, such as anticancer, antimicrobial, antibacterial, antioxidant and anticonvulsant properties, which have found application in contemporary bio-organic chemistry and medicinal chemistry.


Cite this article:
G. Muhubhupathi, M. Selvakumar, K. Mohanapriya, V. Amoga, KS. Aruna, S. Dhivya Priya, B. Dharshini Devi. Therapeutic Potential of Oxazolidine Derivative: A Critical Review of Their Biological Activities. Asian Journal of Research in Chemistry.2025; 18(2):81-6. doi: 10.52711/0974-4150.2025.00013

Cite(Electronic):
G. Muhubhupathi, M. Selvakumar, K. Mohanapriya, V. Amoga, KS. Aruna, S. Dhivya Priya, B. Dharshini Devi. Therapeutic Potential of Oxazolidine Derivative: A Critical Review of Their Biological Activities. Asian Journal of Research in Chemistry.2025; 18(2):81-6. doi: 10.52711/0974-4150.2025.00013   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2025-18-2-4


REFERENCES:
1.    Wang X, Jin B, Han Y, Wang T, Sheng Z, Tao Y, Yang H. Optimization and Antibacterial Evaluation of Novel 3-(5- Fluoropyridine-3-yl)-2-oxazolidinone Derivatives Containing a Pyrimidine Substituted Piperazine. Molecules. 2023; 28: 4267.
2.    Foti C, Piperno A, Scala A, Giuffrè O. Oxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects. Molecules,2021;26: 4280.
3.    Campos JF, Pereira MC, de Sena WLB, de Barros Martins CG, de Oliveira JF, da Cruz Amorim CA, de Melo Rêgo MJB, da Rocha Pitta MG, de Lima MCA, da Rocha Pitta MG, da Rocha Pitta I. Synthesis and in vitro anticancer activity of new 2-thioxo-oxazolidin-4-one derivatives. Pharmacol.Rep.2017;69(4): 633-641.
4.    Fernandes GFS, Scarim CB, Kim SH, Wu J, Castagnolo D. Oxazolidinones as versatile scaffolds in medicinal chemistry.RSC Med. Chem.2023;14: 823.
5.    Liu P, Jiang Y, Jiao L, Luo Y, Wang X, Yang T. Strategies for the discovery of oxazolidinone antibacterial agents: Development and future perspectives. J. Med. Chem. 2023;66 (20): 13860-13873.
6.    Xia J, Li Y, He C, Yong C, Wang L, Fu H. Synthesis and Biological Activities of Oxazolidinone Pleuromutilin Derivatives as a Potent Anti-MRSA Agent. ACS Infect.Dis. 2023; 9(9):1711-1729.
7.    Mansouri R, Bouzina A, Sekiou O, Aouf Z, Zerrouki R. Novel pseudonucleosides and sulfamoyl-oxazolidinone β - D -glucosamine derivative as anti-COVID-19: design, synthesis, and in silico study. J. Biomol.struct.dyn. 2023;41(20): 10999-11016.
8.    Jin B, Wang T, Chen J, Liu X, Zhang Y, Zhang X, Sheng Z, Yang H. Synthesis and Biological Evaluation of 3-(Pyridine-3- yl)-2-Oxazolidinone Derivatives as Antibacterial Agents. Front. Chem.2022; 10: 949813.
9.    Alminderej F, Ghannay S, Elsamani MO, Alhawday F, Albadri AEAE, Elbehairi SEI, Alfaifi MY, Kadri A, Aouadi K. In Vitro and In Silico Evaluation of Antiproliferative Activity of New Isoxazolidine Derivatives Targeting EGFR: Design, Synthesis, Cell Cycle Analysis, and Apoptotic Inducers. Pharmaceuticals .2023; 16: 1025.
10.    Wang X, Pang F, Huang L, Yang X, Ma X, Jiang C, Li F, Lei F. Synthesis and Biological Evaluation of Novel Dehydroabietic Acid-Oxazolidinone Hybrids for Antitumor Properties. Int. J. Mol. Sci. 2018; 19: 3116.
11.    Ramalho EAVF, Viana DCF. Synthesis, Assessment of Antineoplastic Activity, and Molecular Docking of Novel 2-Thioxo-oxazolidin-4-one Derivatives. Med.chem.2022;18(9):980-989.
12.    Ampomah Wireko M, Chen S, Li R, Gao C, Wang M, Qu Y, Kong H, Nininahazwe L, Zhang E. Recent advances in the exploration of oxazolidinone scaffolds from compound development to antibacterial agents and other bioactivities. Eur. J. Med.Che.2024; 269: 0223-5234.
