ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Arjun Singh

Email(s): arjunphar@gmail.com

DOI: 10.52711/0974-4150.2023.00064   

Address: Arjun Singh*
Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
*Corresponding Author

Published In:   Volume - 16,      Issue - 5,     Year - 2023


ABSTRACT:
Traditional medicine have been used for many disease ailments from the many potentials abilities, and procedures based on assumptions, beliefs, and experiences of traditional societies to preserve their health benefits. Many rural or indigenous populations in many undeveloped nations place a high importance on traditional herbal remedies. Natural products are a common medicinal source that has been used for millennia in Asia, America, and Africa to treat a variety of maladies including high blood pressure, lower cardiac arrest, colic, influenza, dysentery, dyspepsia, and malaria. It contains several photochemical compounds that have distinct and intriguing biological effects. To bridge the gap for future research prospects, this study discusses the past and present state of research on antihypertensive properties of different natural sources of plant based lignan and neolignans in terms of medicinal usage, phytochemistry, pharmacological activities Calcium based, toxicity profile, and therapeutic usage. This assessment is based on a review of the literature in scientific journals and books obtained from libraries and electronic sources. Natural therapeutic properties are just one benefit of medicinal plants; they also provide disease prevention. In this concise overview study research, we are trying to summarize, aggregate the number of plants, and identify their ethnopharmacological properties.


Cite this article:
Arjun Singh. Ethnopharmacological Overview on Natural Lignan and Neolignan for the Treatment of Cardiovascular Diseases and their Potential Pharmacological Mechanism.394-8 doi: 10.52711/0974-4150.2023.00064

Cite(Electronic):
Arjun Singh. Ethnopharmacological Overview on Natural Lignan and Neolignan for the Treatment of Cardiovascular Diseases and their Potential Pharmacological Mechanism.394-8 doi: 10.52711/0974-4150.2023.00064   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2023-16-5-14


REFERENCE:
1.    World Health Organization. WHO traditional medicine strategy: 2014-2023. World Health Organization, 2013.
2.    World Health Organization. WHO global report on traditional and complementary medicine 2019. World Health Organization, 2019.
3.    Qi, Zhang. "Who Traditional Medicine Strategy. 2014-2023." Geneva: World Health Organization 188 (2013).
4.    World Health Organization. "The regional strategy for traditional medicine in the Western Pacific (2011-2020)." (2012).
5.    World Health Organization. Regional strategy for traditional medicine in the Western Pacific. Manila: WHO Regional Office for the Western Pacific, 2002.
6.    Chanda, D., Prieto-Lloret, J., Singh, A., Iqbal, H., Yadav, P., Snetkov, V., Aaronson, P.I. Glabridin-induced vasorelaxation: Evidence for a role of BKCa channels and cyclic GMP. Life Sciences. 2016; 165: 26–34.
7.    Gautam, Y., Dwivedi, S., Srivastava, A., Hamidullah, Singh, A., Chanda, D., Singh, J., Rai, S., Konwar, R., Negi, A.S. 2-(3′,4′-Dimethoxybenzylidene)tetralone induces anti-breast cancer activity through microtubule stabilization and activation of reactive oxygen species. RSC Adv. 2016; 6: 33369–33379.
8.    Hamid, A.A., Hasanain, M., Singh, A., Bhukya, B., Omprakash, Vasudev, P.G., Sarkar, J., Chanda, D., Khan, F., Aiyelaagbe, O.O., Negi, A.S., 2014. Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin. Steroids. 2014; 87: 108–118.
9.    Hamid, A.A., Kaushal, T., Ashraf, R., Singh, A., Chand Gupta, A., Prakash, O., Sarkar, J., Chanda, D., Bawankule, D.U., Khan, F., Shanker, K., Aiyelaagbe, O.O., Negi, A.S. (22β,25R)-3β-Hydroxy-spirost-5-en-7-iminoxy-heptanoic acid exhibits anti-prostate cancer activity through caspase pathway. Steroids. 2017; 119: 43–52.
10.    Jain, S., Singh, A., Khare, P., Chanda, D., Mishra, D., Shanker, K., Karak, T., 2017. Toxicity assessment of Bacopa monnieri L. grown in biochar amended extremely acidic coal mine spoils. Ecological Engineering. 2017; 108: 211–219.
11.    Khwaja, S., Fatima, K., Hasanain, M., Behera, C., Kour, A., Singh, A., Luqman, S., Sarkar, J., Chanda, D., Shanker, K., Gupta, A.K., Mondhe, D.M., Negi, A.S. Antiproliferative efficacy of curcumin mimics through microtubule destabilization. European Journal of Medicinal Chemistry. 2018; 151: 51–61.
12.    Kumar, B.S., Ravi, K., Verma, A.K., Fatima, K., Hasanain, M., Singh, A., Sarkar, J., Luqman, S., Chanda, D., Negi, A.S. Synthesis of pharmacologically important naphthoquinones and anticancer activity of 2-benzyllawsone through DNA topoisomerase-II inhibition. Bioorganic and Medicinal Chemistry. 2017; 25: 1364–1373.
13.    Mishra, D., Jyotshna, Singh, A., Chanda, D., Shanker, K., Khare, P. Potential of di-aldehyde cellulose for sustained release of oxytetracycline: A pharmacokinetic study. International Journal of Biological Macromolecules. 2019; 136: 97–105.
14.    Sathish Kumar, B., Kumar, A., Singh, J., Hasanain, M., Singh, A., Fatima, K., Yadav, D.K., Shukla, V., Luqman, S., Khan, F., Chanda, D., Sarkar, J., Konwar, R., Dwivedi, A., Negi, A.S. Synthesis of 2-alkoxy and 2-benzyloxy analogues of estradiol as anti-breast cancer agents through microtubule stabilization. European Journal of Medicinal Chemistry. 2014; 86: 740–751.
15.    Sathish Kumar, B., Singh, Aastha, Kumar, A., Singh, J., Hasanain, M., Singh, Arjun, Masood, N., Yadav, D.K., Konwar, R., Mitra, K., Sarkar, J., Luqman, S., Pal, A., Khan, F., Chanda, D., Negi, A.S. Synthesis of neolignans as microtubule stabilisers. Bioorganic and Medicinal Chemistry. 2014; 22: 1342–1354.
16.    Singh, A., Kumar, B.S., Alam, S., Iqbal, H., Shafiq, M., Khan, F., Negi, A.S., Hanif, K., Chanda, D. Diethyl-4,4ʹ-dihydroxy-8,3ʹ-neolign-7,7ʹ-dien-9,9ʹ-dionate exhibits AH activity in rats through increase in intracellular cGMP level and blockade of calcium channels. European Journal of Pharmacology. 2017; 799: 84–93.
17.    Singh, A., Kumar, B.S., Iqbal, H., Alam, S., Yadav, P., Verma, A.K., Khan, F., Shanker, K., Hanif, K., Negi, A.S., Chanda, D. AH activity of diethyl-4,4’-dihydroxy-8,3’-neolign-7,7’-dien-9,9’-dionate: A continuation study in L-NAME treated Wistar rats. Eur. J. Pharmacol. 2019; 858: 172482.
18.    Singh, A., Mohanty, I., Singh, J., Rattan, S. BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling and nonadrenergic noncholinergic relaxation via increased NO release. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2020; 318: G23–G33.
19.    Singh, A., Rattan, S. BDNF rescues aging-associated internal anal sphincter dysfunction. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2021; 321: G87–G97.
20.    Singh, A., Singh, J., Rattan, S. Evidence for the presence and release of BDNF in the neuronal and non‐neuronal structures of the internal anal sphincter. Neurogastroenterology and Motility. 2021.
