Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Synthesis and In Vitro Antibacterial Evaluations of Novel Amino-Pyrimidines

Author(s): Sarfraz Alam, Garima Avasthi

Email(s): alamsir@in.com

DOI: Not Available

Address: Md. Sarfraz Alam* and Garima Avasthi
Dept. of Pharmaceutical Chemistry, Babu Banarsi Das Institute of Technology and Management, Lucknow, UP
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010

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ABSTRACT:
A number of chalcones were synthesized by reacting 2-Acetyl Naphthalene, with Aryl substituted aldehydes in ethanolic NaOH, a Claisen-Schmidt condensation reaction. These chalcones were further reacted with guanidine nitrate in presence of ethanolic NaOH to obtain the amino pyrimidines. The synthesized compounds were characterized on the basis of physical ,chemical and spectroscopic data and were tested for the antibacterial activity using cup plate method. Evaluation of the compounds revealed remarkable antibacterial activity. In particular, amino-pyrimidines were found to be the most effective against Bacillus subtilis and Escherichia coli bacterial strains.


Keywords:

Cite this article:
Sarfraz Alam, Garima Avasthi . Synthesis and In Vitro Antibacterial Evaluations of Novel Amino-Pyrimidines. Asian J. Research Chem. 3(2): April- June 2010; Page 430-433.

Cite(Electronic):
Sarfraz Alam, Garima Avasthi . Synthesis and In Vitro Antibacterial Evaluations of Novel Amino-Pyrimidines. Asian J. Research Chem. 3(2): April- June 2010; Page 430-433.   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2010-3-2-46


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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