Asian Journal of Research in Chemistry

ISSN

0974-4150 (Online)
0974-4169 (Print)


Submit Article

Physiochemical Investigation and Role of Indicator Parameter in the Modeling of Tetrahydroimidazole Benzodiazepine -1- one (TIBO): A QSAR Study

Author(s): Lokendra Kumar Ojha, Ajay M Chaturvedi, Arpan Bhardwaj, Abhilash Thakur, Mamta Thakur

Email(s): ojha_lokendra@rediffmail.com

DOI: Not Available

Address: Lokendra Kumar Ojha*, Ajay M Chaturvedi*, Arpan Bhardwaj*, Abhilash Thakur1, Mamta Thakur2
*Department of Chemistry, Govt. Madhav Science PG College, Ujjain (MP), INDIA
Department of Applied Science, NITTTR, Bhopal (MP), INDIA
Department of Pharma. Chemistry, Softvision College, Indore (MP), INDIA
*Corresponding Author

Published In:   Volume - 5,      Issue - 3,     Year - 2012

 View HTML        View PDF

ABSTRACT:
The aim of the author in this paper is to emphasize the role of indicator parameter for TIBO 89 derivatives with the help of computational drug design. A QSAR study has been carried out to know the drug receptor binding affinity of the TIBO derivatives. In this regard multiple linear regression analysis (MLR) method has been used and different indicator parameter is used to obtain the better mathematical model in the particular set. The substitution at the –Z position on five member ring, –R position on seven member ring and –X position on benzene ring plays vital role in this concern. The statistical analysis multiple R= .9170, standard error of estimation (Se= .5572) and Fisher Ratio (F= 122.383) values gives the satisfactory explanation of the data set to know the effect of indicator parameter on the biological activity.


Keywords:

Cite this article:
Lokendra Kumar Ojha, Ajay M Chaturvedi, Arpan Bhardwaj, Abhilash Thakur, Mamta Thakur. Physiochemical Investigation and Role of Indicator Parameter in the Modeling of Tetrahydroimidazole Benzodiazepine -1- one (TIBO): A QSAR Study. Asian J. Research Chem. 5(3): March 2012; Page 377-382.

Cite(Electronic):
Lokendra Kumar Ojha, Ajay M Chaturvedi, Arpan Bhardwaj, Abhilash Thakur, Mamta Thakur. Physiochemical Investigation and Role of Indicator Parameter in the Modeling of Tetrahydroimidazole Benzodiazepine -1- one (TIBO): A QSAR Study. Asian J. Research Chem. 5(3): March 2012; Page 377-382.   Available on: https://www.ajrconline.org/AbstractView.aspx?PID=2012-5-3-13


Recomonded Articles:

Pyridine and Its Biological Activity: A Review

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Structural and Biological Activity Studies on Metal Complexes Containing Thiosemicarbzone and Isatin Based Schiff Base: A Review

Author(s): Saddam Hossain, C. M. Zakaria, Kudrat-E-Zahan

DOI: 10.5958/0974-4150.2017.00002.5         Access: Open Access Read More

Application of Chalcones in Synthesis of Novel 1, 5-Benzodiazepine Derivatives Containing Thieno [2, 3-d] Pyrimidine Core Unit and its Biological Activity Screening

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

A Review on Pyranocoumarins and its biological importance

Author(s): K.P. Beena, G. Sathya Pooja

DOI: 10.52711/0974-4150.2022.00030         Access: Open Access Read More

Oxindoles and Their Pharmaceutical Significance- An Overview

Author(s): Shashi Ravi Suman Rudrangi, Vijaya Kumar Bontha, Venkata Reddy Manda, Srinivas Bethi

DOI:         Access: Open Access Read More

Drug Designing in Discovery Studio

Author(s): Bhagyashree L. Jejurikar, Sachin H. Rohane

DOI: 10.5958/0974-4150.2021.00025.0         Access: Open Access Read More

A Concise Review on role of QSAR in Drug Design

Author(s): V. Prema, Meera Sivaramakrishnan, M. Rabiya

DOI: 10.52711/0974-4150.2023.00076         Access: Open Access Read More

Synthesis, characterization and pharmacological evaluation of novel spiro heterocyclic compounds as anti diabetic agents

Author(s): K. Kishore Kumar, R.S.K. Sharma, P. Chanti Babu, M. Sreenivasa Rao, K. Durga Prasadu, D. Ravi Kumar

DOI: 10.5958/0974-4150.2017.00067.0         Access: Open Access Read More

Facile One-Pot Synthesis, Characterization, and Biological Activity of 2-(5-(4-subsituted phenyl)-3-(4-subsituted phenyl)-4,5-dihydropyrazol-1-yl)-N-(5-(3-subsitutedphenyl)-1,3,4-thiadiazol-2-yl)acetamide Derivatives

Author(s): Parjanya Kumar Shukla, Amita Verma, Prateek Pathak, Pragya Mishra

DOI: 10.5958/0974-4150.2017.00130.4         Access: Open Access Read More

Molecular Docking – Useful Tool in Drug Discovery

Author(s): Anagha Bagal, Tai Borkar, Trupti Ghige, Anushka Kulkarni, Aakanksha Kumbhar, Ganesh Devane, Sachin Rohane

