Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Pharmacological Screening of Rhizome of Curcuma amada roxb. in Rodent models

Author(s): Manish Vishwakarma, Anand Chourasia

Email(s): vishvkarmamanish51@gmail.com

DOI: 10.5958/0974-4150.2020.00005.X   

Address: Manish Vishwakarma, Anand Chourasia
Millennium College of Pharmacy, Bhopal- 462001
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2020

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ABSTRACT:
This is the first report to screen scientifically an anticonvulsant effect of hydroalcoholic extract of Curcuma amada in different animal models. The results revealed that treatment with hydroalcoholic extract of Curcuma amada protected against MES and PTZ-induced convulsions and mortality, and these effects were comparable with standard anticonvulsant agents. In order to evaluate the therapeutic value of hydroalcoholic extract as anticonvulsant, we tested its influence in different animal models viz., PTZ and MES -induced seizures in Swiss albino mice. In MES induced seizure model, hydroalcoholic extract of Curcuma amada dose dependently decreased duration of hind limb extension that was comparable to that of diazepam. The mechanism by which hydroalcoholic extract of Curcuma amada produced anticonvulsant effect against MES -induced seizures is not known. We also tested the effects of hydroalcoholic extract of Curcuma amada against convulsions induced by PTZ, an agent widely reported to induce convulsion by inhibition and/or attenuation of GABA-ergic neurotransmission.


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Cite this article:
Manish Vishwakarma, Anand Chourasia .Pharmacological Screening of Rhizome of Curcuma amada roxb. in Rodent models.Asian J. Research Chem. 2020; 13(1): 19-22. doi: 10.5958/0974-4150.2020.00005.X

Cite(Electronic):
Manish Vishwakarma, Anand Chourasia .Pharmacological Screening of Rhizome of Curcuma amada roxb. in Rodent models.Asian J. Research Chem. 2020; 13(1): 19-22. doi: 10.5958/0974-4150.2020.00005.X   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2020-13-1-5


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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