ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Diwyani Gade, Abhijit Meshram, Darshika Nagrecha, Yashwant Jadhav, Prerana Pawar

Email(s): yashwantofficials04@gmail.com , diwyanigade@gmail.com , abhijitmeshram04@gmail.com

DOI: 10.52711/0974-4150.2024.00032   

Address: Diwyani Gade1, Abhijit Meshram2, Darshika Nagrecha3, Yashwant Jadhav4, Prerana Pawar5
1Katamla Post Uttamsara Taluka, District Amravati - 444602, Maharashtra, India.
2Pach Banglo, Old Town, Badnera, Dist Amravati - 444701, Maharashtra, India.
3Old Town Baripura Square, Badnera, Amravati Pin Code: 444701, Maharashtra, India.
4Subhash Chowk New Town, Badnera, Pin Code - 444701, Maharashtra, India.
5At Post Fulaamla District Amravati Sub District Nandgaon, Khandeshwar - 444701, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 3,     Year - 2024


ABSTRACT:
The study of the mechanisms of the effect of various food additives on the human and animal organism is one of the most pressing problems today. physicians, toxicologists, physiologists are aimed at studying the mechanisms of the toxic effect of food additives, as well as studying reactions in response to their ingestion. Monosodium glutamate intentionally added to food in order to keep certain properties or to extend shelf life of the food and to enhance the flavors of it. it is the most common food additive which is used in various countries. Monosodium glutamate is made up of nutritionally indispensable amino acids. This study is aimed to shed light on the available research, which had been carried out on animal and human models regarding possible effects of monosodium glutamate. This review showed that monosodium glutamate was associated with adverse side-effects on various systems of human body like obesity, diabetes, hepatotoxic, neurotoxic and genotoxic effects. Available review showed that increased consumption of monosodium glutamate may be associated with harmful health effects.


Cite this article:
Diwyani Gade, Abhijit Meshram, Darshika Nagrecha, Yashwant Jadhav, Prerana Pawar. Inimical effects of Monosodium Glutamate on various systems. Asian Journal of Research in Chemistry. 2024; 17(3):174-8. doi: 10.52711/0974-4150.2024.00032

Cite(Electronic):
Diwyani Gade, Abhijit Meshram, Darshika Nagrecha, Yashwant Jadhav, Prerana Pawar. Inimical effects of Monosodium Glutamate on various systems. Asian Journal of Research in Chemistry. 2024; 17(3):174-8. doi: 10.52711/0974-4150.2024.00032   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2024-17-3-9


