Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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An improved synthesis of finasteride from 4-androsten-3,17-dione

Author(s): Nguyen Hai Nam, Ngo Anh Ngoc

Email(s): nhnam@hotmail.com

DOI: Not Available

Address: Nguyen Hai Nam* and Ngo Anh Ngoc
Department of Pharmaceutical Chemistry and Center for New Drugs Discovery and Development (C3D), Hanoi University of Pharmacy 13-15 Le Thanh Tong, Hoan Kiem District, Hanoi, Vietnam
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010

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ABSTRACT:
An improved synthesis of 3-oxo-4-aza-5a-androst-1-ene-17ß-(N-tert-butylcarboxamide), commonly known as finasteride (1), a drug widely used for the treatment of benign prostatic hyperplasia (BPH), has been implemented via seven steps in an overall yield of 20.01% starting from 4-androsten-3,17-dione (AD). Conditions of several steps have been improved to be less expensive and more commercially viable compared to reported synthesis in literature.


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Cite this article:
Nguyen Hai Nam, Ngo Anh Ngoc. An improved synthesis of finasteride from 4-androsten-3,17-dione. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1099-1102.

Cite(Electronic):
Nguyen Hai Nam, Ngo Anh Ngoc. An improved synthesis of finasteride from 4-androsten-3,17-dione. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1099-1102.   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2010-3-4-69


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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