Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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In vitro Interaction of Fexofenadine with H2 Receptor Antagonist

Author(s): Hina Shahnaz, M. Saeed Arayne, Najma Sultana, Amir Haider

Email(s): hinashehnaz@gmail.com

DOI: Not Available

Address: Hina Shahnaz1*, M. Saeed Arayne2, Najma Sultana2 and Amir Haider2
1Department of Chemistry, University of Karachi, Karachi.
2Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi.
*Corresponding Author

Published In:   Volume - 5,      Issue - 5,     Year - 2012

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ABSTRACT:
Fexofenadine is a second generation H1-receptor antagonist, much widely used due to its non-sedative effects. The in vitro availability of fexofenadine in the presence of H2-receptor antagonist (cimetidine, ranitidine and famotidine) was studied on a BP 2005 dissolution test apparatus to observe the kinetics and energies of fexofenadine in the presence of H2-receptor antagonist (cimetidine, ranitidine and famotidine). These studies were carried out in buffers of pH 2, 4 (simulated gastric juice), 7.4 (blood pH) and 9 (simulated intestinal juice) at 37°C and at elevated temperatures. These studies showed that all H2-receptor antagonist (cimetidine, ranitidine and famotidine) interact to fexofenadine. Moreover, these interactions were not temperature dependent but pH dependent.


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Cite this article:
Hina Shahnaz, M. Saeed Arayne, Najma Sultana, Amir Haider. In vitro Interaction of Fexofenadine with H2 Receptor Antagonist. Asian J. Research Chem. 5(5): May 2012; Page 668-677.

Cite(Electronic):
Hina Shahnaz, M. Saeed Arayne, Najma Sultana, Amir Haider. In vitro Interaction of Fexofenadine with H2 Receptor Antagonist. Asian J. Research Chem. 5(5): May 2012; Page 668-677.   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2012-5-5-21


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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