13.    Xia J, Li Y, He C, Yong C, Wang L, Fu H, He XL, Wang ZY, Liu DF, Zhang YY. Synthesis and biological activities of oxazolidinone pleuromutilin derivatives as a potent anti-MRSA agent. ACS Infectious Diseases 2023; 9 (9): 1711-1729.
14.    Liu Y, Esser l, Bai H, Fu B, Xia D, Zhou Y, Hong S, Yang S, Xiao Y, Qin Z. Synthesis and antiphytopathogenic activity of novel oxazolidine-2,4-diones bearing phenoxypyridine moiety. J. Agrl. Food Chem. 2023; 71 (39): 14199-14210.
15.    Leer Y, Rong S, Mengying G, Yuan W, Siyuan C. Biologically Active 2-Oxazolidinone Derivatives Beyond Antibacterial Activities. Curr.med. chem.2023; 30(23): 2672-2689.
16.    Buckley ME, Ndukwe ARN, Nair PC, Rana S, Fairfull-Smith KE, Gandhi NS. Comparative Assessment of Docking Programs for Docking and Virtual Screening of Ribosomal Oxazolidinone Antibacterial Agents. Antibiotics. 2023; 12(3): 463.
17.    Eneama WA, Salmnan HH. Isoxazolidine Derivatives Exhibit Selective Antitumor Activity Against Breast Cancer Cells. acopen.umsida.ac.id, 2024; 9(2).
18.    Armentano B, Curcio R, Brindisi M, Mancuso R, Rago V, Ziccarelli I, Frattaruolo L, Fiorillo M, Dolce V, Gabriele B, Cappello AR. 5-(Carbamoylmethylene)-oxazolidin-2-ones as a Promising Class of Heterocycles Inducing Apoptosis Triggered by Increased ROS Levels and Mitochondrial Dysfunction in Breast and Cervical Cancer. Biomedicines 2020; 8(2): 35.
19.    You X, Hu KW, Zong H, Wen X, Yuan H, Cheng K, Xu QL, Lai Z. Synthesis of Polycyclic Fused Oxazolidin-2-Ones by Catalytic Boron (Iii)-Promoted Oxo-Michael Addition Reaction and Evaluation on Their Cytotoxicity. Adv. J. Chem. A 2024; 7 (6): 894-909.
20.    Qabel HA, Majidi SMH AI. Synthesis and identification of some new Imidazolidine-4-one, Oxazolidine-4-one, and Thiazolidine-4-one derivatives from phenidone and their antimicrobial and antioxidant. Adv. J. Chem. A 2024; 7 (6): 894-909.
21.    Patekar M, Mali A, Kalawade K, Jadhav G, Deshmukh D, Medhane V. Synthesis and Evaluation of Novel (5S)-5- (Aminomethyl)-3-[4-(6,7-Dihydrothieno[3,2-c] Pyridin-5(4H)-yl) Phenyl]-1,3-Oxazolidin-2- One Derivatives as Potent Antimicrobial Agents. Polycycl.Aromat.Compd. 2023; 43(7): 6470-6483.
22.    Pendem O, Dr. Podila NK. Synthesis and antimicrobial evaluation of new derivatives of 5- (((2-chloroquinoxalin-3-yl) amino) methyl)-3-(3,4- substitutedphenyl) oxazolidin-2-ones. IOSR. J.Appl.chem, 2019;12(8): 2278-5736.
23.    Jin B, Chen J, Sheng, Z, Sun M, Yang H. Synthesis, Antibacterial and Anthelmintic Activity of Novel 3-(3-Pyridyl)- oxazolidinone-5-methyl Ester Derivatives. Molecules. 2022; 27: 1103.
24.    Patekar MR, Medhane VJ, Jadhav GJ, Thakare MJ, Deshmukh DG. Synthesis of (s)-1-{3-[4-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-yl-metyl}-3-substituted-urea derivatives as antibacterial. J.Heterocycl.Chem.2021;58(11): 2152-2162.
25.    Muslim RF, Majeed IY, Saleh SE, Saleh MM, Owaid MN, Abbas JA. Preparation, Characterization and Antibacterial Activity of some New Oxazolidin-5-one Derivatives Derived from Imine Compounds. J.chem.Health Risk. 2022; 12(4).
26.    Jiang J, Hou Y, Duan M, Wang B, Wu Y, Ding X, Zhao Y. Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety. Bioorg.Med. Chem. Lett. 2021; 32: 127660.
27.    Wasan K Damdoom, Oday HR Al-Jeelani. Synthesis and Characterization of Some Oxazolidine and Thiazolidine Derivatives and Study of their Antioxidants Activity. Iraq. J. Sci. 2024; 65(11): 6242- 6252.
28.    Al-Tannak NF, Phillips OA, Kamal HJ, Hemdan A. Development and Validation of Stability-Indicating Assay Method for a Novel Oxazolidinone (PH-192) with Anticonvulsant Activity by Using UHPLC-QToF-MS. Molecules. 2022; 27:1090.

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