Author(s):
Chandradeep Bhaidas Jagdeo, Kalpesh Vilas Khairnar, Amol R. Pawar, Pankaj S. Patil, Vikas V. Patil
Email(s):
chandradeepjagdeo7203@gmail.com
DOI:
10.52711/0974-4150.2026.00085 
Address:
Chandradeep Bhaidas Jagdeo1, Kalpesh Vilas Khairnar1, Amol R. Pawar1,2*, Pankaj S. Patil1, Vikas V. Patil1
1Department of Quality Assurance, Kisan Vidya Prasarak Sanstha’s Institute of Pharmaceutical Education, Boradi 425428, Maharashtra, India.
2Research Scholar, Sankalchand Patel University, Visnagar – 384315, Gujarat, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
Pharmaceutical quality assurance depends on analytical procedures that are simultaneously accurate, robust and defensible before regulators, yet these procedures remain among the most solvent-intensive activities in the industry. Green analytical chemistry (GAC) has evolved over two decades from scattered waste-minimisation practice into a structured discipline supported by codified principles, quantitative assessment metrics and growing regulatory endorsement. This review examines that trajectory and asks whether greener methods can be genuinely reconciled with the performance and compliance demands of pharmaceutical quality control, rather than merely coexisting with them. Seven technique families green liquid chromatography, capillary electrophoresis, spectroscopic/chemometric approaches, green sample preparation, microextraction, supercritical fluid chromatography, and ambient ionisation mass spectrometry are compared for analytical performance, environmental burden, operating cost, and industrial deployability. Solvent and waste reductions are substantial but unevenly distributed, and frequently accompanied by losses in sensitivity, throughput or transferability that the primary literature under-reports. The proliferation of greenness metrics (Eco-Scale, NEMI, GAPI, AGREE and their derivatives) has improved transparency while introducing scoring inconsistency and weighting subjectivity. The convergence of ICH Q14 and Q2(R2) with analytical quality by design offers the most credible route to embedding sustainability within the analytical lifecycle, though validated cross-metric harmonization, whole-lifecycle assessment and industrial implementation data remain scarce.
Cite this article:
Chandradeep Bhaidas Jagdeo, Kalpesh Vilas Khairnar, Amol R. Pawar, Pankaj S. Patil, Vikas V. Patil. Advances in Green Analytical Techniques and Their Impact on Quality Assurance in the Pharmaceutical Industry: A Critical Review. Asian Journal of Research in Chemistry.2026; 19(6):605-6. doi: 10.52711/0974-4150.2026.00085
Cite(Electronic):
Chandradeep Bhaidas Jagdeo, Kalpesh Vilas Khairnar, Amol R. Pawar, Pankaj S. Patil, Vikas V. Patil. Advances in Green Analytical Techniques and Their Impact on Quality Assurance in the Pharmaceutical Industry: A Critical Review. Asian Journal of Research in Chemistry.2026; 19(6):605-6. doi: 10.52711/0974-4150.2026.00085 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2026-19-6-12
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