Chemical Components Isolated from Melia azedarach L.

Meera; Sweety Monga; Malvika Kadian; Savita Nagoria; Satyender Kumar; Virender Kumar

doi:10.52711/0974-4150.2026.00079

Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)

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Chemical Components Isolated from Melia azedarach L.

Author(s): Meera, Sweety Monga, Malvika Kadian, Savita Nagoria, Satyender Kumar, Virender Kumar

Email(s): sw.chemistry@gmail.com

DOI: 10.52711/0974-4150.2026.00079

Address: Meera1, Sweety Monga1*, Malvika Kadian1, Savita Nagoria1, Satyender Kumar2, Virender Kumar3
1Department of Chemistry, GGJ Government College, Hisar - 125001, Haryana, India.
2Department of Chemistry, Government College for Women, Hisar - 125001, Haryana, India.
3Department of Chemistry, Khalsa Tri – Centenary Government College, Ratia - 125051, Haryana, India.
*Corresponding Author

Published In: Volume - 19, Issue - 6, Year - 2026

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ABSTRACT:
Melia azedarach L, is a member of Meliaceae and is a fast-growing deciduous tree indigenous to Asia and Australia. The plant is abundant source of bioactive compounds mainly limonoids, terpenoids and steroids. It also contains flavonoids, lignans and anthraquinones. The plant is known to possess anthelmintics, antibacterial, insecticidal and pharmacological properties. Various extracts from different parts and compounds isolated from M. azedarach have established various medicinal and pesticidal properties, showing its effectiveness against plentiful of pathogenic and pest organisms.

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Cite this article:
Meera, Sweety Monga, Malvika Kadian, Savita Nagoria, Satyender Kumar, Virender Kumar. Chemical Components Isolated from Melia azedarach L. Asian Journal of Research in Chemistry.2026; 19(6):553-2. doi: 10.52711/0974-4150.2026.00079

Cite(Electronic):
Meera, Sweety Monga, Malvika Kadian, Savita Nagoria, Satyender Kumar, Virender Kumar. Chemical Components Isolated from Melia azedarach L. Asian Journal of Research in Chemistry.2026; 19(6):553-2. doi: 10.52711/0974-4150.2026.00079 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2026-19-6-6

REFERENCES:
1. Lorenzi, H. Brazilian trees: Identification and cultivation of tree plants in Brazil. 2009, 3.ed., Nova Odessa, Instituto Plantarum.
2. Satyavati, G. V.; Raina, M. K.; Sharma, M. Medicinal Plants of India, Indian council of Medical Research, New Delhi. 1976, pp. 201–206.
3. Al-Rubae, A.Y. The Potential uses of Melia azedarach L. as pesticidal and medicinal plant, Review. American-Eurasian Journal of Sustainable Agriculture. 2009; 3(2): 185-194.
4. Kumar R, Singh R, Suhag P, Meera and Kalidhar SB. Chemical components and Insecticidal properties of Bakain (Melia azedarach L.) – A Review. Agricultural Reviews. 2003, 24(2): 101 – 115.
5. Srivastava SD and Srivastava SK. Insect antifeedant novel limonoids from the roots of Melia azedarach. Journal of the Indian Chemical Society. 1996; 73(9): 467-469.
6. Yuan CM, Zhang Y, Tang GH, Li Y, He HP, Li SF, Hou Li, Li XY, Di YT, Li SL, Hua, HM and Hao XJ. Cytotoxic limonoids from Melia azedarach. Planta Medica. 2013; 79: 163-168. http://dx.doi.org/10.1055/s-0032-1328069
7. Zhang WM, Liu JQ, Peng XR, Wan LS, Zhang ZR, Li ZR and Qiu MH. Triterpenoids and sterols from the leaves and twigs of Melia azedarach. Natural Products and Bioprospecting. 2014; 4: 157-162. https://doi.org/10.1007/s13659-014-0019-1
8. Srivastava SK and Gupta HO. New Limonoids from the roots of Melia-azedarach Linn. Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry. 1985; 24(2): 166-170.