DOI: 10.52711/0974-4150.2022.00020         Access: Open Access Read More

Studies on Synthesis of Aromatic Schiff Bases. Part-VI. Synthesis, Characterization and Biological Activity of Ketimines from 5-Chloro-2-hydroxy-4-methyl-acetophenone with substituted anilines

Author(s): S. B. Salve, C. J. Patil, H. A. Mahajan

DOI: 10.5958/0974-4150.2018.00058.5         Access: Open Access Read More

Synthesis, Characterization and Biological Evaluation of Ciprofloxacin N-N Donor Metal Complex

Author(s): Prafulla M Sabale, Dhiraj S Bhagwat, Karan Parwe

DOI: 10.5958/0974-4150.2018.00105.0         Access: Open Access Read More

The Aminopyrimidines-I

Author(s): Parmesh Kumar Dwivedi, Kishu Tripathi, Mamta Mishra

DOI:         Access: Open Access Read More

Biological Activity of Some (2E)-Substituted-2-Ethylidene-5,6- Diphenylimidazo[2,1-b][1,3]Thiazol-3-(2H)-Ones

Author(s): Bhaskar VH, Kumar M, Balakrishnan BR, Sangameswaran B

DOI:         Access: Open Access Read More

Design, Synthesis and Characterisation of Novel Carbazole Linked Propeonones

Author(s): Kouser Unnisa, Tahseen Sameena, Habeeba Sulthana, Hafsa Siddiqua, Maimunna Khatoon

DOI: 10.5958/0974-4150.2017.00044.X         Access: Open Access Read More

Metallosulpha Drugs: Synthesis and Bioactivity

Author(s): Vikram Singh, N.K. Kaushik, Ram Singh

DOI:         Access: Open Access Read More

Imidazolidine Derivatives: A Comprehensive Review of their Biological Activities and Therapeutic Potential

Author(s): G. Muhubhupathi, M. Selvakumar, K. Mohanapriya, T. Brindha, B. Brindha Sri, Y. Mahalakshmi, P. Gayathri

DOI: 10.52711/0974-4150.2025.00008         Access: Closed Access Read More

A New Simple Method for Determination of Partition Coefficient by Normal Phase Thin Layer Chromatography (TLC).

Author(s): Akshada N. Kakade, Shrikant B. Deshmukh, Pankaj P. Chothe, Vishal V. Khot, Shrinivas K. Mohite, Chandrakant S. Magdum

DOI:         Access: Open Access Read More

Synthesis, Structure and Spectral Charectarization of Friedal Craft N-Benzylation of Isatin and Their Novel Schiff’s Bases

Author(s): RA Hajare, RM Gaurkhede, PP Chinchole, AV Chandewar, AS Wandhare, SS Karki

DOI:         Access: Open Access Read More

The Aminopyrimidines-II

Author(s): Parmesh Kumar Dwivedi, Kishu Tripathi, Mamta Mishra

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Quick Links

Latest Issues

Popular Articles


Recent Articles



Conductivity Evaluation of Smart Hydrogels composed of Polyacrylamide-Polyaniline
Analytical Method Development and Validation of Amlodipine Besylate by UV-Visible Spectroscopy
Estimation of Emtricitabine by Extractive Colorimetric Methods in Bulk and Pharmaceutical Dosage Form
Therapeutic Potential of Oxazolidine Derivative: A Critical Review of Their Biological Activities
Electrochemically grown Polymer-graphene Quantum dot composites for Oxygen Reduction Reaction
Determination of Drotaverine hydrochloride from Pharmaceutical Dosage form by extractive Ion pair complex Colorimetric Method
A Review on Inorganic materials with its Biomedical Applications
Pharmaceutical Insights and Therapeutic Importance of Pottali Kalpana – A Literature Review
A Simplified Approach to Evaluating Water Absorption Kinetics in Swellable Polymer Matrices
Validation of Emtricitabine by Application of Reactive Dyes in from Pharmaceutical Dosages
Synthesis, Complexation, Spectral and Antibacterial Activity of 2-[Z-(Hydroxyimino)Methyl]Phenol and Its Mn(II) Complex
Synthesis, Characterization, Spectroscopic Study of Schiff Base Ligand with some Transition Metal Complexes and Evaluation of Biological Activity
Synthesis, Spectral Characterization, Molecular Docking, DFT Studies and Biological Evaluation of N-(2-Oxo-2-(Phenylamino)Ethyl)Picolinamide Derivatives as Anti-Inflammatory and Antidiabetic Activity
Preparation of Proton Transfer Complex by N-Substituted Thio Barbituric Acid with Amine Bases
Artificial Intelligence in the Biomedical Field
Examining Resveratrol’s Health Benefits: The Potency of Wine
Imidazolidine Derivatives: A Comprehensive Review of their Biological Activities and Therapeutic Potential
Disaster Management, Water-Remediation and Application of Mzenes – A Visionary Future and the Vast Road Ahead
Aminothiophene and Schiff base derivative-synthesis, Density Functional theory, ADME study and it’s characterization
A Review of Imidazole Derivatives: Synthesis, Pharmacological Applications, and Future Perspectives

Tags


About Journal

Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
Read More  

Visitors

Today: 319
Yesterday: 3844
Total: 2093327