ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Pratap Y. Pawar, Kunal N. Jangale

Email(s): pypawar2009@rediffmail.com

DOI: Not Available

Address: Pratap Y. Pawar, Kunal N. Jangale
P.D.V.V.P.F’s College of Pharmacy, Vilad Ghat, Ahmednagar, 414 111, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 11,     Year - 2011


ABSTRACT:
In these study, a series of N2-substituted Dihydrophthalazine-1,4-dione Derivatives (2a-2o) were synthesized from phthalic anhydride and aromatic acid hydrazides (1a-1o) using microwave irradiation. The synthesized compounds were confirmed by IR and1H NMR studies. Synthesized compounds were evaluated for anticonvulsant activity by using maximal electroshock (MES) method. Neurologic deficit was evaluated by the rotarod test. All the compounds exhibited significant anticonvulsant activity. Compounds 2a, 2b, 2i and 2o were most active of the series against MES-induced seizures.


Cite this article:
Pratap Y. Pawar, Kunal N. Jangale. Microwave Assisted Synthesis and Pharmacological Evaluation of N2-substituted Dihydrophthalazine-1,4-dione Derivatives. Asian J. Research Chem. 4(11): Nov., 2011; Page 1722-1725.

Cite(Electronic):
Pratap Y. Pawar, Kunal N. Jangale. Microwave Assisted Synthesis and Pharmacological Evaluation of N2-substituted Dihydrophthalazine-1,4-dione Derivatives. Asian J. Research Chem. 4(11): Nov., 2011; Page 1722-1725.   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2011-4-11-14


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DOI: 10.5958/0974-4150 

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