ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Syeda Kulsum, Sravani A., M. Kanaka Durga, T. Snehalatha, Thimmareddy D.

Email(s): alamsravani@gmail.com

DOI: Not Available

Address: Syeda Kulsum, Sravani A.*, M. Kanaka Durga, T. Snehalatha, Thimmareddy D.
Department of Pharmaceutical Analysis and Quality Assurance, Vijaya College of Pharmacy, Munaganoor, Hayathnagar, Hyderabad
Corresponding Author

Published In:   Volume - 5,      Issue - 9,     Year - 2012


ABSTRACT:
A simple, rapid, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of Cefpodoxime proxetil and Ofloxacin Bulk and Tablet dosage form. An Thermo hypersil C18, 5 µ column having 150 x 4.6mm id in Isocratic mode with mobile phase containing 0.1M Dipotassium Hydrogen Phosphate Buffer : methanol (90:10 %v/v pH: 6.0 adjusted with Ortho phosphoric acid) was used. The flow rate was 1ml/min and effluents were monitored at 265nm. The retention time of Cefpodoxime proxetil and Ofloxacin was 6.9min and 9.0min respectively. The concentration curves were linear in the concentration range of 200-600µg/mL and 200-600 µg/mL. The developed method was validated for specificity, precision, linearity, accuracy, LOD, LOQ, robustness. Recovery of Cefpodoxime proxetil and Ofloxacin in formulations was found to be in the range of 98% -102% and 98%-102% respectively confirms the non-interferences of the excipients in the formulation. Due to its simplicity, rapidness and good precision, the proposed HPLC method may be used for the simultaneous determination of these two drugs in pharmaceutical dosage forms.


Cite this article:
Syeda Kulsum, Sravani A., M. Kanaka Durga, T. Snehalatha, Thimmareddy D.. A New Validated RP-HPLC Method for the Simultaneous Estimation of Cefpodoxime Proxetil and Ofloxacin in Bulk and Pharmaceutical Dosage Forms. Asian J. Research Chem. 5(9): September, 2012; Page 1166-1171.

Cite(Electronic):
Syeda Kulsum, Sravani A., M. Kanaka Durga, T. Snehalatha, Thimmareddy D.. A New Validated RP-HPLC Method for the Simultaneous Estimation of Cefpodoxime Proxetil and Ofloxacin in Bulk and Pharmaceutical Dosage Forms. Asian J. Research Chem. 5(9): September, 2012; Page 1166-1171.   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2012-5-9-14


Recomonded Articles:

Author(s): Ravi N. Patel, Urviben Y. Patel, Kiran M. Patel, Jimit S. Patel, Ankit D. Patel, Dhrubo Jyoti Sen

DOI:         Access: Open Access Read More

Author(s): Chavan Pooja Ajit, Avinash Mahadeo Bhagwat, Atul Prabhakar Chaudhari

DOI: 10.52711/0974-4150.2021.00061         Access: Open Access Read More

Author(s): Mukund Nagarnaik, Arun Sarjoshi, Ajay Bodkhe, Bhupendra Khanal, Mayuri Pise, Girish Pandya

DOI: 10.5958/0974-4150.2015.00102.9         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Nirav C. Patel, Dipti B. Patel, Pruthviraj K. Chaudhari

DOI:         Access: Open Access Read More

Author(s): Prasanna Reddy Battu, MS Reddy

DOI:         Access: Open Access Read More

Author(s): Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy

DOI: 10.5958/0974-4150.2016.00076.6         Access: Open Access Read More

Author(s): Sravani A

DOI: 10.5958/0974-4150.2018.00144.X         Access: Open Access Read More

Author(s): Nachiket S. Dighe, Priyanka R. Varade, Ganesh S. Shinde, Priya S. Rao

DOI: 10.5958/0974-4150.2019.00028.2         Access: Open Access Read More

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags