ABSTRACT:
A sensitive non-aqueous potentiometric titration method was developed for quantitative determination of secnidazole from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2> 0.999) between 20 % to 100 % of 500 mg of drug substance weight. The percentage recovery of secnidazole in the optimized method was between 99.643 to 100.505 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
Cite this article:
Rajan V. Rele. A non-Aqueous Potentiometric Titration Method for Validation of Secnidazole from Pharmaceutical Dosages. Asian J. Research Chem. 2019; 12(1): 25-28. doi: 10.5958/0974-4150.2019.00006.3
Cite(Electronic):
Rajan V. Rele. A non-Aqueous Potentiometric Titration Method for Validation of Secnidazole from Pharmaceutical Dosages. Asian J. Research Chem. 2019; 12(1): 25-28. doi: 10.5958/0974-4150.2019.00006.3 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2019-12-1-6