Asian Journal of Research in Chemistry

ISSN

0974-4150 (Online)
0974-4169 (Print)


Submit Article

Synthesis and In Vitro Anti-inflammatory Activity of Some 1- [(2- (Methylsulphonyl amino) thiazole-4-yl) methyl]-3- aryl thioureas.

Author(s): Rahul A. Waghmare

Email(s): rahulwaghmare100@gmail.com

DOI: 10.5958/0974-4150.2017.00077.3   

Address: Rahul A. Waghmare*
Department of Chemistry, Milind College of Science, Nagsenvana, Aurangabad- 431 002.
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2017

 View HTML        View PDF

ABSTRACT:
New thioureas (4a-f) bearing 2-methylsulhonyl amino thiazol-4-methyl moiety have been synthesized by multistep synthesis depicted in Scheme.1. Intermediate 2-Amino-4-(isothiocynatomethyl) thiazole (2) has been synthesized from 2-amino-4-chloromethyl thiazole hydrochloride (1) by nucleophilic displacement of chlorine by isothiocynate. The compound (2) on subsequent condensation with methyl sulphonyl chloride carried in the presence of triethyl amine in DCM yielded 2-methylsulphonyl amino-4-(isothiocynatomethyl) thiazole (3) which on addition with aryl amines in refluxed pyridine gave the titled thioueras. Synthesized intermediates and final compounds were characterized by I.R, 1H NMR, MASS spectroscopic techniques and C, H, N and S analysis. Synthesized final compounds were evaluated for in vitro anti-inflammatory activity by HRBC membrane stabilization method. Most of the synthesized compound exhibited good anti-inflammatory activity as compared to standard Diclofenac sodium.


Keywords:

Cite this article:
Rahul A. Waghmare. Synthesis and In Vitro Anti-inflammatory Activity of Some 1- [(2- (Methylsulphonyl amino) thiazole-4-yl) methyl]-3- aryl thioureas. Asian J. Research Chem. 2017; 10(4):477-482. doi: 10.5958/0974-4150.2017.00077.3

Cite(Electronic):
Rahul A. Waghmare. Synthesis and In Vitro Anti-inflammatory Activity of Some 1- [(2- (Methylsulphonyl amino) thiazole-4-yl) methyl]-3- aryl thioureas. Asian J. Research Chem. 2017; 10(4):477-482. doi: 10.5958/0974-4150.2017.00077.3   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2017-10-4-8


Recomonded Articles:

Pyridine and Its Biological Activity: A Review

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Synthesis, Characterisation, DNA binding/cleavage, anticancer and antimicrobial activity of Ternary Copper(II) Complexes

Author(s): S. Dhakshanamoorthy, M. Murali Krishnan, M.N. Arumugham

DOI: 10.5958/0974-4150.2017.00052.9         Access: Open Access Read More

Herbal tea for the treatment of Urinary diseases as Potent diuretic and Anti-inflammatory agent

Author(s): Kateryna Taran, Ayaou Abderrahim, Vera Kravchenko, Olena Novosel, Svitlana Taran

DOI: 10.5958/0974-4150.2020.00034.6         Access: Open Access Read More

A Short Review on Structures and Synthesis of some Heterocyclic Compounds

Author(s): Azam Z. Shaikh, Harsha Jadhav, Darshana M. Borse, Ritik. S. Jain

DOI: 10.5958/0974-4150.2021.00028.6         Access: Open Access Read More

Synthesis and antimicrobial evaluation of Azetidinone derivatives of pyridine containing hydrazides

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Phytochemical, Pharmacological and Therapeutic Potential of Hordeum vulgare Linn. - A Review

Author(s): Anshul Sinha, A. K. Meena, P. Panda, Bhavana Srivastava, M. D. Gupta, M. M. Padhi

DOI:         Access: Open Access Read More

Analytical Methods of Dihydropyridines Based Calcium Channel Blockers - Amlodipine, Lacidipine, Isradipine, Nifedipine, Felodipine, Cilnidipine and its related formulations: A Review

Author(s): Pankaj Kisan Chatki, Sana Tabassum

DOI: 10.52711/0974-4150.2021.00039         Access: Open Access Read More

Synthesis and Biological Activities of Some Benzothiazole Derivatives

Author(s): Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S

DOI:         Access: Open Access Read More

Synthesis, characterization and anti-inflammatory activity some 1-(4-substituted)-2-(-4-(piperazine-1-yl) bis-thiazole-5-yl) 2-methyl-4-nitro-1h-imidazole-1-yl) ethanone

Author(s): Aejaz Ahmed, Khurshid I. Molvi, Gulam Javed Khan

DOI: 10.5958/0974-4150.2017.00027.X         Access: Open Access Read More

A Review on Pyranocoumarins and its biological importance

Author(s): K.P. Beena, G. Sathya Pooja

DOI: 10.52711/0974-4150.2022.00030         Access: Open Access Read More

Synthesis and Biological Evaluation of Some Substituted Amino Thiazole Derivatives

