Development of UV Spectrophotometric Method for the Simultaneous Estimation of Domperidone and Omeprazole in Capsule Dosage Form by Simultaneous Equation and Absorbance Ratio Method.

Varsha Balkrishna Mane; Surekha Babar; Karishma Waghmare; Anita S. Kulkarni

Asian Journal of Research in Chemistry

ISSN

0974-4150 (Online)
0974-4169 (Print)

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Development of UV Spectrophotometric Method for the Simultaneous Estimation of Domperidone and Omeprazole in Capsule Dosage Form by Simultaneous Equation and Absorbance Ratio Method.

Author(s): Varsha Balkrishna Mane, Surekha Babar, Karishma Waghmare, Anita S. Kulkarni

Email(s): varsha.mane76@gmail.com , varshu_mane@rediffmail.com

DOI: Not Available

Address: Varsha Balkrishna Mane*, Surekha Babar, Karishma Waghmare and Anita S. Kulkarni
Government College of Pharmacy, Vidyanagar, Karad (MS)
*Corresponding Author

Published In: Volume - 4, Issue - 7, Year - 2011

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ABSTRACT:
A versatile, accurate, precise and economic method for simultaneous determination of Domperidone and Omeprazole in fixed dose combination products was developed. The absorbance values at 284.8 nm and 301.2 nm and 290.9nm (isoabsorptive point) were used for the estimation of Domperidone and Omeprazole, respectively without mutual interference. This method obeyed Beer’s law in the concentration range of 18–28 µg /ml for Domperidone and 5-30 µg/ml for Omeprazole. The results of analyses have been validated statistically for linearity, accuracy and precision, LOD and LOQ of the proposed method.

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Cite this article:
Varsha Balkrishna Mane, Surekha Babar, Karishma Waghmare, Anita S. Kulkarni. Development of UV Spectrophotometric Method for the Simultaneous Estimation of Domperidone and Omeprazole in Capsule Dosage Form by Simultaneous Equation and Absorbance Ratio Method. Asian J. Research Chem. 4(7): July, 2011; Page 1119-1124.

Cite(Electronic):
Varsha Balkrishna Mane, Surekha Babar, Karishma Waghmare, Anita S. Kulkarni. Development of UV Spectrophotometric Method for the Simultaneous Estimation of Domperidone and Omeprazole in Capsule Dosage Form by Simultaneous Equation and Absorbance Ratio Method. Asian J. Research Chem. 4(7): July, 2011; Page 1119-1124. Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2011-4-7-20

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