Author(s):
Tariqul Islam, Nur Amin Bitu, Faruk Hossen, Ali Asraf, Kudrat-E-Zahan
Email(s):
kudrat.chem@ru.ac.bd
DOI:
10.52711/0974-4150.2024.00002 
Address:
Tariqul Islam, Nur Amin Bitu, Faruk Hossen, Ali Asraf, Kudrat-E-Zahan*
Department of Chemistry, Rajshahi University, Rajshahi - 6205, Bangladesh.
*Corresponding Author
Published In:
Volume - 17,
Issue - 1,
Year - 2024
ABSTRACT:
A Schiff base ligand was synthesized via the condensation reaction of thiosemicarbazide and salicylaldehyde. A series of transition metal complexes of VO(IV), Ni(II), Cu(II), and Zn(II) were obtained by the complexation reaction with the synthesized Schiff base ligand. The Schiff base ligand and its metal complexes were characterized by UV-Vis and FTIR spectroscopy, TGA-DTA, and some physical measurements. FTIR spectral studies showed that the NOS donor ligand coordinated to the metal ions through the N of azomethine group, S of thiolate, and O of deprotonated hydroxyl group. Molar conductance values indicated non electrolytic nature of the complexes. Magnetic moment values coupled with electronic spectral data exhibited the geometrical structure of the complexes. The Schiff base and its complexes were exposed to disinfectant studies tested by using the disc diffusion method. All the synthesized compounds exhibited moderate to strong antibacterial activity. The copper complexes showed more antibacterial activity than other complexes and Schiff bases. All the Synthesized complexes showed a good cytotoxic activity.
Cite this article:
Tariqul Islam, Nur Amin Bitu, Faruk Hossen, Ali Asraf, Kudrat-E-Zahan. Investigation on Biological Activities of Thiosemicarbazide Derived Schiff Base-Metal Complexes. Asian Journal of Research in Chemistry. 2024; 17(1):6-2. doi: 10.52711/0974-4150.2024.00002
Cite(Electronic):
Tariqul Islam, Nur Amin Bitu, Faruk Hossen, Ali Asraf, Kudrat-E-Zahan. Investigation on Biological Activities of Thiosemicarbazide Derived Schiff Base-Metal Complexes. Asian Journal of Research in Chemistry. 2024; 17(1):6-2. doi: 10.52711/0974-4150.2024.00002 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2024-17-1-2
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