21.    Singh, Aastha, Fatima, K., Singh, Arjun, Behl, A., Mintoo, M.J., Hasanain, M., Ashraf, R., Luqman, S., Shanker, K., Mondhe, D.M., Sarkar, J., Chanda, D., Negi, A.S. Anticancer activity and toxicity profiles of 2-benzylidene indanone lead molecule. European Journal of Pharmaceutical Sciences. 2015; 76: 57–67.
22.    Singh, Aastha, Fatima, K., Srivastava, A., Khwaja, S., Priya, D., Singh, Arjun, Mahajan, G., Alam, S., Saxena, A.K., Mondhe, D.M., Luqman, S., Chanda, D., Khan, F., Negi, A.S. Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer. Chem Biol Drug Des. 2016; 88: 625–634.
23.    Yadav, P., Iqbal, H., Kumar, K., Kumar, P., Mishra, D., Singh, A., Pal, A., Mukhopadhyay, P., Vamadevan, B., Singh, D., Negi, A.S., Chanda, D. 2-Benzyllawsone protects against polymicrobial sepsis and vascular hyporeactivity in swiss albino mice. European Journal of Pharmacology. 2022; 917: 174757.
24.    Manmohan, S., Arjun, S., Khan, S. P., Eram, S., and Sachan, N. K. Green chemistry potential for past, present and future perspectives. International Research Journal of Pharmacy. 2012; 3: 31-36.
25.    Singh A, Kumar BS, Alam S, Iqbal H, Shafiq M, Khan F, Negi AS, Hanif K, Chanda D. Corrigendum to "Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate exhibits AH activity in rats through increase in intracellular cGMP level and blockade of calcium channels" [Eur. J. Pharmacol. 799 (2017) 84-93]. Eur J Pharmacol. 2017 Jul 5;806:111. doi: 10.1016/j.ejphar.2017.04.033. Erratumfor: Eur J Pharmacol. 2017 Mar 15; 799:84-93. PMID: 28495016.
26.    Singh, A., R. Sharma, K. M. Anand, S. P. Khan, and N. K. Sachan. "Food-drug interaction." International Journal of Pharmaceutical and Chemical Science 1, no. 1 (2012): 264-279.
27.    M. Girija, N. Kokilavani. Effectiveness of Structured Teaching Programme on Knowledge, Attitude and Practice among Patients with Hypertension. Asian J. Nur. Edu. and Research. 2014;  4(1): 136-139.
28.    Devi. S, L N Samaga. Effect of transcendental meditation on stress and blood pressure among patients with systemic hypertension. Asian J. Nur. Edu. and Research. 2015; 5(1): 151-156.
29.    Lakshmi, K. Effectiveness of Nursing Care of Antenatal Mothers with Gestational Diabetes Mellitus. Asian Journal of Nursing Education and Research. 2020; 10(3): 286.
30.    Raju, Vidya, Jasmine Joy Bell, N. J. Merlin, and Shaiju S Dharan. Ethno Pharmacological Uses of Artocarpus Altilis -A Review. Asian Journal of Pharmaceutical Research. 2017; 7(4): 239.
31.    Somwanshi, Sachin B., Punam D. Bairagi, and Kiran B. Kotade. Study of Gestational Diabetes Mellitus: A Brief Review. Asian Journal of Pharmaceutical Research. 2017; 7(2): 118.
32.    Yousaf, Aqsa, and Sammia Shahid. The Study of Anethum Graveolens L. (Dill) in the Case of Diabetes Mellitus (DM). Asian Journal of Research in Pharmaceutical Science. 2020; 10(4): 248–56.
33.    Kavitha. T. A Study to Evaluate the Effectiveness of Structured Teaching Program on Modification of Daily Life Patterns Among Hypertensive Clients Attending OPD at Selected Hospital, Bangalore. Asian J. Nur. Edu. and Research. 2016; 6(1): 93-95.
34.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022;12(4):349-0. doi: 10.52711/2231-5713.2022.00055
35.    Preethi Jazna. B, Reeta Jebakumari, Nalini Jeyavantha Santha. A Study to Assess the Effectiveness of Benson Relaxation Therapy on Blood Pressure and Stress among Women with Pregnancy Induced Hypertension in Selected Hospitals, Madurai. Asian J. Nur. Edu. and Research. 2016; 6(2): 167-170.
36.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022; 12(4): 349-0. doi: 10.52711/2231-5713.2022.00055
37.    Devender Paswan, Urmila Pande, Alka Singh, Divya Sharma, Shivani Kumar, Arjun Singh. Epidemiology, Genomic Organization, and Life Cycle of SARS CoV-2. Asian Journal of Nursing Education and Research. 2023; 13(2):141-4.
38.    Arjun Singh, Rupendra Kumar, Sachin Sharma. Natural products and Hypertension: Scope and role in Antihypertensive Therapy. Asian Journal of Nursing Education and Research. 2023; 13(2):162-6.
39.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology.2022; 12(4):349-0.
40.    Arjun Singh, Rupendra Kumar. An Overview on Ethnopharmacological, Phytochemical, and Clinical Significance of Selected Dietary Polyphenols. Asian Journal of Research in Chemistry. 2023; 16(1):8-2.
41.    Arjun Singh. Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads. Asian Journal of Research in Chemistry. 2023; 16(1):43-8.
42.    Singh, A., Chanda, D., and Negi, A. S. (2018). Antihypertensive activity of Diethyl-4, 4'-dihydroxy-8, 3'-neolign-7, 7'-dien-9, 9'-dionate through increase in intracellular cGMP level and blockade of calcium channels (VDCC) and opening of potassium channel and in vivo models (SHRs and L-NAME induced hypertension). In Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology) (pp. PO1-2). Japanese Pharmacological Society.

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