ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Monica Arora, J. Saravanan, S. Mohan, Shivaji Bhattacharjee

Email(s): monicaarora15@gmail.com

DOI: Not Available

Address: Monica Arora*, J. Saravanan, S. Mohan, Shivaji Bhattacharjee
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 1,     Year - 2013


ABSTRACT:
2-amino-4-(4-chlorophenyl)-N-(3-furan-2-ylmethyl carboxamido) thiophenes was synthesized using versatile Gewald reaction .First step is preparation of furfuryl cyanoacetamide which was carried out by condensation of furfuryl amine and ethyl cyano acetate which was then reacted with p-chloro acetophenone, sulphur, diethyl amine to give 2-amino-4-(4-chlorophenyl)-N-(3-furan-2-yl methyl carboxamido) thiophene (SM-4) later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases(SM 4a-4l). The compounds were characterized IR, 1H NMR and mass spectral data and screened for antimicrobial activity.


Cite this article:
Monica Arora, J. Saravanan, S. Mohan, Shivaji Bhattacharjee. Synthesis, Characterization and Antimicrobial Activity of Some Schiff Bases of 2-amino-4-(4-chlorophenyl)–n-(3-furan-2-ylmethyl carboxamido) thiophenes. Asian J. Research Chem. 6(1): January 2013; Page 24-28.

Cite(Electronic):
Monica Arora, J. Saravanan, S. Mohan, Shivaji Bhattacharjee. Synthesis, Characterization and Antimicrobial Activity of Some Schiff Bases of 2-amino-4-(4-chlorophenyl)–n-(3-furan-2-ylmethyl carboxamido) thiophenes. Asian J. Research Chem. 6(1): January 2013; Page 24-28.   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2013-6-1-7


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