9. Srivastava SD. Limonoids from the seeds of Melia azedarach. Journal of Natural Products. 1986, 49(1); 56-61. https://doi.org/10.1021/np50043a005
10. Nakatani M, Huang RC, Okamura H, Iwagawa T and Tadera K. Degraded limonoids from Melia azedarach. Phytochemistry. 1998; 49 (6): 1773–1776. https://doi.org/10.1016/s0031-9422(98)00262-3.
11. Fukuyama Y, Nakaoka M, Yamamoto T, Takahashi H and Minami H. Degraded and oxetane-bearing limonoids from the roots of Melia azedarach. Chemical and Pharmaceutical Bulletin. 2006; 54 (8): 1219–1222. https://doi.org/10.1248/cpb.54.1219.
12. Ambrosio DM and Guerriero A. Degraded limonoids from Melia azedarach and biogenetic implications. Phytochemistry. 2002; 60 (4): 419–424. https://doi.org/10.1016/s0031-9422(02)00107-3.
13. Abdel-Aty, AS and Abdel-Megeed A. Pesticidal activity of an isolated limonoid from Melia azedarach L. fruits. Journal of Animal Plant Science. 2015; 25(2): 519-527. https://www.researchgate.net/publication/271120038
14. Ekong DEU, Fakunle CO, Fasina AK and Okogun JI. The meliacins (limonoids). Nimbolin A and B, two new meliacin cinnamates from Azadirachta indica L. and Melia azedarach L. Journal of the Chemical Society D: Chemical Communications. 1969; 20: 1166-1167.
15. Okogun JI, Fakunle CO, Ekong DE and Connolly JD. Chemistry of the meliacins (limonoids). The structure of melianin A, a new protomeliacin from Melia azedarach. Journal of the Chemical Society, Perkin Transactions 1. 1975; No. 14: 1352. https://doi.org/10.1039/P19750001352
16. Su ZS, Yang SP, Zhang S, Dong L and Yue JM. Meliarachins A–K: Eleven limonoids from the twigs and leaves of Melia azedarach. Helvetica Chimica Acta. 2011; 94(8): 1515-1526. https://doi.org/10.1002/hlca.201000444
17. Zhang SN, Huang L, Ma RJ, Yang MF, Wei BF, Song HZ, Wang HS and Tan QG. Chemical constituents from the barks of Melia azedarach and their PTP1B inhibitory activity. Natural Product Research. 2020; 35(22): 4442–4447. https://doi.org/10.1080/14786419.2020.1729146.
18. Ochi M and Kotsuki H. Sendanal, a new limonoid from Melia azedarach Linn. var. Japonica Makino. Chemistry Letters. 1978; 7 (6): 621–624. https://doi.org/10.1246/cl.1978.331.
19. Pan X, Matsumoto M, Nakamura Y, Kikuchi T, Zhang J, Ukiya M, Suzuki T, Koike K, Akihisa R and Akihisa T. Three new and other limonoids from the hexane extract of Melia azedarach fruits and their cytotoxic activities. Chemistry and Biodiversity, 2014; 11(7): 987–1000. https://doi.org/10.1002/cbdv.201400052.
20. Song M, Zhang J, Chan G, Hou Y, Chen XP, Zhang XQ, Ye WC and Zhang QW. Bioactive Limonoids and Triterpenoids from the Fruits of Melia azedarach. Journal of Natural Products. 2020; 83(12): 3502–3510. https://doi.org/10.1021/acs.jnatprod.9b01151.
21. Song M, Luo HJ, Li Z W, Qiu L, Zhao YX, He CW, Zhang XQ, Ye WC, Lin LG and Zhang QW. Limonoids from the roots of Melia azedarach and their anti-inflammatory activity. Phytochemistry, 2023; 216: 113869–113869. https://doi.org/10.1016/j.phytochem.2023.113869.
22. Ge JJ, Wang LT, Chen P, Zhang Y, Lei XX and Ye XX. Two new tetracyclic triterpenoids from the barks of Melia azedarach. Journal of Asian Natural Products Research. 2016; 18(1): 20–25. https://doi.org/10.1080/10286020.2015.1124866.
