ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rushikesh Kishor Sonawane, Karishma Ravindra Nere, Shrinivas Krishna Mohite

Email(s): rushikesh.sonawane509@gmail.com

DOI: 10.52711/0974-4150.2022.00052   

Address: Rushikesh Kishor Sonawane*, Karishma Ravindra Nere, Shrinivas Krishna Mohite
Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India - 415404.
*Corresponding Author

Published In:   Volume - 15,      Issue - 4,     Year - 2022


ABSTRACT:
There has been considerable interest in the development of novel compounds with anticonvulsant, analgesic, anti-inflammatory, antimicrobial, antimycobecterial, antitumour, and antitubercular activities. 1,3,4-thiadiazole constitute an important class of compound for new drug development. They have interesting pharmacophore that display a broad spectrum of Pharmacological activity. The 1,3,4-thiadiazole compound is an interesting heterocycling group that has been used to synthesize a variety of useful bioactive compounds. The stability of thiadiazole nucleus has inspired medicinal chemist to carry out various structural variation in the ring. The marketed drugs such as acetazolamide and methazolamide etc showed their therapeutic potential Therefore; many researchers have synthesized these compounds as target structures and evaluated their biological activities. This review highlights the various Pharmacological activities associated with 1,3,4-thiadiazole ring system.


Cite this article:
Rushikesh Kishor Sonawane, Karishma Ravindra Nere, Shrinivas Krishna Mohite. Heterocyclic system containing bridgehead nitrogen atom: Substituted 1,2,3-Triazolo [3,4-b]-1,3,4-Thiadiazole derivative useful for the treatment of breast cancer and other diseases. Asian Journal of Research in Chemistry. 2022; 15(4):295-8. doi: 10.52711/0974-4150.2022.00052

Cite(Electronic):
Rushikesh Kishor Sonawane, Karishma Ravindra Nere, Shrinivas Krishna Mohite. Heterocyclic system containing bridgehead nitrogen atom: Substituted 1,2,3-Triazolo [3,4-b]-1,3,4-Thiadiazole derivative useful for the treatment of breast cancer and other diseases. Asian Journal of Research in Chemistry. 2022; 15(4):295-8. doi: 10.52711/0974-4150.2022.00052   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2022-15-4-9


REFERENCES:
1.    Gabe K, Five-membered Rings with More than Two Heteroatoms and Fused Carbocyclic Derivatives, Comprehensive Heterocyclic Chemistry II, 1996.
2.    Raj V, Rai A, Singh M, Kumar A, Kumar V, Sharma SK, Recent update on 1, 3, 4-thiadiazole derivatives: as anticonvulsant agents, EC Pharmaceutical Science, 2015;2(1):202-209.
3.    Subbaiah NY, Mohanty SK, Sudha BN, Ayyanna C, Synthesis, characterization and evaluation of antibacterial & anti-fungal activity of 2, 5-disubstituted 1, 3, 4- oxadiazole derivatives, International Journal of Research in Pharmacy and Pharmaceutical Sciences, 2016;1(2):39-42.
4.    Patel MB, Modi NR, Raval JP, Menon SK, Calix [4] arene based 1, 3, 4-oxadiazole and thiadiazole derivatives: Design, synthesis, and biological evaluation, Organic & Biomolecular Chemistry, 2012;10(9):1785-94.
5.    Shridhar AH, Keshavayya J, Peethambar SK, Hoskeri HJ, Synthesis and biological activities of Bis alkyl 1, 3, 4-oxadiazole incorporated azo dye derivatives, Arabian Journal of Chemistry, 2016; 1(9): 1643-8.
6.    Wei Z, Jiao D, Xu J, Using Fourier transform infrared spectroscopy to study effects of magnetic field treatment on wheat (Triticum aestivum L.) seedlings, Journal of Spectroscopy, 2015;2015:1-6.
7.    Gerothanassis IP, Troganis A, Exarchou V, Barbarossou K, Nuclear magnetic resonance (NMR) spectroscopy: basic principles and phenomena, and their applications to chemistry, biology and medicine, Chemistry Education Research and Practice, 2002;3(2): 229-52.
8.    Bartosova A, Blinova L, Gerulova K, Characterisation of polysacharides and lipids from selected green algae species by FTIR-ATR spectroscopy, Res. Pap. Fac. Mater. Sci. Technol. Slovak Univ. Technol, 2015;23(36): 97-102.
9.    Chen YW, Clore GM, A systematic case study on using NMR models for molecular replacement: p53 tetramerization domain revisited, international union of Crystallography, 2000; 56(12): 1535-40.
10.    Girish V, Rekha N.D, Lakshmi Ranganatha V, Manjula S.N, Shaukhat Ara Khanum, Synthesis and evaluation of antiangiogenic and anticancer properties of novel oxadaizole analogue, International Research Journal of Pharmacy,2014:5(6): 489-494.
11.    Suja Gunasekaran, Vinoth Kumar Thirumalairaj, Lakshmana Senthil Shanmugasokan, Suganya Pitchai, Rincy Yesudas, Amrutha Chacko,Screening of in vitro cytotoxic activity of brown seaweeds against hepatocellular carcinoma, Journal of Applied Pharmaceutical Science. 2017;7(05): 051-055.
12.    Vinayak Adimule, Sudha Medapa, Adarsha Haraballi Jagadeesha, Lalita Sanjeev Kumar, Prakash Kumar Rao, Synthesis, characterization and cytotoxic evaluation of novel derivatives of 1, 3, 4-oxadiazole containing 5-phenyl thiophene moiety, IOSR Journal of Pharmacy and Biological Sciences. 2014;9(5):42-48.
13.    Raju Asirvatham, Arockiasamy Josphin Maria Christina, Anita Murali, In Vitro Antioxidant and Anticancer Activity Studies on Drosera Indica L. (Droseraceae), Advanced Pharmaceutical Bulletin. 2013;3(1):115-120.
14.    A. Krishna Veni, S. Mohandass, In-vitro Cytotoxic Activity of Enicostemma axillare Extract against Hela Cell Line, International Journal of Pharmacognosy and Phytochemical Research. 2014; 6(2): 320-323.
15.    Ma Cristina De Las Llagas, Librado Santiago, John Donnie Ramos, Cytotoxicity and Apoptotic Activity of Ficus pseudopalma Blanco Leaf Extracts against Human Prostate Cancer Cell Lines, Tropical Journal of Pharmaceutical Research. 2014;13(1):93-100.
16.    Vinayak Adimule, Sudha Medapa, Lalita S Kumar, Prakash Kumar Rao, Novel Substituted Phenoxy Derivatives of 2-Chloro-N-{5-[2-(4-Methoxy-Phenyl)-Pyridin-3-yl]-[1,3,4] Thiadiazol-2-yl}-Acetamides: Synthesis, Characterization and in vitro Anticancer Properties. Journal of Pharmaceutical, Chemical and Biological Sciences. 2014;2(2):188-195.

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