Author(s):
Yougoubo Abdoulaye, Dabiré Constantin M., Sore Harouna, Bationo K. Remy, Ganame Arouna, Sawadogo Assétou, Roamba Noëlle Edwige, Bazié Benjamin, Kabore S. Dominique, Koala Moumouni, Palé Eloi, Nebie C. H. Roger, Nacro Mouhoussine
Email(s):
yougabdou@gmail.com
DOI:
10.52711/0974-4150.2024.00006 
Address:
Yougoubo Abdoulaye1*, Dabiré Constantin M.1,2, Sore Harouna3, Bationo K. Remy1,4, Ganame Arouna1, Sawadogo Assétou5, Roamba Noëlle Edwige6, Bazié Benjamin1, Kabore S. Dominique1, Koala Moumouni1,7, Palé Eloi1, Nebie C. H. Roger4, Nacro Mouhoussine1
1Laboratoire de Chimie Organique et de Physique appliquées. Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.
2Laboratoire de Chimie et Energies Renouvelables,
Université Nazi BONI. 01 BP 1091. Bobo-Dioulasso 01, Burkina Faso.
3Centre National de Recherche et de Formation sur le Paludisme (CNRFP)
01 BP 2208 Ouagadougou 01, Burkina Faso.
4Institut de Recherche en Sciences Appliquées et Technologies (IRSAT), Centre National de la Recherche Scientifique et Technique (CNRST) 03 BP 7023 Ouagadougou 03, Burkina Faso.
5Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales,
Université Nazi BONI. 01 BP 1091. Bobo-Dioulasso 01, Burkina Faso.
6Laboratoire de Biochimie. Biotechnologie, Techn
Published In:
Volume - 17,
Issue - 1,
Year - 2024
ABSTRACT:
Effective management of malaria remains a major concern for the scientific community mainly due to the resistance of Plasmodium falciparum to the common antimalarials. Many studies are conducted to identify plants that can fight against this disease. This work aimed to contribute to a better knowledge of antiplasmodial activity of different parts of Grangea maderaspatana (Asteracea). Thus, roots, flowers, leafy branches and whole plant of Grangea maderaspatana were extracted with hexane, dichloromethane, ethyl acetate and methanol. Alkaloid contents and antiplasmodial activity of extracts were respectively determined by bromocresol green method and enzyme-linked immunosorbent assay based on pLDH quantification. Total alkaloid contents ranged from 21.036 in methanolic extract of leafy branches to 1074.752µg qE/g in dichloromethane extract of whole plant. Extracts showed moderate to very active antiplasmodial effects. Antiplasmodial activity evaluated on chloroquino (CQ)-sensitive D10 and CQ-resistant Dd2 strains of Plasmodium falciparum showed that hexane and dichloromethane leafy branches extracts had a better activity. Alkaloid could be potentially responsible for antiplasmodial activity observed. None extract found to be toxic for cells at 50 and 100µg/ml. Dichloromethane extract of leafy branches could be a potential source of antiplasmodial molecules.
Cite this article:
Yougoubo Abdoulaye, Dabiré Constantin M., Sore Harouna, Bationo K. Remy, Ganame Arouna, Sawadogo Assétou, Roamba Noëlle Edwige, Bazié Benjamin, Kabore S. Dominique, Koala Moumouni, Palé Eloi, Nebie C. H. Roger, Nacro Mouhoussine. Total Alkaloid content and In vitro Antiplasmodial activity of Grangea maderaspatana collected from Burkina Faso. Asian Journal of Research in Chemistry. 2024; 17(1):31-6. doi: 10.52711/0974-4150.2024.00006
Cite(Electronic):
Yougoubo Abdoulaye, Dabiré Constantin M., Sore Harouna, Bationo K. Remy, Ganame Arouna, Sawadogo Assétou, Roamba Noëlle Edwige, Bazié Benjamin, Kabore S. Dominique, Koala Moumouni, Palé Eloi, Nebie C. H. Roger, Nacro Mouhoussine. Total Alkaloid content and In vitro Antiplasmodial activity of Grangea maderaspatana collected from Burkina Faso. Asian Journal of Research in Chemistry. 2024; 17(1):31-6. doi: 10.52711/0974-4150.2024.00006 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2024-17-1-6
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