23. Wang WQ, Xia ZZ, Yu SH, Tian ZH, Yan B, Jiang HQ and Zhou HL. Two new limonoids from the fruits of Melia azedarach (Meliaceae). Chemistry and Biodiversity. 2020; 18(2): e2000822. https://doi.org/10.1002/cbdv.202000822.
24. Alché LE, Assad Ferek G, Meo M, Coto CE, and Maier M. S. An antiviral meliacarpin from leaves of Melia azedarach L. Zeitschrift für Naturforschung C. 2003; 58(3-4): 215–219. https://doi.org/10.1515/znc-2003-3-413.
25. Bohnenstengel FI, Wray V, Witte L, Srivastava RP and Proksch P. Insecticidal meliacarpins (C-seco limonoids) from Melia azedarach. Phytochemistry. 1999; 50(6): 977–982. https://doi.org/10.1016/s0031-9422(98)00644-x
26. Lee SM, Klocke JA and Balandrin MF. The structure of 1-cinnamoyl melianolone, a new insecticidal tetranortriterpenoid, from Melia azedarach L. (Meliaceae). Tetrahedron Letters. 1987; 28(31): 3543–3546. https://doi.org/10.1016/s0040-4039(00)95530-8
27. Jin Q, Lee C, Woo Lee J, Yeon Choi J, Tae Hong J, Kim Y, Le MK and Yeon Hwang B. Two New C‐seco Limonoids from the Fruit of Melia azedarach. Helvetica Chimica Acta. 2014; 97(8): 1152–1157. https://doi.org/10.1002/hlca.201400045.
28. Morgan ED and Thornton MD. Azadirachtin in the fruit of Melia azedarach. Phytochemistry.1973; 12(2): 391–392. https://doi.org/10.1016/0031-9422(73)80025-1
29. Takeya K, Qiao ZS, Hirobe C and Itokawa H. Cytotoxic azadirachtin-type limonoids from Melia azedarach. Phytochemistry. 1996; 42(3): 709–712. https://doi.org/10.1016/0031-9422(96)00044-1
30. Abdelghany AM, Farag M, Yousef H, and Ahmed MH. Insecticidal activity of Melia azedarach L. triterpeniods against Spodoptera littoralis (Boisd.). Journal of American Science. 2012. ; 8(3), 661-667. https://www.researchgate.net/publication/277306237
31. Fukuyama Y, Ogawa M, Takahashi H and Minami H. Two new meliacarpinins from the roots of Melia azedarach. Chemical and Pharmaceutical Bulletin. 2000; 48(2): 301–303. https://doi.org/10.1248/cpb.48.301.
32. Nargund RR, Kulkarni VH, Habbu PV, Joshi AB, Goude T and Madagundi SD. Isolation, characterization of seconadry metabolites from the Melia azedarach Linn. Root and to evaluate their in vitro antidiabetic activity. Journal of Pharmacognosy and Phytochemistry. 2018; 7(1): 2214-2220.
33. Tan QG, Li XN, Chen H, Feng T, Cai XH and Luo XD. Sterols and terpenoids from Melia azedarach. Journal of Natural Products. 2010; 73(4): 693–697. https://doi.org/10.1021/np1000472
34. Tan QG, Lai CH, Zhang GJ, Chen YF, Qin DJ and Wang HS. Chemical constituents from Melia azedarach and their anti-diabetes activities. Natural Product Research and Development. 2014; 26(2): 162 – 166.
35. Nakatani M, Huang RC, Okamura H, Iwagawa T, Tadera K and Naoki H. Three new antifeeding meliacarpinins from Chinese Melia azedarach Linn. Tetrahedron. 1995; 51(43): 11731–11736. https://doi.org/10.1016/0040-4020(95)00724-m.
36. Huang RC, Zhou JB, Suenaga H, Takezaki K, Tadera K and Nakatani M. Insect antifeeding property of limonoids from Okinawan and Chinese Melia azedarach L., and from Chinese Melia toosendan (Meliaceae). Bioscience, Biotechnology, and Biochemistry. 1995; 59(9): 1755–1757. https://doi.org/10.1271/bbb.59.1755.