REFERENCES:
1.    PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 23676143, Monosodium L-glutamate; [cited 2023 Oct. 2]. Available from: https:// pubchem.ncbi.nlm.nih.gov/compound/Monosodium-L-glutamate
2.    Mahfoudh A.M. Abdulghani, Salah Abdulrazak AL Shehade, Sareh Kamran, Mohammed Abdullah Alshawsh, Effect of monosodium glutamate on serum sex hormones and uterine histology in female rats along with its molecular docking and in-silico toxicity, Heliyon. 2022; 8(10): e10967 https://doi.org/10.1016/ j.heliyon.2022.e10967. (https://www.sciencedirect.com/science/ article/pii/S2405844022022551)
3.    Wikipedia contributors. Monosodium glutamate. Wikipedia, The Free Encyclopedia. Wikipedia, The Free Encyclopedia, 21 Sep. 2023. Web. 2 Oct. 2023.
4.    Niaz K, Zaplatic E, Spoor J. Extensive use of monosodium glutamate: A threat to public health? Excli J. 2018; 17: 273-278. doi: 10.17179/excli2018-1092.  
5.    Zehra Kazmi, Iffat Fatima, Shaghufta Perveen and Saima Shakil Malik. Monosodium glutamate: Review on clinical reports. International Journal of Food Properties. 2017; 20(Sup2): 1807-1815. DOI: 10.1080/10942912.2017.1295260
6.    https://www.spglobal.com/commodityinsights/en/ci/products/monosodium-glutamate-chemical-economics-handbook.html
7.    Nazmiye Ataseven, Deniz Yüzbaşıoğlu, Ayten Çelebi Keskin, Fatma Ünal, Genotoxicity of monosodium glutamate, Food and Chemical Toxicology. 2016; 91: 8-18.  https://doi.org/10.1016/j.fct.2016.02.021. (https:// www.sciencedirect.com/science/article/pii/S0278691516300540)
8.    Kayode OT, Rotimi DE, Kayode AAA, Olaolu TD, Adeyemi OS. Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review. Toxics. 2020; 8(1): 7. doi: 10.3390/ toxics8010007.
9.    Oladipo, I. C., E. A. Adebayo, and O. M. Kuye. Effects of monosodium glutamate in ovaries of female Sprague-Dawley rats. Int J Curr Microbiol App Sci. 2015; 4(5): 737-745.
10.    Shosha HM, Ebaid HM, Toraih EA, Abdelrazek HMA, Elrayess RA. Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats. Environ Sci Pollut Res Int. 2023; 30(17): 49779-49797. doi: 10.1007/s11356-023-25661-x.
11.    Arnab Banerjee, Sandip Mukherjee, Bithin Kumar Maji. Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview. Toxicology Reports. 2021; 8: 938-961 https://doi.org/10.1016/j.toxrep.2021.04.009. (https://www.sciencedirect.com/science/article/pii/S2214750021000858)
12.    https://www.linkedin.com/pulse/functional-neurology-msg-neurological-diseases-jimenez-
13.    https://www.healthkart.com/connect/monosodium-glutamate/
14.    Falalieieva TM, Kukhars'kyĭ VM, Berehova TV. [Effect of long-term monosodium glutamate administration on structure and functional state of the stomach and body weight in rats]. Fiziol Zh (1994). 2010; 56(4): 102-10. Ukrainian. PMID: 20968043.
15.    Jinzhao Xu, Mengqi Tang, Yini Liu, Jinghan Xu, Xiaoxi Xu, Safety assessment of monosodium glutamate based on intestinal function and flora in mice, Food Science and Human Wellness, 2022; 11(1): 155164 https://doi.org/10.1016/ j.fshw.2021.07.016. (https://www.sciencedirect.com/science/ article/pii/S2213453021000823)
16.    Das D, Banerjee A, Bhattacharjee A, Mukherjee S, Maji BK. Dietary food additive monosodium glutamate with or without high-lipid diet induces spleen anomaly: A mechanistic approach on rat model. Open Life Sci. 2022; 17(1): 22-31. doi: 10.1515/biol-2022-0004.  
17.    Hazzaa SM, El-Roghy ES, Abd Eldaim MA, Elgarawany GE. Monosodium glutamate induces cardiac toxicity via oxidative stress, fibrosis, and P53 proapoptotic protein expression in rats. Environ Sci Pollut Res Int. 2020; 27(16): 20014-20024. doi: 10.1007/s11356-020-08436-6.  
18.    Maeve Shannon, Brian Green, Gary Willars, Jodie Wilson, Natalie Matthews, Joanna Lamb, Anna Gillespie, Lisa Connolly The endocrine disrupting potential of monosodium glutamate (MSG) on secretion of the glucagon-like peptide-1 (GLP-1) gut hormone and GLP-1 receptor interaction, Toxicology Letters. 2017; 265: 97-105 https://doi.org/10.1016/ j.toxlet.2016.11.015. (https://www.sciencedirect.com/science/ article/pii/S037842741633315X)
19.    T.W. Redding, A.V. Schally, A. Arimura, I. Wakabayashi; Effect of Monosodium Glutamate on Some Endocrine Functions. Neuroendocrinology. 1971; 8(3-4): 245–255. https:// doi.org/10.1159/000122011
20.    Arup Datta, Aslam Hossain, Sanjay Roy. An Overview on Monosodium Glutamate: Its direct and indirect effects. Research J. Pharm. and Tech. 2019; 12(12): 6187-6192.
21.    Nasser Hadal Alotaibi, Abdulaziz I. Alzarea, Nabeel K. Alruwaili, Dibya sundar panda, Mohamed A. Abdulwahab, Mohammed Gamal, Mohemed M. El Sanea, Ehab M. Mostafa, Mohamed M. Rowezak. Awareness among Saudi Arabian parents of the relationship between Monosodium Glutamate intake and increasing Body Weight. Research Journal of Pharmacy and Technology. 2021; 14(10): 5270-3.
22.    Cite:Inshah Ahmed, Nishat Ahmed, Saleha Ahmed, Fazil Ahmad, Abeer Mohammed Al-Subaie. Effect of Emblica officinalis (Amla) on Monosodium Glutamate (MSG) Induced Uterine Fibroids in Wistar Rats. Research J. Pharm. and Tech. 2020; 13(6): 2535-2539.
23.    Pingle Shubhangi, Patil Mandakini, Duragkar Nandkishore, Bhongade Subhash, Nimbekar Tulsidas, Katolkar Parimal. Antifertility Activity of Ficus bengalensis Linn: Special Emphasis on Histoarchitecture Changes of Female Reproductive System of Rat. Research J. Pharm. and Tech.  2010; 3(4): 1285-1287.
24.    Santhosh Kumar R, Asha Devi. S. Lead Toxicity on Male Reproductive System and its Mechanism: A Review. Research J. Pharm. and Tech. 2018; 11(3): 1228-1232.
25.    Dattaprasad N. Vikhe. Ten food that boost Immune System: A Review. Research Journal of Science and Technology. 2021; 13(4): 244-2.
26.    Manoj K. Baladaniya, Ankit P. Karkar, Nirav V. Patel. Review on Drug Delivery to the Central Nervous System: Novel Approaches. Res. J. Pharm. Dosage Form. and Tech. 2014; 6(4): 253-266.
27.    M. V. Dementyev, S.M Chibisov, M. V. Abramova, S.D. Beeharry, M.L. Blagonravov, S.P. Syatkin, E.V. Neborak, I.P. Smirnova, G.I. Myandina, V.I. Kuznetsov. Study of Criteria of Cardiovascular System Desynchronization in Locomotive Drivers’ Brigade in Russia. Research J. Pharm. and Tech. 2017; 10(3): 891-895.
28.    Arup Datta, Aslam Hossain, Sanjay Roy. An Overview on Monosodium Glutamate: Its direct and indirect effects. Research J. Pharm. and Tech. 2019; 12(12): 6187-6192.
29.    Pingle Shubhangi, Patil Mandakini, Duragkar Nandkishore, Bhongade Subhash, Nimbekar Tulsidas, Katolkar Parimal. Antifertility Activity of Ficus bengalensis Linn: Special Emphasis on Histoarchitecture Changes of Female Reproductive System of Rat. Research J. Pharm. and Tech. 2010; 3(4): 1285-1287.
30.    Sukhbir Lal Khokra, Bharat Parashar, Hitesh Kumar Dhamija, Manju Bala. Immunomodulators: Immune System Modifiers. Research J. Pharm. and Tech. 2012; 5(2): 169-174.

