Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Comparative In vivo Evaluation of Propranolol hydrochloride following Oral and Transdermal administration in Rabbits

Author(s): V. Sai Kishore, T. E. Gopala Krishna Murthy, C. Mayuren

Email(s): voiceofsaikishore@yahoo.com

DOI: Not Available

Address: V. Sai Kishore,* T. E. Gopala Krishna Murthy and C. Mayuren
Bapatla College of Pharmacy, Bapatla-522101
*Corresponding Author

Published In:   Volume - 4,      Issue - 3,     Year - 2011

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ABSTRACT:
Membrane-moderated transdermal systems of Propranolol hydrochloride were prepared by incorporating the drug reservoir within a shallow compartment moulded from a drug-impermeable backing membrane and 2% w/v cellulose acetate rate-controlling membrane casted with ethyl acetate-methanol (8:2) employing dibutyl phthalate (40% w/w of dry polymer) as plasticizer. The pharmacodynamic and pharmacokinetic performance of Propranolol hydrochloride following transdermal administration was compared with that of oral administration. This study was carried out in a randomized cross-over design in male New Zealand albino rabbits. The estimation of Propranolol hydrochloride in plasma was carried out by LC-MS/MS method. The parameters such as maximum plasma concentration (Cmax), time for peak plasma concentration (tmax), mean residence time (MRT) and area under curve (AUC0 - 8) were significantly (P< 0.001) differed following transdermal administration compared to oral administration. The terminal elimination half life of transdermally delivered of Propranolol hydrochloride was found to similar that of oral administration. The relative bioavailability of Propranolol hydrochloride was increased about six fold after transdermal administration as compared to oral delivery. This may be due to the avoidance of first pass effect of Propranolol hydrochloride. In agreement with pharmacokinetic data, maximum ß -blockade was obtained at 1 h after oral administration and decreased by 80% after 6 h. In the case of transdermal administration, a steady state ß-blockade.was observed after 12.0 h and was prolonged over a period of 24 h. It was concluded that the relative rate of extensive first pass metabolism was significantly reduced in transdermal administration, resulted in increased relative bioavailability and reduced frequency of administration.


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Cite this article:
V. Sai Kishore, T. E. Gopala Krishna Murthy, C. Mayuren. Comparative In vivo Evaluation of Propranolol hydrochloride following Oral and Transdermal administration in Rabbits. Asian J. Research Chem. 4(3): March 2011; Page 461-465.

Cite(Electronic):
V. Sai Kishore, T. E. Gopala Krishna Murthy, C. Mayuren. Comparative In vivo Evaluation of Propranolol hydrochloride following Oral and Transdermal administration in Rabbits. Asian J. Research Chem. 4(3): March 2011; Page 461-465.   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2011-4-3-27


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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