37. Nakatani M, Huang RC, Okamura H and Iwagawa T. The structure of a new antifeeding meliacarpinin from chines Melia azedarach L. Chemistry Letters. 1993; 22(12): 2125–2128. https://doi.org/10.1246/cl.1993.2125.
38. Itokawa H, Qiao ZS, Hirobe C and Takeya K. Cytotoxic limonoids and tetranortriterpenoids from Melia azedarach. Chemical and Pharmaceutical Bulletin. 1995; 43(7): 1171–1175. https://doi.org/10.1248/cpb.43.1171
39. Huang RC, Tadera K, Yagi F, Minami Y, Okamura H, Iwagawa T and Nakatani M. Limonoids from Melia azedarach. Phytochemistry. 1996; 43(3): 581–583. https://doi.org/10.1016/0031-9422(96)00353-6.
40. Zhou, H.; Atsuko Hamazaki; Jose Domingos Fontana; Takahashi, H.; Carolina Bueno Wandscheer; Fukuyama, Y. Chemical & Pharmaceutical Bulletin, 2005, 53(10), 1362–1365. https://doi.org/10.1248/cpb.53.1362.
41. Ruo CH, Minami Y, Yagi F, Nakamura Y, Nakayama N, Tadera K and Nakatani M. Melianolide, a new limonoid of biogenetic interest, from Chinese Melia azedarach L. Heterocycles. 1996; 7(43): 1477-1482.
42. Jeong H, Park S, Kim SY, Cho SH, Jeong MS, Kim SR, Seo JB, Kim SH and Kim KN. 1-Cinnamoyltrichilinin from Melia azedarach causes apoptosis through the p38 MAPK Pathway in HL-60 human leukemia cells. International Journal of Molecular Sciences. 2020; 21(20): 7506–7506. https://doi.org/10.3390/ijms21207506.
43. ‌ Park S, Nhiem NX, Subedi L, Oh I, Kim JY, Kim SY and Kim SH. Isolation of bioactive limonoids from the fruits of Melia azedarach. Journal of Asian Natural Products Research. 2020; 22(9): 830-838. https://doi.org/10.1080/10286020.2019.1666826
44. Liu HB, Zhang CR, Dong SH, Dong L, Wu Y and Yue JM. Limonoids and triterpenoids from the seeds of Melia azedarach. Chemical and Pharmaceutical Bulletin. 2011; 59(8): 1003–1007. https://doi.org/10.1248/cpb.59.1003
45. Lu Q, Li H, Rong XU, Jun L and Yi LI. Two new nimbolinin-and trichilin-class limonoids isolated from the fruits of Melia azedarach. Chinese Journal of Natural Medicines. 2019; 17(3): 227–230. https://doi.org/10.1016/s1875-5364(19)30025-1
46. Nakatani M, Huang RC, Okamura H, Iwagawa T and Tadera K. Salannal, a new limonoid from Melia azedarach Linn. Chemistry Letters. 1995; 24(11): 995–996. https://doi.org/10.1246/cl.1995.995
47. Akihisa T, Pan X, Nakamura Y, Kikuchi T, Takahashi N, Matsumoto M, Ogihara E, Fukatsu M, Koike K and Tokuda H. Limonoids from the fruits of Melia azedarach and their cytotoxic activities. Phytochemistry. 2013; 89: 59–70. https://doi.org/10.1016/j.phytochem.2013.01.015
48. Zhou H, Hamazaki A, Fontana JD, Takahashi H, Esumi T, Wandscheer CB, Tsujimoto H and Fukuyama Y. New Ring C-s eco Limonoids from Brazilian Melia azedarach and Their Cytotoxic Activity. Journal of Natural Products. 2004; 67(9): 1544–1547. https://doi.org/10.1021/np040077r.
49. Díaz M, Castillo L, Diaz CE, González-Coloma A and Rossini C. Limonoids from Melia azedarach with deterrent activity against insects. The Natural Products Journal. 2012; 2(1): 36-44.