Recomonded Articles:

Author(s): C.Balamurugan, L. Leena Hebsibai

DOI:         Access: Open Access Read More

Author(s): Kadhiravansivasamy, S. Sivajiganesan, T. Periyathambi, V. Nandhakumar, M. Pugazhenthi

DOI: 10.5958/0974-4150.2017.00016.5         Access: Open Access Read More

Author(s): Gopalasatheeskumar K, Ariharasiva Kumar G, Sengottuvel T, Sanish Devan V, Srividhya V

DOI: 10.5958/0974-4150.2019.00062.2         Access: Open Access Read More

Author(s): Anitha Jebamalai Raj, Sudarsanam Dorairaj

DOI:         Access: Open Access Read More

Author(s): Maqdoom Farooqui, Syed Nazimuddin

DOI: 10.5958/0974-4150.2017.00026.8         Access: Open Access Read More

Author(s): Jeevan Jyoti Mohindru, Umesh Kumar Garg, Rajni Gupta

DOI: 10.5958/0974-4150.2017.00069.4         Access: Open Access Read More

Author(s): M. Maheswarlu, L. Anitha, K.V. Sucharitha, M. Leelavathi

DOI:         Access: Open Access Read More

Author(s): Avanti K. Galande, Sachin H. Rohane

DOI: 10.5958/0974-4150.2021.00017.1         Access: Open Access Read More

Author(s): M. Govindammal, M. Prasath, B. Sathya, M. Selvapandiyan

DOI: 10.5958/0974-4150.2017.00079.7         Access: Open Access Read More

Author(s): Lingappa Mallesha, Guruswamy Vinay, Bantal Veeresh

DOI: 10.5958/0974-4150.2018.00053.6         Access: Open Access Read More

Author(s): Y. A. Jaliwala,Rahul Chaturvedi, Arvind Rathore, Amit Pandit, P.K. Mohanty

DOI:         Access: Open Access Read More

Author(s): Venkata Subba Rao Mushini, Ananta Ramam Veluri, Muralidhara Rao Volety

DOI:         Access: Open Access Read More

Author(s): A. J.Chinweuba, I. E. Otuokere, M.C. Opara, G.U. Okafor

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags