A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of molnupiravir from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 10 % to 50 % w/v of 100 mg of drug substance weight. The percentage recovery of molnupiravir in the optimized method was between 99.05 to 99.81 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
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Rele Rajan V., Tiwatane Prathamesh P.. A Validated Potentiometric Titration Method for Quantitative Determination of Molnupiravir from Pharmaceutical Preparation. Asian Journal of Research in Chemistry. 2022; 15(6):439-2. doi: 10.52711/0974-4150.2022.00077
Rele Rajan V., Tiwatane Prathamesh P.. A Validated Potentiometric Titration Method for Quantitative Determination of Molnupiravir from Pharmaceutical Preparation. Asian Journal of Research in Chemistry. 2022; 15(6):439-2. doi: 10.52711/0974-4150.2022.00077 Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2022-15-6-9
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