50. Fukuyama Y, Miura I, and Ochi M. Bitter limonoids from the fruit of Melia azedarach L. var. japonica Makino. Bulletin of the Chemical Society of Japan. 1983; 56(4): 1139–1142. https://doi.org/10.1246/bcsj.56.1139
51. Ochi M, Kotsuki H, Ido M, Nakai H, Shiro M and Tokoroyama T. The structures of ohchinolide A and B, two new limonoids from Melia azedarach Linn. var. japonica Makino. Chemistry Letters. 1979; 8(9): 1137–1140. https://doi.org/10.1246/cl.1979.1137.
52. Pan X, Matsumoto M, Nishimoto Y, Ogihara E, Zhang J, Ukiya M, Tokuda H, Koike K, Akihisa M and Akihisa T. Cytotoxic and nitric oxide production‐inhibitory activities of limonoids and other compounds from the leaves and bark of Melia azedarach. Chemistry and Biodiversity, 2014; 11(8): 1121–1139. https://doi.org/10.1002/cbdv.201400190.
53. Ochi M, Kotsuki H, Kataoka T, Tada T and Tokoroyama T. Limonoids from Melia azedarach Linn. var. Japonica Makino. III. The structures of ohchinal and ohchinin acetate. Chemistry Letters. 1978; 7(4): 331–334. https://doi.org/10.1246/cl.1978.331
54. Rani M, Suhag P, Kumar R, Singh R and Kalidhar SB. Chemical components and biological efficacy of Melia azedarach Stems. Journal of Medicinal and Aromatic Plant Sciences. 1999; 21(4): 1043-1047.
55. Takeya K, Qiao ZS, Hirobe C and Itokawa H. Cytotoxic trichilin-type limonoids from Melia azedarach. Bioorganic and Medicinal Chemistry, 1996; 4(8): 1355–1359. https://doi.org/10.1016/0968-0896(96)00128-9
56. Huang RC, Okamura H, Iwagawa T and Nakatani M. The Structures of Azedarachins, Limonoid Antifeedants from Chinese Melia azedarach Linn. Bulletin of the Chemical Society of Japan. 1994; 67(9): 2468–2472. https://doi.org/10.1246/bcsj.67.2468
57. Nakatani M, Huang RC, Okamura H, Naoki H and Iwagawa T. 1994. Limonoid antifeedants from Chinese Melia azedarach. Phytochemistry. 1994; 36(1): 39–41. https://doi.org/10.1016/s0031-9422(00)97008-0.
58. Ahn JW, Choi SU and Lee CO. Cytotoxic limonoids from Melia azedarach var. japonica. Phytochemistry. 1994; 36(6): 1493-1496. https://doi.org/10.1016/S0031-9422(00)89749-6
59. Carpinella C, Ferrayoli C, Valladares G, Defago M, and Palacios S. Potent limonoid insect antifeedant from Melia azedarach. Bioscience Biotechnology and Biochemistry. 2002; 66(8): 1731–1736. https://doi.org/10.1271/bbb.66.1731
60. Carpinella MC, Defago MT, Valladares G and Palacios SM. Antifeedant and insecticide properties of a limonoid from Melia azedarach (Meliaceae) with potential use for pest management. Journal of Agricultural and Food Chemistry. 2003; 51(2): 369–374. https://doi.org/10.1021/jf025811w.
61. Ahn JW, Yoo GS, No Z and Lee SH. 12-Hydroxyamoorastatone, a new limonoid from Melia azedarach var. japonica. Bulletin of the Korean Chemical Society. 1993; 14(5): 554-556. https://doi.org/10.5012/bkcs.1993.14.5.554
62. Huang RC, Okamura H, Iwagawa T, Tadera K and Nakatani M. Azedarachin C, a limonoid antifeedant from Melia azedarach. Phytochemistry. 1995; 38(3): 593–594. https://doi.org/10.1016/0031-9422(94)00707-z.
63. Kikuchi T, Pan X, Ishii K, Nakamura Y, Ogihara E, Koike K, Tanaka R and Akihisa T. Cytotoxic and apoptosis-inducing activities of 12-O-Acetylazedarachin B from the fruits of Melia azedarach in human cancer cell lines. Biological and Pharmaceutical Bulletin. 2013; 36(1): 135–139. https://doi.org/10.1248/bpb.b12-00795.
