ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Souvik Sur

Email(s): drsouvik.engineering@tmu.ac.in

DOI: 10.52711/0974-4150.2024.00016   

Address: Souvik Sur*
Research and Development Center, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh - 244001, India.
*Corresponding Author

Published In:   Volume - 17,      Issue - 2,     Year - 2024


ABSTRACT:
This study introduces a versatile method for coupling single-stranded DNA with small heterocyclic compounds, leveraging the reactivity of amino and carboxylic functional groups. By employing COMU and Collidine, BNIMZ and BNTZA were successfully coupled with poly-T DNA. The conjugation technique was successfully confirmed by high accuracy MALDI-TOF MS. This approach offers a reliable and efficient strategy for constructing DNA-conjugates with tailored properties.


Cite this article:
Souvik Sur. Coupling of Single-Stranded poly-T DNA with Small Heterocyclic compounds via Peptide Linkage. Asian Journal of Research in Chemistry. 2024; 17(2):81-4. doi: 10.52711/0974-4150.2024.00016

Cite(Electronic):
Souvik Sur. Coupling of Single-Stranded poly-T DNA with Small Heterocyclic compounds via Peptide Linkage. Asian Journal of Research in Chemistry. 2024; 17(2):81-4. doi: 10.52711/0974-4150.2024.00016   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2024-17-2-4


REFERENCES:
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3.    Van Berkel, S. S., Van Eldijk, M. B., and Van Hest, J. C. Staudinger ligation as a method for bioconjugation. Angewandte Chemie International Edition, 2011; 50(38), 8806-8827. https://doi.org/10.1002/anie.201008102
4.    Almeida‐Pinto, J., Lagarto, M. R., Lavrador, P., Mano, J. F., and Gaspar, V. M. (2023). Cell Surface Engineering Tools for Programming Living Assemblies. Advanced Science, 10(34), 2304040. https://doi.org/10.1002/advs.202304040
5.    Wang, Z. G., and Ding, B. DNA-templated self-assembly of functional nanostructures. Chemical Reviews, 2018; 118(17), 8045-8087. https://doi.org/10.1002/adma.201301450
6.    Fay, R., and Holland, J. P. The impact of emerging bioconjugation chemistries on radiopharmaceuticals. Journal of Nuclear Medicine, 2019; 60(5), 587-591. https://doi.org/10.2967/jnumed.118.220806
7.    Benizri, S., Gissot, A., Martin, A., Vialet, B., Grinstaff, M. W., and Barthélémy, P. Bioconjugated oligonucleotides: recent developments and therapeutic applications. Bioconjugate chemistry, 02019; 30(2), 366-383. https://doi.org/10.1021/acs.bioconjchem.8b00761
8.    Sur, S., and Khan, U. Compatibility of benzimidazole and benzothiazole derivatives towards poly-A. poly-T DNA. Indian Journal of Chemistry, 2024; 63, 65-71. https://doi.org/10.56042/ijc.v63i1.3936
9.    Pandey, S., Sur, S., and Tandon, V. Substituent specific bisbenzimidazole binding towards AT-rich DNA. J. Indian Chem. Soc, 2018; 95, 1607-1616.
10.    Rbaa, M., Abousalem, A. S., Galai, M., Lgaz, H., Lakhrissi, B., Warad, I., and Zarrouk, A. New N-heterocyclic compounds based on 8-hydroxyquinoline as efficient corrosion inhibition for mild steel in hcl solution: experimental and theoretical assessments. Arabian Journal for Science and Engineering, 2021; 46, 257-274. https://doi.org/10.1007/s13369-020-04667-4
11.    El-Meguid, E. A. A., and Ali, M. M. Synthesis of some novel 4-benzothiazol-2-yl-benzoyl-1 H-pyrazoles, and evaluation as antiangiogenic agents. Research on Chemical Intermediates, 2016; 42, 1521-1536. https://doi.org/10.1007/s11164-015-2100-8
12.    El‐Faham, A., and Albericio, F. COMU: a third generation of uronium‐type coupling reagents. Journal of peptide science: an official publication of the European Peptide Society, 2010; 16(1), 6-9. https://doi.org/10.1002/psc.1204


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