ABSTRACT:
In this research work, the heterocyclic Schiff bases ligand derived from 2,6 diamino 4-hydroxy pyrimidine with P-Methoxysalicylaldehyde (L) was synthesized. The ligand used to synthesis complexes of Cu(II), Ni(II), And Mn(II). The synthesized compounds have been characterized by FT-IR, 1H-NMR and UV-Vis techniques for the ligands and FT-IR, UV-Vis, all reactions monitored by TLC, molar conductivity and magnetic susceptibility measurements for the corresponding complexes. The conductance measurements in DMSO showed that the Cu(II), Ni(II), And Mn(II) complex was 1:2 electrolytes respectively. The antifungal and antibacterial properties of the ligand and its complexes were tested against Fusarium moneliforme, Aspergillus niger, Penicillium chrysogenum and Staphylococcus aureus, Salmonella typhi, B. subtilis, Aspergillus flavus and Escherichia coli. The result indicated that the complexes exhibited good antifungal and antibacterial activities.
Cite this article:
D. T. Sakhare. Synthesis, Characterization and Biological Studies of Schiff Bases of 2,6 diamino 4-hydroxy pyrimidine with P- Methoxysalicylaldehyde and Some Transition Metal Complexes. Asian Journal of Research in Chemistry.2026; 19(3):221-7. doi: 10.52711/0974-4150.2026.00034
Cite(Electronic):
D. T. Sakhare. Synthesis, Characterization and Biological Studies of Schiff Bases of 2,6 diamino 4-hydroxy pyrimidine with P- Methoxysalicylaldehyde and Some Transition Metal Complexes. Asian Journal of Research in Chemistry.2026; 19(3):221-7. doi: 10.52711/0974-4150.2026.00034 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2026-19-3-6
REFERENCES:
1. D.T. Sakhare, Synthesis, characterization of some transition metal complexes of bidentate Schiff base and their antifungal and antimicrobial studies. Advances in Applied Science Research. 2015; 6(6): 10-16.
2. D. T. Sakhare. Synthesis, Characterization and Antimicrobial Activity of Schiff Base Derived from 2-Hydroxybenzaldehyde with 2-Amino-4,6-Dimethylpyrimidine and Their Transition Metal Complexes. GIS Science Journal, 2022; 9(4): 82-94.
3. D.T. Sakhare. Synthesis, Characterization and Antimicrobial Activities of Aminopyrimidine Schiff Base Ligand and their Complexes of Cu(II) and Mn(II). Nigerian Research Journal of Chemical Sciences. 2025; 13(1): 18-31.
4. D.T. Sakhare, Synthesis, characterization and antimicrobial activities of some Mn(II) and Fe(III) complexes of biologically active bidentate ligands. Journal of Chemical and Pharmaceutical Research. 2015; 7(6): 198-204.
5. D.T. Sakhare, Copper Metal Complexes of a Pyrimidine Based Schiff Base Ligand Synthesis, Characterization and Biological Activity. Journal of Xidian University. 2022; 16(3): 191-201.
6. D.T. Sakhare. Green Synthesis, Characterization and Biological Evaluation of Divalent Transition Metal Complexes of Substituted Aminopyrimidine Novel Schiff Base Ligand. Science Journal of Chemistry. 2025; 13(1): 1-10.
7. D.T. Sakhare. Synthesis, Characterization and Biological Studies of Aminopyrimidine Schiff Bases and Their Transition Metal Complexes, Dickensian Journal. 2022; 22(4): 65-77.
8. D.T. Sakhare. Synthesis, Characterization of Some Transition Metal Complexes of Bidentate Schiff Base and Their Antifungal and Antimicrobial Studies. Advances in Applied Science Research. 2015; 6(6): 10-16.
9. D.T. Sakhare. Synthesis, characterization and biological activities of new bidentate Schiff base ligand and their Co (II) metal complexes. 2024, Materials Today: Proceedings, online.
10. D.T. Sakhare. Synthesis, Characterization and In-Vitro Biological Activities of Novel Bidentate Schiff Base Ligand and Their Cobalt (II) Complexes. Juni Khyat. 2023; 13(7): 134-143.
11. D.T. Sakhare. Synthesis, Characterization and Antimicrobial Activity of Cu(II) Complexes Derived from Heterocyclic Schiff Bases Ligands. Asian Journal of Organic & Medicinal Chemistry. 202; 7(2): 41-47.
12. D.T. Sakhare. Synthesis, Characterization And Biological Activity of New Schiff Bases 1-(((4,6-Dimethylpyrimidin-2-Yl)Imino) Methyl)Naphthalen-2-ol And Their Fe (III) Complexes. Juni Khyat. 2024; 14,9(2): 101-111.
13. G.G. Mohamed, M.M. Umar, A.M.M. Spectrochim, Actapart A. 2005; 62: 1140.
14. D.T. Sakhare. Synthesis, Characterization and Antimicrobial Activity of Cu(II) Complexes Derived from Heterocyclic Schiff Bases Ligands. Asian Journal of Organic & Medicinal Chemistry. 2022; 7(2): 41-47.
15. N. Raman, S. Thalamuthu, J. Dhaveethuraja, M.A. Neelakandan, S.J. banerjee. Chil. Chem. Soc. 2008; 53: 21.
16. P.G. Baraldi, M.G. Pavani, N. Nunes, P. Brigidi, B. Vitali, R. Gambari, R. Romagnoli. Arch. Pharm. 2002; 10: 449.
17. D.T. Sakhare. Synthesis, Spectral, Thermal and Antimicrobial Activities of Mn (II) and Fe (III) Schiff Base Metal Complexes. International Journal of Current Research in Chemistry and Pharmaceutical Sciences. 2015; 2(7): 1-8.