64. Srivastava SD. Further constituent from the seeds of Melia azedarach. Planta Medica. 1987; 53(1): 100-101. https://doi.org/10.1055/s-2006-962635
65. Oelrichs PB, Hill MW, Vallely PJ, MacLeod JK and Molinski TF. Toxic tetranortriterpenes of the fruit of Melia azedarach. Phytochemistry. 1983; 22(2): 531–534. https://doi.org/10.1016/0031-9422(83)83039-8.
66. Tuan NN, Kuo PC, Hoang VD, Hien VT, Quang LD, Hieu TT, Li YC, Thanh NT, Wu TS and Thang TD. The limonoids and other constituents from the fruits of Melia azedarach and their biological activity. Records of Natural Products. 2022; 4: 307–315. https://doi.org/10.25135/rnp.277.21.06.2097.
67. Ochi M, Kotsuki H, Hirotsu K and Tokoroyama T. Sendanin, a new limonoid from Melia azedarach Linn. var. Japonica Makino. Tetrahedron Letters. 1976; 17(33): 2877–2880. https://doi.org/10.1016/s0040-4039(01)85526-x.
68. Zhou F, Ma XH, Li ZJ, Li W, Zheng WM, Wang ZB, Zeng X, Sun K and Zhang YH. Four new tirucallane triterpenoids from the fruits of Melia azedarach and their cytotoxic activities. Chemistry and Biodiversity. 2016; 13(12): 1738–1746. https://doi.org/10.1002/cbdv.201600149.
69. Saxena M and Srivastava SK. A New Limonoid Glycoside from the Stem Bark of Melia azedarach Linn. Indian Journal of Chemistry. 1986; 25B(10): 1087-1088.
70. Jin Q, Lee C, Lee JW, Lee MS, Lee MK and Hwang BY. A New Apotirucallane-type triterpenoid from the Fruit of Melia azedarach. Natural Product Sciences. 2013; 19(4): 342-346.
71. Song M, Chan G, Lin LG, Li D, Zhang K, Zhang XQ, Ye WC, Li N and Zhang QW. Triterpenoids from the fruits of Melia azedarach L. and their cytotoxic activities. Phytochemistry; 2022; 201: 113280–113280. https://doi.org/10.1016/j.phytochem.2022.113280.
72. Tan QG. Triterpenoids and sterols from Melia azedarach and their anti-diabetes activities. Chinese Traditional and Herbal Drugs. 2014; 913-918.
73. Wu SB, Bao QY, Wang WX, Zhao Y, Xia G, Zhao Z, Zeng H and Hu JF. Cytotoxic triterpenoids and steroids from the bark of Melia azedarach. Planta Medica. 2011; 77(9): 922–928. https://doi.org/10.1055/s-0030-1250673
74. Ntalli NG, Cottiglia F, Bueno CA, Alché LE, Leonti M, Vargiu S, Bifulco E, Spiroudi UM and Caboni P. Cytotoxic tirucallane triterpenoids from Melia azedarach fruits. Molecules. 2010; 15(9): 5866–5877. https://doi.org/10.3390/molecules15095866
75. Schulte KE, Ruecker G and Matern HU. Some constituents of the fruits and root of Melia azedarach L [drug plants]. Planta Medica (Germany, FR). 1979; 35(1): 76 – 83.
76. Faizi S, Wasi A, Siddiqui BS and Naz A. New terpenoids from the roots of Melia azedarach. Australian Journal of Chemistry. 2002; 55(4): 291. https://doi.org/10.1071/ch01101.
77. Sanna G, Madeddu S, Giliberti G, Ntalli NG, Cottiglia F, De Logu A, Agus E and Caboni P. Limonoids from Melia azedarach Fruits as Inhibitors of Flaviviruses and Mycobacterium tubercolosis. PLOS ONE. 2015; 10(10): e0141272–e0141272. https://doi.org/10.1371/journal.pone.0141272.
78. Wang W, Xia Z, Tian Z, Jiang H, Zhan Y, Liu C. Li C and Zhou H. Chemical constituents from the fruits of Melia azedarach (Meliaceae). Biochemical Systematics and Ecology. 2020; 92: 104094. https://doi.org/10.1016/j.bse.2020.104094
79. Ma X, Zhou F, Deng Y, Sun K, Zhang H, Zeng X, Zhang Y and Yu X. A new steroid ester from the leaves of Melia azedarach. Chemistry of Natural Compounds. 2018; 54: 921-925.
80. Jabeen K, Javaid A, Ahmad E and Athar M. Antifungal compounds from Melia azedarach leaves for management of Ascochyta rabiei, the cause of chickpea blight. Natural Product Research. 2011; 25(3): 264–276. https://doi.org/10.1080/14786411003754298.
81. Bharti, Suhag P, Kumar R, Singh R and Kalidhar SB. Phytochemical investigation of Melia azedarach seeds. Journal of Medicinal and Aromatic Plant Sciences. 2002; 24(1): 33 - 35.
82. Kelecom A, Cabral MMO and Garcia ES. A new euphane triterpene from the Brazilian Melia azedarach. Journal of the Brazilian Chemical Society. 1996; 7(1): 39–41. https://doi.org/10.5935/0103-5053.19960006.
83. Suhag P, Mahla M, Singh R and Kalidhar SB. Phytochemical investigation of Melia azedarach roots. Journal of the Indian Chemical Society. 2002; 79(6): 548-549.
84. Chiang CK, and Chang FC. Tetracyclic triterpenoids from Melia azedarach, L.—III. Tetrahedron. 1973; 29(14): 1911–1929. https://doi.org/10.1016/0040-4020(73)80126-7.
85. Chang F C, Chiang C K. Kulinone, a euphane-type triterpenoid from Melia azedarach, L. Chemical Communications (London). 1968; 19:1156-1158.
86. Han J, Lin WH, Xu RS, Wang WL and Zhao SH. Studies on the chemical constituents of Melia azedarach L. Acta Pharmaceutica Sinica. 1991; 26(6): 426-429. PMID: 1789108
87. Lavie D, Jain MK, Kirson I. Terpenoids: Part IV. The complete structure of Melianone. Journal of the Chemical Society C Organic. 1967; 1347–1347. https://doi.org/10.1039/j39670001347.
88. Ochi M, Kotsuki H, Tokoroyama T and Kubota T. The structure of sendanolactone, a new triterpenoid from Melia azedarach L. var. japonica Makino. Bulletin of the Chemical Society of Japan. 1977; 50(9): 2499–2500. https://doi.org/10.1246/bcsj.50.2499.
89. Wu SB, Ji YP, Zhu JJ, Zhao Y, Xia G, Hu YH and Hu JF. Steroids from the leaves of Chinese Melia azedarach and their cytotoxic effects on human cancer cell lines. Steroids. 2009; 74(9): 761–765. https://doi.org/10.1016/j.steroids.2009.04.005
90. Ervina M, Poerwono H, Widyowati R, Otsuka H, Matsunami K, and Sukardiman S. Pregnane steroids from the leaves of Melia azedarach and apoptotic activity against T47D Cells. Journal of Cancer Prevention. 2021; 22(6): 1967–1973. https://doi.org/10.31557/apjcp.2021.22.6.1967.
91. Nakatani M, Takao H, Miura I and Hase T. Azedarachol, a steroid ester antifeedant from Melia azedarach var. Japonica. Phytochemistry.1985; 24(9): 1945–1948. https://doi.org/10.1016/s0031-9422(00)83097-6.
92. Nair MG and Chang FC. 6β-Hydroxy-4-stigmasten-3-one and 6β-hydroxy-4-campesten-3-one. Phytochemistry. 1973; 12(4): 903–906. https://doi.org/10.1016/0031-9422(73)80700-9.
93. Chong X, Tian G, Cheng Z and Yao Q. Study on chemical constituents of the seed of Melia azedarach L. Food and Drug. 2009; 11(3): 30-31.
94. Fufa MF, Deressa F, Deyou T and Abdisa N. Isolation and characterization of compounds from the leaves of Melia azedarach and stem bark of Albizia schimperiana and evaluation for antimicrobial activities. Medicinal Chemistry. 2018; 8(6). https://doi.org/10.4172/2161-0444.1000507.