Author(s): SR Pattan, NS Dighe, SA Nirmal, AN Merekar, RB Laware, HV Shinde, DS Musmade

DOI:         Access: Open Access Read More

Critical review: Significance of Force degradation study with respect to current Pharmaceutical Scenario

Author(s): Nikita N. Patel, Charmy S. Kothari

DOI:         Access: Open Access Read More

Oxindoles and Their Pharmaceutical Significance- An Overview

Author(s): Shashi Ravi Suman Rudrangi, Vijaya Kumar Bontha, Venkata Reddy Manda, Srinivas Bethi

DOI:         Access: Open Access Read More

Synthesis and In Vitro Antimicrobial Activity of Some New 4-Amino-N-(1,3- Benzothiazol-2-yl) benzenesulphonamide Derivatives

Author(s): KP Bhusari, ND Amnerkar, PB Khedekar, MK Kale, RP Bhole

DOI:         Access: Open Access Read More

Strategies for the Synthesis and Biological Screening of Thiazolidinone Derivatives

Author(s): Pankaj Baboo, Girendra Gautam, S.K. Gupta

DOI: 10.5958/0974-4150.2017.00039.6         Access: Open Access Read More

Drug Designing in Discovery Studio

Author(s): Bhagyashree L. Jejurikar, Sachin H. Rohane

DOI: 10.5958/0974-4150.2021.00025.0         Access: Open Access Read More

Simultaneous Estimation of Atorvastatin, Clopidogrel and Aspirin in Capsule Dosage forms using UV-Spectroscopy

Author(s): Sunil Singh, Nitin Dubey, D.K. Jain

DOI:         Access: Open Access Read More

Novel Curcumin Derivatives: Targeted for Anti-Inflammatory Activity

Author(s): Sabale Prafulla, Potey Lata, Rahangdale Priya, Sabale Vidya

DOI: 10.5958/0974-4150.2019.00011.7         Access: Open Access Read More

Recent development in synthesis and biological application of organotin complexes

Author(s): Nitesh Jaiswal, Raj Kuamr Dubey

DOI: 10.5958/0974-4150.2017.00072.4         Access: Open Access Read More

Design, molecular docking studies of oxaprozin linked to 4-thiazolidinone derivatives as a potent anticancer, analgesic and antiinflammatory agents

Author(s): Kishore Kumar Valluri, Tejeswara Rao Allaka, I V Kasi Viswanath, Nagaraju PVVS

DOI: 10.5958/0974-4150.2018.00111.6         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Quick Links

Latest Issues

Popular Articles


Recent Articles



Aminothiophene and Schiff base derivative-synthesis, Density Functional theory, ADME study and it’s characterization
A Review of Imidazole Derivatives: Synthesis, Pharmacological Applications, and Future Perspectives
Lavender Oil: A Comprehensive Review of Composition and Applications
The Environmental and Biological Risks of Micro and Nano Plastics: A Review
Polymer-Based Hydrogels as Enhanced Drug Delivery System
Method Development and Validation of Thymol from Trachyspermum ammi using HPLC (High Performance Liquid Chromatography)
Carotenoid profiling by HPLC-MS/MS of Mung bean (Vigna radiata (L) R. Wilczek 1854), acclimated to Burkina Faso
Analysis of K and Na content of Soil samples by Flame Emission Photometry with other parameters
A Novel Stability Indicating Analytical Development and Validation of an RP-HPLC Assay Method for the Quantification of Voglibose in Bulk and its Formulation
Determination of Emtricitabine from Pharmaceutical Dosage Form By extractive ion pair complex colorimetric method
RP-HPLC Method Development and Validation for Simultaneous Estimation of Pravastatin and Bempedoic acid in Bulk and Pharmaceutical Formulation
Determination of Sodium and Potassium in Groundwater (Borewell) Samples of Baglan Region of Maharashtra by Flame Photometry
Synthesis, Characterization and Antimicrobial Studies of Transition Metal Complexes with Triazine-5-hydrazones of o-anisaldehyde
Simultaneous Quantification of Berberine and Curcumin in Combined Extract Form and Polyherbal Marketed Formulation
Air Pollution: Health Impact and Control
Synthesis, and Evaluation of Novel N-(5-cyano-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4-yl)-2-(phenylamino) acetamide derivatives by In silico investigations as an anticancer scaffold
Analysis of traces of the transferred paints by X-ray Fluorescence and UV-Vis spectroscopy to identify the suspect
Biological Activity of Substituted Benzothiazoles
Importance of GC-MS for Analyzing Sars-Cov-2 Drugs in Biological Sample
Review on Drugs Acting on Candida Infection and Their Treatment

Tags


About Journal

Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
Read More  

Visitors

Today: 67
Yesterday: 1453
Total: 1714776