18. S.M. Sondhi, M. Johar, S. Rajvanshi, S.G. Dastidar, R. Shukla, R. Raghubir, J.W. Lown. Aust. J. Chem. 2001; 54: 69.
19. D.T. Sakhare. Synthesis, Characterization of some Cu (II) complexes of bidentate Schiff base and their antimicrobial studies. Journal of Medicinal Chemistry and Drug Discovery. 2016; 2(1): 583-597.
20. G. Mangalagiu, M. Ungureanu, G. Grosu, L. Mangalagiu, M. Petrovanu. Ann. Pharm. Fr. 2001; 59: 139.
21. M. Sonmeza, M. C¸ Elebib, A. Leventb, I˙. Berberc, Z. S¸ Enturkb, J. Coord. Chem. 2010; 63: 1986.
22. D.T. Sakhare. Synthesis, Characterization and Biological Evaluation of New Aminopyrimidine Schiff Base and Its Transition Metal Complexes, International Conference Proceedings on Multidisciplinary Research on Integrating Knowledge for Sustainable Future in Global Outlook. 2024; (1): 233-246.
23. Osowole1 A A, Kempe R, Schobert R 3and Balogun S A. Candian Journal of Pure and Applied Sciences. 2010; 4(2): 1169-1178.
24. D. T. Sakhare. Syntheses, characterization of some transition metal complexes of bidentate schiff base and their antimicrobial activities. Der Chemica Sinica. 2015; 6(6): 1-6.
25. Osowole A.A and Akpan E.J. European Journal of Applied Sciences. 2012; 4(1): 14-20,
26. D.T. Sakhare. Synthesis, Characterization and Antimicrobial Studies on Schiff Base Derived From 2-Amino 4,6- Dihydroxypyrimidine and Benzaldehyde and Its Cobalt Complexes. International Journal of Food and Nutrition Science. 2022; 11(S1): 970-982.
27. V. Singh and U. Singh. Synthesis and Spectroscopic Studies of Schiff Base and Its Divalent and Trivalent Metal Complexes. Asian Journal of Chemistry. 2013; 25(14): 8195-8198.
28. D.T. Sakhare. Synthesis, Characterization and Biological Evaluation of Schiff Base Ligand and their Fe (III) Complexes. International Journal of Advanced Science and Engineering. 2024; 11(1): 3788-3797.
29. Osowole A.A. and Yoade R. O. Scientific Journal of Applied Research. 2013; 4: 101-106
30. D.T. Sakhare. Synthesis, Characterization And Spectroscopic Study of New 3-{[(4,6-Dihydroxy Pyrimidin-2-yl) imino]methyl}Napthalen-2-ol Schiff-Base LigandAnd It’s Transition Metal Complexes. International Journal of Scientific Research in Chemical Sciences. 2024; 11(1): 3788-3797.
31. Usharani M. Akila, E. And Rajavel R. Evaluation of the pharmacological proper Co (II), Cu(II), Ni (II) and Zn(II) complexes derived from 2-((e))-4-nitrophenylimino) methyl) phenol. International Journal of Recent Scientific Research. 2013; 4(9); 1385- 1390.
32. D.T. Sakhare. Synthesis, Characterization And Antimicrobial Studies of Some Transition Metal Complexes of Schiff Bases. International Journal of Current Research In Chemistry And Pharmaceutical Sciences. 2015; 2(6): 28–34.
33. Avaji P. G., Reddy B. N. and Patil S. A. Synthesis, spectral characterization, biological and fluorescence studies of lanthanum(III) complexes with 3-substituted-4-amino-5-hydrazino-1,2,4-triazole Schiff bases. Transition Metal Chemistry. 2006; 31: 842-848.
34. Pargathi M. and Reddy K. H.,Pargathi M. and Reddy K. H. Synthesis, spectral characterization and DNA interactions of copper (II) and nickel (II) complexes with unsymmetrical Schiff base ligands. Indian Journal of Chemistry. 2013; 52A: 845-853.
35. D.T. Sakhare. Synthesis, Characterization and Biological Activity of New Schiff Bases Derived from Aminopyrimidine and Their Metal Complexes. International Journal of Scientific Research in Science and Technology. 2022; 9(17): 160-173.
36. D.T. Sakhare. Synthesis, characterization and in-vitro biological activities of Co (II) complexes of 2-(4-Methaylbenzylideneamino) Pyrimidine-4, 6-Diol., Current Pharma Research. 2019; 9(4): 3335-3344.
37. Despande V.G., Shaha S, Despande M.M., Habib S.I., Kulkarni P.A. Asian Journal of Biochemical Pharmaceutical Research. 2013; 1(3): 63-70.
38. D.T. Sakhare. Synthesis, Characterization and Antimicrobial Activity of Novel 2-Amino-4, 6- Dimethylpyrimidine and 2- Hydroxy-5- Nitrobenzaldehyde Schiff Base Ligand and Their Transition Metal Complexes. International Journal of Advance and Applied Research. 2024; 5(40): 35-44.
39. D.T. Sakhare. Synthesis, Characterization and Antimicrobial Activities of Aminopyrimidine Schiff Base Ligand and their Complexes of Cu(II) and Mn(II). Nigerian Research Journal of Chemical Sciences. 2025; 13(1): 18-31.
40. D.T. Sakhare. Synthesis, characterization and antimicrobial activities of some transition metal complexes of biologically active bidentate ligands. Inorganic Chemistry An Indian Journal.2015; 10(4): 142-147.