95. ‌ Zeng J, Zhang SN, Song HZ, Ma RJ and Tan QG. Flavonoid and Lignan Glycosides from the Leaves of Melia azedarach. Chemistry of Natural Compounds. 2020; 56: 323-324.
96. Mishra M and Srivastava SK. A new flavone glycoside from Melia azedarach Linn. Current Science. 1984; 53: 694 – 695.
97. Gupta HO and Srivastava SK. Apigenin-5-O-galactoside from the roots of Melia azedarach, Linn. Current Science. 1985; 54: 570 -571.
98. Zeng J, Ma RJ, Wang L, Zhang SN, Song HZ, Yang Y and Tan QG. Chemical constituents from the leaves of Melia azedarach. Natural Product Research. 2018; 33(19): 2860–2863. https://doi.org/10.1080/14786419.2018.1501690
99. Salib JY, Michael HN and El-Nogoumy SI. New lactoyl glycoside Quercetin from Melia azedarach leaves. Chemistry of Natural Compounds. 2008; 44: 13-15.
100. Jafari S, Saeidnia S, Hajimehdipoor H, Ardekani MRS, Faramarzi MA, Hadjiakhoondi A and Khanavi M. Cytotoxic evaluation of Melia azedarach in comparison with, Azadirachta indica and its phytochemical investigation. DARU Journal of Pharmaceutical Sciences. 2013; 21: 1-7.
101. Kumazawa S, Kubota S, Yamamoto H, Okamura N, Sugiyama Y, Kobayashi H, Nakanishi M and Ohta T. Antiangiogenic activity of flavonoids from Melia azedarach. Natural Product Communications. 2013; 8(12): 1719-1720. https://doi.org/10.1177/1934578x1300801215.
102. Marco JA, Barbera O, Sanz JF and Sanchez-Parareda J. Flavonol diglycosides from Melia azedarach. Journal of Natural Products. 1986; 49(1): 170–170. https://doi.org/10.1021/np50043a030.
103. Nair AGR, Subramanian SS. Quercetin glycoside from leaves of Soymida febrifuga and Melia azedarach. Indian Journal of Chemistry. 1975; 13: 527.
104. Srivastava S and Mishra M. New anthraquinone pigments from the stem bark of Melia azedarach linn. Indian Journal of Chemistry. 1985; 24(B): 793-794.
105. Cabral MM, Garcia ES, and Kelecom A. Lignanes from the Brazilian Melia azedarach, and their activity in Rhodnius prolixus (Hemiptera, Reduviidae). Memórias do Instituto Oswaldo Cruz. 1995; 90(6): 759–763. https://doi.org/10.1590/s0074-02761995000600018
106. Fa-gu Z, Qian SU, Ying-tong DI and Xiao-jiang HAO. Penylpropanoids with Cytotoxic Activity from the Fruits of Melia azedarach. Natural Product Research and Development. 2016; 28(8): 1171 - 1175.
107. Carpinella MC, Ferrayoli CG, and Palacios SM. Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits. Journal of agricultural and Food Chemistry. 2005; 53(8): 2922-2927. https://doi.org/10.1021/jf0482461
108. Suhag P, Meera and Kalidhar SB. Phytochemical investigation of Melia azedarach leaves. Journal of Medicinal and Aromatic Plant Sciences. 2003; 25(2): 397-399.
109. LI S, Deng J and Zhao S. Minor phenolic constituents of chinaberry-tree (Melia azedarach). Chinese Traditional and Herbal Drugs. 2000; 86-89.
110. Alché LE, Barquero AA, Sanjuan NA and Coto CE. An antiviral principle present in a purified fraction from Melia azedarach L. leaf aqueous extract restrains Herpes simplex virus type 1 propagation. Phytotherapy Research. 2002; 16(4): 348–352. https://doi.org/10.1002/ptr.895.
111. Akbar M, Javaid A, Khalil T and Iqbal MS. Isolation of herbicidal compounds from Melia azedarach L. to control Rumex dentatus L. in wheat. Allelopathy Journal. 2022; 55(2): 163-176. https://doi.org/10.26651/allelo.j/2021-55-2-1378